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Total 6534 results found since Jan 2013.
The great obstetrical syndromes and the placenta
BJOG. 2023 Aug 2. doi: 10.1111/1471-0528.17613. Online ahead of print.ABSTRACTAlthough historically pre-eclampsia, preterm birth, abruption, fetal growth restriction and stillbirth have been viewed as clinically distinct entities, a growing body of literature has demonstrated that the placenta and its development is the root cause of many cases of these conditions. This has led to the term 'the great obstetrical syndromes' being coined to reflect this common origin. Although these conditions mostly manifest in the second half of pregnancy, a failure to complete deep placentation (the transition from histiotrophic placentat...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 2, 2023 Category: OBGYN Authors: Matthew K Hoffman Source Type: research
Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes
Reprod Biol Endocrinol. 2023 Aug 1;21(1):70. doi: 10.1186/s12958-023-01120-7.ABSTRACTPolycystic ovarian syndrome (PCOS) is a widespread syndrome that poses unique challenges and constraints to the field of assisted reproductive technology. This condition is the most common cause of anovulation among infertile couples. Debate exists over the best therapeutic course of action when patients with PCOS proceed to IVF. In this review, we evaluate the best-performing and safest methods of IVF preparation, ovarian stimulation, trigger method for maturation of stimulated egg growth, and planning for embryo transfer. Pre-IVF conside...
Source: Reproductive Biology - August 1, 2023 Category: Reproduction Medicine Authors: Alexander M Kotlyar David B Seifer Source Type: research
Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy
Nat Commun. 2023 Aug 1;14(1):4622. doi: 10.1038/s41467-023-40216-x.ABSTRACTCaspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe-/- mice as well as hematopoietic deletion in Ldlr-/- mice increases atherosclerosis. The acceleration of atherosclerosis is also observed in Apoe-/-Rag2-/-Card9-/- mice, ruling out a role for the adaptive immune system in the vascular phenotype of Card9 deficient mice. Card9 deficiency alters macrophage phenotype through CD36 overexpression with increased IL-1β...
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Yujiao Zhang Marie Vandestienne Jean-R émi Lavillegrand Jeremie Joffre Icia Santos-Zas Aonghus Lavelle Xiaodan Zhong Wilfried Le Goff Maryse Gu érin Rida Al-Rifai Ludivine Laurans Patrick Bruneval Coralie Gu érin Marc Diedisheim Melanie Migaud Anne Pue Source Type: research
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
CONCLUSIONS: Metformin attenuates CLAD in rat models, which could be attributed to the antifibrotic and immunomodulatory effects. AMPK activation suggests the potential molecular mechanism. Our study provides an experimental rationale for further clinical trials.PMID:37516880 | DOI:10.1186/s12931-023-02492-5
Source: Respiratory Care - July 29, 2023 Category: Respiratory Medicine Authors: Dong Tian Xiangyun Zheng Hongtao Tang Heng Huang Junjie Wang Lin Xu Caihan Li Haoji Yan Ruixuan Yu Jinzhu Nan Menggen Liu Xiaoguang Guo Shunhai Jian Tao Wang Senyi Deng Qiang Pu Lunxu Liu Source Type: research
Complex Case of Skull Base Osteomyelitis Secondary to Chronic Otitis Media
We present a case of a 58-year-old male with type II diabetes managed with metformin and insulin, who presented to the clinic with left chronic otitis media, persistent drainage, a stenotic meatus, and a prior history of 3 canal wall-down mastoidectomies and antibiotic therapy. A revision tympanoplasty with mastoidectomy was performed, and during the postoperative period, the patient had persistent pain and otorrhea, which were managed with opioids and several courses of antibiotic therapy. After symptoms persisted, imaging and culture ultimately led to the diagnosis of fungal skull base osteomyelitis, which was eventually...
Source: Ear, Nose and Throat Journal - July 29, 2023 Category: ENT & OMF Authors: Masa Petrovic Hannah G Landsberger Kevin A Peng Source Type: research
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
CONCLUSIONS: Metformin attenuates CLAD in rat models, which could be attributed to the antifibrotic and immunomodulatory effects. AMPK activation suggests the potential molecular mechanism. Our study provides an experimental rationale for further clinical trials.PMID:37516880 | DOI:10.1186/s12931-023-02492-5
Source: Cell Research - July 29, 2023 Category: Cytology Authors: Dong Tian Xiangyun Zheng Hongtao Tang Heng Huang Junjie Wang Lin Xu Caihan Li Haoji Yan Ruixuan Yu Jinzhu Nan Menggen Liu Xiaoguang Guo Shunhai Jian Tao Wang Senyi Deng Qiang Pu Lunxu Liu Source Type: research
Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression
AbstractThe high incidence rate coupled with significant mortality makes colorectal cancer one of the most prevalent and devastating cancers worldwide. Research is currently underway to explore new forms of treatment that could potentially maximize treatment outcomes while minimizing the side effects associated with conventional chemotherapy. Metformin, a natural biguanide drug, has anti-cancer properties that can inhibit the growth and proliferation of cancer cells. However, due to its short half-life and low bioavailability, the efficacy of Metf as an anti-cancer agent is limited. The purpose of this research is to asses...
Source: Medical Oncology - July 29, 2023 Category: Cancer & Oncology Source Type: research
Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice
This study investigated the pharmacological and pathological effects of aqueous mulberry leaf extract on type 1 diabetes mellitus mice induced with an intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomized into six groups: control (normal group), model, metformin-treated mice, and high-dose, medium-dose, and low-dose mulberry. The mulberry-treated mice were divided into high-, medium-, and low-dose groups based on the various doses of aqueous mulberry leaf extract during gavage. The efficacy of the six-week intervention was evaluated by measuring levels of fasting plasma glucose, alkaline phosphat...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Liru Luo Wei Fan Jingping Qin Shiyin Guo Hang Xiao Zhonghai Tang Source Type: research
