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Total 6534 results found since Jan 2013.
Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-and-diabetic adults
Am J Physiol Endocrinol Metab. 2023 Aug 16. doi: 10.1152/ajpendo.00118.2023. Online ahead of print.ABSTRACTThe potential interaction between metformin and exercise on glucose-lowering effects remains controversial. We studied the separated and combined effects of metformin and/or exercise on fasting and postprandial insulin sensitivity in individuals with pre- and - type 2 diabetes (T2D). Eight T2D adults (60±4 years) with overweight/obesity (32±4 kg·m-2) under chronic metformin treatment (9±6 years; 1281±524 mg·day-1) underwent four trials; a) taking their habitual metformin treatment (MET), b) substituting during 9...
Source: American Journal of Physiology. Endocrinology and Metabolism - August 16, 2023 Category: Physiology Authors: Alfonso Moreno-Caba ñas Felix Morales-Palomo Laura Álvarez-Jimenez Diego Mora-Gonzalez Juan Fernando Ortega Ricardo Mora-Rodriguez Source Type: research
Tracking contaminants of concern in wet-weather sanitary sewer overflows
The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none...
Source: Environmental Science and Pollution Research International - August 15, 2023 Category: Environmental Health Authors: Colin H Besley Graeme E Batley Michele Cassidy Source Type: research
Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome
CONCLUSION: The findings imply that SAGEAE could be used as a new pharmaceutical formula in the treatment of obesity.PMID:37581324 | DOI:10.2174/1389201024666230811104740
Source: Current Pharmaceutical Biotechnology - August 15, 2023 Category: Biotechnology Authors: Diana A ALsherif Mohammed A Hussein Suzan S Abuelkasem Soha A Hassan Michael Wink Source Type: research
Tracking contaminants of concern in wet-weather sanitary sewer overflows
The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none...
Source: Environmental Science and Pollution Research International - August 15, 2023 Category: Environmental Health Authors: Colin H Besley Graeme E Batley Michele Cassidy Source Type: research
HDL abnormalities in type 2 diabetes: Clinical implications
Atherosclerosis. 2023 Aug 3:117213. doi: 10.1016/j.atherosclerosis.2023.117213. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) represents the primary cause of mortality among patients with Type 2 Diabetes Mellitus (T2DM). In this population, High-Density Lipoprotein (HDL) particles exhibit abnormalities in number, composition, and function, culminating in diminished anti-atherosclerotic capabilities despite normal HDL cholesterol (HDL-C) concentrations. Hyperglycemic conditions contribute to these alterations in HDL kinetics, composition, and function, causing T2DM patients' HDL particles to e...
Source: Atherosclerosis - August 14, 2023 Category: Cardiology Authors: Alexandro J Martagon Rafael Zubir án Rogelio Gonz ález-Arellanes Samantha Praget-Bracamontes J Adri án Rivera-Alcántara Carlos A Aguilar-Salinas Source Type: research
Mortality-related risk factors of inpatients with diabetes and COVID-19: a multicenter retrospective study in Belgium
CONCLUSION: In-hospital mortality due to the first wave of the COVID-19 pandemic in Belgium was high in patients with diabetes. We found that advanced age and male gender were independent risk factors for in-hospital death. We also showed that metformin use before admission was associated with significantly lower COVID-19-related in-hospital mortality. Finally, we showed that CKD is a COVID-19-related mortality risk factor in patients with diabetes admitted to the ICU.PMID:37574109 | DOI:10.1016/j.ando.2023.08.002
Source: Annales d'Endocrinologie - August 13, 2023 Category: Endocrinology Authors: Thomas Servais France Laurent Thomas Roland Camelia Rossi Elodie De Groote Val érie Godart Ernestina Repetto Michel Ponchon Pascale Chasseur Laurent Crenier Sandrine Van Eeckhoudt John Yango Philippe Oriot Mirela Morisca Gavriliu St éphanie Rouhard Benj Source Type: research
Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats
CONCLUSIONS: The novel injectable construct with hPDLSC and Met encapsulation demonstrated excellent efficacy for bone regeneration and vascularization in vivo in an animal model. CPC+hPDLSCs+ 0.1%Met is highly promising for dental and craniofacial applications.PMID:37574338 | DOI:10.1016/j.dental.2023.07.008
Source: Cancer Control - August 13, 2023 Category: Cancer & Oncology Authors: Yaxi Sun Zeqing Zhao Qingchen Qiao Shengnan Li Wenting Yu Xiuchen Guan Abraham Schneider Michael D Weir Hockin H K Xu Ke Zhang Yuxing Bai Source Type: research
Mortality-related risk factors of inpatients with diabetes and COVID-19: a multicenter retrospective study in Belgium
CONCLUSION: In-hospital mortality due to the first wave of the COVID-19 pandemic in Belgium was high in patients with diabetes. We found that advanced age and male gender were independent risk factors for in-hospital death. We also showed that metformin use before admission was associated with significantly lower COVID-19-related in-hospital mortality. Finally, we showed that CKD is a COVID-19-related mortality risk factor in patients with diabetes admitted to the ICU.PMID:37574109 | DOI:10.1016/j.ando.2023.08.002
Source: Annales d'Endocrinologie - August 13, 2023 Category: Endocrinology Authors: Thomas Servais France Laurent Thomas Roland Camelia Rossi Elodie De Groote Val érie Godart Ernestina Repetto Michel Ponchon Pascale Chasseur Laurent Crenier Sandrine Van Eeckhoudt John Yango Philippe Oriot Mirela Morisca Gavriliu St éphanie Rouhard Benj Source Type: research
Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage
In conclusion, our findings suggest that metformin might be a viable strategy for treating AR-related depression, possibly by modulating neuroplasticity, neurogenesis, apoptosis, and BDNF signaling in the OB via the AMPK/TET2 pathway.PMID:37574530 | DOI:10.1007/s11064-023-04012-9
Source: Neurochemical Research - August 13, 2023 Category: Neuroscience Authors: Hao Lv Ziang Gao Yunfei Wang Siyuan Chen Peiqiang Liu Yulie Xie Mengting Guan Jianchao Cong Yu Xu Source Type: research
Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review
Transl Res. 2023 Aug 9:S1931-5244(23)00130-5. doi: 10.1016/j.trsl.2023.08.001. Online ahead of print.ABSTRACTMetformin, a first-line management for Type 2 Diabetes Mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycaemic control. Beyond its established role, this therapeutic drug demonstrates a broad spectrum of action encompassing over sixty disorders, encompassing metabolic conditions, inflammatory disorders, carcinomas, cardiovascular diseases, and cerebrovascular pathologies. There is clear evidence of metformin's action targeting specific nodes in...
Source: Translational Research : the journal of laboratory and clinical medicine - August 11, 2023 Category: Laboratory Medicine Authors: Yifei Geng Zhen Wang Xiaoyu Xu Xiao Sun Xi Dong Yun Luo Xiaobo Sun Source Type: research
