This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 11221 results found since Jan 2013.

Gut microbiota dysbiosis characterized by abnormal elevation of Lactobacillus in patients with immune-mediated necrotizing myopathy
ConclusionWe observed a characteristic compositional change in the gut microbiota with an abnormal elevation of Lactobacillus in IMNM patients, which was accompanied by changes in clinical indicators. This suggests that gut microbiota dysbiosis occurs in IMNM patients and is correlated with systemic autoimmune features.
Source: Frontiers in cellular and infection microbiology - August 25, 2023 Category: Microbiology Source Type: research

Decrement Evoked Potential (DEEP) Mapping of the Atria: Unmasking Atrial Fibrillation Substrate
Atrial myopathy may underlie the progression of atrial fibrillation (AF) from a treatable disease to an irreversible condition with poor ablation outcomes. Electrophysiological methods to unmask areas prone to re-entry initiation could be key to defining latent atrial myopathy.
Source: Heart, Lung and Circulation - August 25, 2023 Category: Cardiology Authors: Oscar Salvador Monta ñés, John L. Fitzgerald, Nicholas Jackson, Shouvik Haldar, Haseeb Valli, Josh Cotton, Gwilym M. Morris, Sigfus Gizurarson, José Angel Cabrera, Kumaraswamy Nanthakumar, Andreu Porta-Sánchez Tags: Original Article Source Type: research

An early onset benign myopathy with glycogen storage caused by a de novo 1.4 Mb-deletion of chromosome 14
Early onset myopathies (EOM) are inherited monogenic muscle conditions with variable clinical expression. The onset of disease is during infancy or early childhood with hypotonia, muscle weakness, delayed motor development, and sometimes central nervous system involvement [1]. The two main groups of early onset myopathies are congenital muscular dystrophies (CMDs) and congenital myopathies (CMs) [2]. CMDs are genetically heterogeneous and characterized by severe weakness with elevated serum Creatine kinases, prominent contractures, and often central nervous system (CNS) involvement [3].
Source: Neuromuscular Disorders - August 25, 2023 Category: Neurology Authors: Gianmarco Severa, Alessandra Pennisi, Christine Barnerias, Chiara Fiorillo, Marcello Scala, Valentina Taglietti, Andreea Iuliana Cojocaru, Dima Jouni, Lucie Tosca, G érard Tachdjian, Isabelle Desguerre, François-Jérome Authier, Robert-Yves Carlier, Cor Tags: Case report Source Type: research

Precision therapy for a medically actionable ATP1A3 variant from a genomic medicine program in an underserved population
ConclusionIn retrospect, his symptomatology matches the known medical conditions associated with theATP1A3 gene namely Alternating Hemiplegia of Childhood 2 (AHC), a rare autosomal dominant disorder with an incidence of 1 in one million. His single nucleotide variant, (c.2401G>A, p.D801N), is predicted to be damaging. The specific amino acid change p.D801N has been previously reported in ClinVar along with the allelic variant p.D801Y and both are considered pathogenic. The identification of this variant altered medical management for this patient as he was started on a calcium antagonist and has reported no further hemi...
Source: Molecular Genetics & Genomic Medicine - August 24, 2023 Category: Genetics & Stem Cells Authors: Cara P. Ford, Rebecca O. Littlejohn, Ryan German, Blake Vuocolo, Jose Aceves, Liesbeth Vossaert, Nichole Owen, Michael Wangler, Carrie A. Schmid, The Texome Project Tags: CLINICAL REPORT Source Type: research

Selective Blockade of Interleukin-6 Trans-signaling
Atrial fibrillation (AF) has been accepted as an inflammatory atrial myopathy. Interleukin 6 (IL-6)-dependent inflammatory signaling pathways take context-dependent effects on cardiovascular diseases. The IL-6 trans-signaling is predominantly pro-inflammatory. However, its effect on AF is unclear.
Source: Heart Rhythm - August 24, 2023 Category: Cardiology Authors: Xintao Li, Xiaoyu Wu, Xiaoqiang Chen, Shi Peng, Songwen Chen, Genqing Zhou, Yong Wei, Xiaofeng Lu, Changzuan Zhou, Yutong Ye, Jun Li, Shaowen Liu, Juan Xu Source Type: research

