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Cancer: Skin Cancer
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Total 37430 results found since Jan 2013.
Does genetic risk modify the effect of skin screening on melanoma detection rates?
CONCLUSIONS: Genetic risk predicts subsequent melanoma incidence, and is weakly associated with screening behaviour, but does not explain the higher rate of melanoma detection between screened and unscreened people.PMID:37681503 | DOI:10.1093/bjd/ljad333
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Nirmala Pandeya Jean Claude Dusingize Catherine M Olsen Stuart MacGregor Rachel E Neale Matthew H Law David C Whiteman Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells
J Cell Mol Med. 2023 Sep 7. doi: 10.1111/jcmm.17935. Online ahead of print.ABSTRACTMucosal melanoma (MM) is a very rare and aggressive type of cancer for which immunotherapy or targeted therapy such as BRAF/MEK inhibitors, used in cutaneous melanoma, usually fail. Due to our earlier experience showing the high effectiveness of epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET) inhibitors in reducing the activation of the MAPK and PI3K/AKT signalling pathways, we aim to test whether these drugs would also be effective for mucosal melanoma. Cells representing two commercially available mucosa...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Aleksandra Simiczyjew Justyna W ądzyńska Magdalena Kot Marcin Zi ętek Rafa ł Matkowski Mai P Hoang Piotr Donizy Dorota Nowak Source Type: research
Does genetic risk modify the effect of skin screening on melanoma detection rates?
CONCLUSIONS: Genetic risk predicts subsequent melanoma incidence, and is weakly associated with screening behaviour, but does not explain the higher rate of melanoma detection between screened and unscreened people.PMID:37681503 | DOI:10.1093/bjd/ljad333
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Nirmala Pandeya Jean Claude Dusingize Catherine M Olsen Stuart MacGregor Rachel E Neale Matthew H Law David C Whiteman Source Type: research
Importance of tumor volume, overall treatment time and fractionation sensitivity for p16-positive and p16-negative oropharyngeal tumors
CONCLUSION: Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. The estimated α/β-ratio for p16-positive oropharyngeal tumors aligns with previous HNSCC studies, whereas the impact of prolonged OTT was slightly less than previously reported. The differences in radiosensitivity depending on p16-status were quantified. The findings should be validated in independent cohorts.PMID:37682690 | DOI:10.1080/0284186X.2023.2251084
Source: Acta Oncologica - September 8, 2023 Category: Cancer & Oncology Authors: Gabriel Adrian Maria Gebre-Medhin Per Nilsson Source Type: research
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease
CONCLUSION: CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.PMID:37680128 | DOI:10.2174/1381612829666230901143203
Source: Current Pharmaceutical Design - September 8, 2023 Category: Drugs & Pharmacology Authors: Fengyu Zhang Meidi Zhang Xin Yuan Yulian Tao Ju Wang Source Type: research
Naphthoquinone derivatives targeting melanoma
Curr Top Med Chem. 2023 Sep 1. doi: 10.2174/1568026623666230901124059. Online ahead of print.ABSTRACTCancer is responsible for high mortality rates worldwide, representing a serious health problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited, with problems associated with toxicity, serious side effects, and mechanisms of resistance. The potential of natural products for the prevention and treatment of melanoma has been reported in different studies. Among these compounds, napht...
Source: Current Topics in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: J éssica Alves Nunes Adrielle Firmino da Silva Nunes Dimas Jos é da Paz Lima Edeildo Ferreira da Silva-J únior Source Type: research
Unilateral acute iris transillumination syndrome with glaucoma and iris pigment epithelium dispersion simulating iris melanoma
CONCLUSION AND IMPORTANCE: Unilateral acute iris transillumination syndrome with diffuse iris pigment epithelial loss can simulate iris melanoma. Prompt herpes viral studies may be informative.PMID:37680309 | PMC:PMC10481171 | DOI:10.1016/j.ajoc.2023.101912
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Orlando G Gonzalez Martinez Carol L Shields Jerry A Shields Patricia Ch évez-Barrios Debbie Rigney Walley Ralph C Eagle Tatyana Milman Source Type: research
Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells
J Cell Mol Med. 2023 Sep 7. doi: 10.1111/jcmm.17935. Online ahead of print.ABSTRACTMucosal melanoma (MM) is a very rare and aggressive type of cancer for which immunotherapy or targeted therapy such as BRAF/MEK inhibitors, used in cutaneous melanoma, usually fail. Due to our earlier experience showing the high effectiveness of epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET) inhibitors in reducing the activation of the MAPK and PI3K/AKT signalling pathways, we aim to test whether these drugs would also be effective for mucosal melanoma. Cells representing two commercially available mucosa...
