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Total 11221 results found since Jan 2013.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
This study elucidates systemic metabolic dyshomeostasis mechanisms that underlie human mitochondrial myopathies and identifies potential new targets for metabolic intervention.PMID:37222423 | DOI:10.15252/emmm.202216951
Source: Molecular Medicine - May 24, 2023 Category: Molecular Biology Authors: Nneka Southwell Guido Primiano Viraj Nadkarni Nabeel Attarwala Emelie Beattie Dawson Miller Sumaitaah Alam Irene Liparulo Yevgeniya I Shurubor Maria Lucia Valentino Valerio Carelli Serenella Servidei Steven S Gross Giovanni Manfredi Qiuying Chen Marilena Source Type: research
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease
Transl Res. 2023 May 21:S1931-5244(23)00088-9. doi: 10.1016/j.trsl.2023.05.002. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (H...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2023 Category: Laboratory Medicine Authors: Emma Fletcher Dimitrios Miserlis Kristina Sorokolet Dylan Wilburn Cassandra Bradley Evlampia Papoutsi Trevor Wilkinson Andrew Ring Lucas Ferrer Gleb Haynatzki Robert S Smith William T Bohannon Panagiotis Koutakis Source Type: research
Molecular therapies: present and future in neuromuscular diseases
CONCLUSION: Clinical research in the field of molecular therapy of neuromuscular diseases is one of the pacesetters of modern precision medicine; however, challenges need to be seen, jointly addressed and overcome in the future.PMID:37221259 | DOI:10.1007/s00115-023-01495-3
Source: Der Nervenarzt - May 23, 2023 Category: Neurology Authors: Andreas Ziegler Maggie C Walter Benedikt E Schoser Source Type: research
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease
Transl Res. 2023 May 21:S1931-5244(23)00088-9. doi: 10.1016/j.trsl.2023.05.002. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (H...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2023 Category: Laboratory Medicine Authors: Emma Fletcher Dimitrios Miserlis Kristina Sorokolet Dylan Wilburn Cassandra Bradley Evlampia Papoutsi Trevor Wilkinson Andrew Ring Lucas Ferrer Gleb Haynatzki Robert S Smith William T Bohannon Panagiotis Koutakis Source Type: research
Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy
J Autoimmun. 2023 May 21;138:103063. doi: 10.1016/j.jaut.2023.103063. Online ahead of print.ABSTRACTThe rarity and heterogeneity of idiopathic inflammatory myopathy (IIM) pose challenges for researching IIM in affected individuals. We analyzed integrated transcriptomic datasets obtained using muscle tissues from patients with five distinct IIM subtypes to investigate the shared and distinctive cellular and molecular characteristics. A transcriptomic dataset of muscle tissues from normal controls (n = 105) and patients with dermatomyositis (n = 89), polymyositis (n = 33), inclusion body myositis (n = 121), immune-mediated n...
Source: Journal of Autoimmunity - May 23, 2023 Category: Allergy & Immunology Authors: Su-Jin Moon Seung Min Jung In-Woon Baek Kyung-Su Park Ki-Jo Kim Source Type: research
Amyopathic dermatomyositis with TIF1? positivity treated with IVIG
We present a patient with anti-TIF1? positive amyopathic dermatomyositis associated with bilateral breast cancer. The patient was safely treated with trastuzumab for breast cancer and intravenous immunoglobulin for dermatomyositis.PMID:37220289 | DOI:10.5070/D329260773
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Simon W Jiang Jeffery T Kwock Anne L Marano Source Type: research
Paraneoplastic or treatment-associated dermatomyositis: a diagnostic challenge
Dermatol Online J. 2023 Apr 15;29(2). doi: 10.5070/D329260768.ABSTRACTDermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, l...
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Miguel Esperanca-Martins Sara Damaso Nuno Carreira Barbara Pena Catarina Correia Marta Aguado-Lobo Pablo Espinosa-Lara Luis Soares-de-Almeida Leonor Abreu Ribeiro Luis Costa Source Type: research
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease
Transl Res. 2023 May 21:S1931-5244(23)00088-9. doi: 10.1016/j.trsl.2023.05.002. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (H...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2023 Category: Laboratory Medicine Authors: Emma Fletcher Dimitrios Miserlis Kristina Sorokolet Dylan Wilburn Cassandra Bradley Evlampia Papoutsi Trevor Wilkinson Andrew Ring Lucas Ferrer Gleb Haynatzki Robert S Smith William T Bohannon Panagiotis Koutakis Source Type: research
Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy
J Autoimmun. 2023 May 21;138:103063. doi: 10.1016/j.jaut.2023.103063. Online ahead of print.ABSTRACTThe rarity and heterogeneity of idiopathic inflammatory myopathy (IIM) pose challenges for researching IIM in affected individuals. We analyzed integrated transcriptomic datasets obtained using muscle tissues from patients with five distinct IIM subtypes to investigate the shared and distinctive cellular and molecular characteristics. A transcriptomic dataset of muscle tissues from normal controls (n = 105) and patients with dermatomyositis (n = 89), polymyositis (n = 33), inclusion body myositis (n = 121), immune-mediated n...
Source: Journal of Autoimmunity - May 23, 2023 Category: Allergy & Immunology Authors: Su-Jin Moon Seung Min Jung In-Woon Baek Kyung-Su Park Ki-Jo Kim Source Type: research
Amyopathic dermatomyositis with TIF1? positivity treated with IVIG
We present a patient with anti-TIF1? positive amyopathic dermatomyositis associated with bilateral breast cancer. The patient was safely treated with trastuzumab for breast cancer and intravenous immunoglobulin for dermatomyositis.PMID:37220289 | DOI:10.5070/D329260773
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Simon W Jiang Jeffery T Kwock Anne L Marano Source Type: research
Paraneoplastic or treatment-associated dermatomyositis: a diagnostic challenge
Dermatol Online J. 2023 Apr 15;29(2). doi: 10.5070/D329260768.ABSTRACTDermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, l...
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Miguel Esperanca-Martins Sara Damaso Nuno Carreira Barbara Pena Catarina Correia Marta Aguado-Lobo Pablo Espinosa-Lara Luis Soares-de-Almeida Leonor Abreu Ribeiro Luis Costa Source Type: research
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease
Transl Res. 2023 May 21:S1931-5244(23)00088-9. doi: 10.1016/j.trsl.2023.05.002. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (H...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2023 Category: Laboratory Medicine Authors: Emma Fletcher Dimitrios Miserlis Kristina Sorokolet Dylan Wilburn Cassandra Bradley Evlampia Papoutsi Trevor Wilkinson Andrew Ring Lucas Ferrer Gleb Haynatzki Robert S Smith William T Bohannon Panagiotis Koutakis Source Type: research
Amyopathic dermatomyositis with TIF1? positivity treated with IVIG
We present a patient with anti-TIF1? positive amyopathic dermatomyositis associated with bilateral breast cancer. The patient was safely treated with trastuzumab for breast cancer and intravenous immunoglobulin for dermatomyositis.PMID:37220289 | DOI:10.5070/D329260773
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Simon W Jiang Jeffery T Kwock Anne L Marano Source Type: research
Paraneoplastic or treatment-associated dermatomyositis: a diagnostic challenge
Dermatol Online J. 2023 Apr 15;29(2). doi: 10.5070/D329260768.ABSTRACTDermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, l...
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Miguel Esperanca-Martins Sara Damaso Nuno Carreira Barbara Pena Catarina Correia Marta Aguado-Lobo Pablo Espinosa-Lara Luis Soares-de-Almeida Leonor Abreu Ribeiro Luis Costa Source Type: research