Selective blockade of interleukin 6 trans-signaling depresses atrial fibrillation
Atrial fibrillation (AF) has been accepted as an inflammatory atrial myopathy. Interleukin 6 (IL-6) –dependent inflammatory signaling pathways take context-dependent effects on cardiovascular diseases. IL-6 trans-signaling is predominantly pro-inflammatory. However, its effect on AF is unclear.
Source: Heart Rhythm - August 24, 2023 Category: Cardiology Authors: Xintao Li, Xiaoyu Wu, Xiaoqiang Chen, Shi Peng, Songwen Chen, Genqing Zhou, Yong Wei, Xiaofeng Lu, Changzuan Zhou, Yutong Ye, Jun Li, Shaowen Liu, Juan Xu Source Type: research

A highly sensitive and quantitative assay for dystrophin protein using Single Molecule Count Technology
Duchenne muscular dystrophy (DMD) is a recessive X-linked myopathy caused by nonsense or frameshift mutations in the DMD gene, affecting 1 in 3,500 –6,000 newborn males [1]]. Dystrophin, encoded by the DMD gene, is expressed in skeletal muscle cells and cardiomyocytes. It forms complexes with glycoproteins that play an essential role in maintaining muscle cell membrane stability [2,3]. In patients with DMD, a lack of dystrophin causes cell me mbrane instability, resulting in severe muscle degeneration.
Source: Neuromuscular Disorders - August 22, 2023 Category: Neurology Authors: Misawa Niki Ishii, Maria Quinton, Hidenori Kamiguchi Source Type: research

Corrigendum: Characteristics of cardiac involvement in immune-mediated necrotizing myopathy
Source: Frontiers in Immunology - August 21, 2023 Category: Allergy & Immunology Source Type: research

Temporary hypothyroidism in severe crush syndrome: a potential novel entity
CONCLUSIONS: In severe forms of crush syndrome, temporary hypothyroidism might be seen. The exact mechanism underlying this entity is not well-known. Further clinical and experimental trials should be conducted to illuminate the mechanism of disrupted thyroid hormonogenesis in crush syndrome victims.PMID:37596376 | DOI:10.1007/s42000-023-00475-1
Source: Hormones - August 18, 2023 Category: Endocrinology Authors: Ahmet Burak Dirim Gamze Ergun Sezer Emine Uzun Murvet Yilmaz Source Type: research

Infraclavicular Catheter in MELAS Syndrome for Analgesic Purposes
M Onay, T Tanyel Kiremitçi, G Erdoğan Kayhan, D İlhan Algın, MS GüleçNeurology India 2023 71(4):764-766 MELAS syndrome is defined as mitochondrial myopathy accompanied by encephalopathy, lactic acidosis, myoclonus, stroke-like episodes. It has a progressive course, multi-systemic effects and severe complications. Myoclonic contractions are unresponsive to many anti-epileptic drugs; these contractions and spasms may lead to severe pain. Systemic analgesic drugs are not sufficient to control pain. Therefore, continuous brachial plexus blockage may be pr...
Source: Neurology India - August 18, 2023 Category: Neurology Authors: M Onay T Tanyel Kiremit & #231;i G Erdo & #287;an Kayhan D & #304;lhan Alg & #305;n MS G & #252;le & #231; Source Type: research

Pyomyositis Secondary to Localized Cellulitis in a Dermatomyositis Patient: A Case Report and Review of Infectious Complications in Dermatomyositis
Clin Cosmet Investig Dermatol. 2023 Aug 11;16:2201-2209. doi: 10.2147/CCID.S417772. eCollection 2023.ABSTRACTDermatomyositis (DM) is an autoimmune disorder characterized by proximal muscle weakness and distinct cutaneous features. Unfortunately, infection is a frequent and potentially life-threatening complication in patients with DM. Here, we present a case of pyomyositis in a patient with DM resulting from localized cellulitis. The patient also presented with subcutaneous calcification nodules and dermatomyositis-associated lipodermatosclerosis nodules. To our knowledge, there have been no reports of pyomyositis in patie...
Source: Clinical, Cosmetic and Investigational Dermatology - August 17, 2023 Category: Dermatology Authors: Xingwei Zhang Xiaoyan Lyu Source Type: research