Source: J Cell Mol Med - September 8, 2023 Category: Molecular Biology Authors: Aleksandra Simiczyjew Justyna W ądzyńska Magdalena Kot Marcin Zi ętek Rafa ł Matkowski Mai P Hoang Piotr Donizy Dorota Nowak Source Type: research
A Novel Saliva and Serum miRNA Panel as a potential useful index for Oral Cancer and the Association of miR-21 with smoking history: a pilot study
Cancer Prev Res (Phila). 2023 Sep 8. doi: 10.1158/1940-6207.CAPR-23-0219. Online ahead of print.ABSTRACTTobacco use is implicated in the carcinogenesis of oral squamous cell carcinoma (OSCC), which is associated with poor survival if not diagnosed early. Identification of novel non-invasive, highly sensitive, and cost-effective diagnostic and risk assessment methods for OSCC would improve early detection. Here, we report a pilot study assessing salivary and serum miRNAs associated with OSCC and stratified by smoking status. Saliva and paired serum samples were collected from 23 OSCC patients and 21 healthy volunteers, with...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Dimitra P Vageli Panagiotis G Doukas Rema Shah Trinithas Boyi Christina Liu Benjamin L Judson Source Type: research
Unilateral acute iris transillumination syndrome with glaucoma and iris pigment epithelium dispersion simulating iris melanoma
CONCLUSION AND IMPORTANCE: Unilateral acute iris transillumination syndrome with diffuse iris pigment epithelial loss can simulate iris melanoma. Prompt herpes viral studies may be informative.PMID:37680309 | PMC:PMC10481171 | DOI:10.1016/j.ajoc.2023.101912
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Orlando G Gonzalez Martinez Carol L Shields Jerry A Shields Patricia Ch évez-Barrios Debbie Rigney Walley Ralph C Eagle Tatyana Milman Source Type: research
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease
CONCLUSION: CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.PMID:37680128 | DOI:10.2174/1381612829666230901143203
Source: Current Pharmaceutical Design - September 8, 2023 Category: Drugs & Pharmacology Authors: Fengyu Zhang Meidi Zhang Xin Yuan Yulian Tao Ju Wang Source Type: research
Does genetic risk modify the effect of skin screening on melanoma detection rates?
CONCLUSIONS: Genetic risk predicts subsequent melanoma incidence, and is weakly associated with screening behaviour, but does not explain the higher rate of melanoma detection between screened and unscreened people.PMID:37681503 | DOI:10.1093/bjd/ljad333
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Nirmala Pandeya Jean Claude Dusingize Catherine M Olsen Stuart MacGregor Rachel E Neale Matthew H Law David C Whiteman Source Type: research
Naphthoquinone derivatives targeting melanoma
Curr Top Med Chem. 2023 Sep 1. doi: 10.2174/1568026623666230901124059. Online ahead of print.ABSTRACTCancer is responsible for high mortality rates worldwide, representing a serious health problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited, with problems associated with toxicity, serious side effects, and mechanisms of resistance. The potential of natural products for the prevention and treatment of melanoma has been reported in different studies. Among these compounds, napht...
Source: Current Topics in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: J éssica Alves Nunes Adrielle Firmino da Silva Nunes Dimas Jos é da Paz Lima Edeildo Ferreira da Silva-J únior Source Type: research
Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease
CONCLUSION: CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.PMID:37680128 | DOI:10.2174/1381612829666230901143203
Source: Current Pharmaceutical Design - September 8, 2023 Category: Drugs & Pharmacology Authors: Fengyu Zhang Meidi Zhang Xin Yuan Yulian Tao Ju Wang Source Type: research
