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Total 6534 results found since Jan 2013.
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Eur J Pharmacol. 2023 Aug 22:175991. doi: 10.1016/j.ejphar.2023.175991. Online ahead of print.ABSTRACTThe use of repurposing drugs that may have neoplastic and anticancer effects increases the efficiency and decrease resistance to chemotherapy drugs through a biochemical and mechanical transduction mechanisms through modulation of fibroblast/fibrosis remodeling in tumor microenvironment (TME). Interestingly, fibroblast/fibrosis remodeling plays a vital role in mediating cancer metastasis and drug resistance after immune chemotherapy. The most essential hypothesis for induction of chemo-immunotherapy resistance is via activ...
Source: European Journal of Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Mahboubeh Tajaldini Amirhoushang Poorkhani Taghi Amiriani Amirhossein Amiriani Hossein Javid Parham Aref Farahnazsadat Ahmadi Somayeh Sadani Vahid Khori Source Type: research
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia
EMBO Mol Med. 2023 Aug 23:e16908. doi: 10.15252/emmm.202216908. Online ahead of print.ABSTRACTPeriventricular neuronal heterotopia (PH) is one of the most common forms of cortical malformation in the human cortex. We show that human neuronal progenitor cells (hNPCs) derived from PH patients with a DCHS1 or FAT4 mutation as well as isogenic lines had altered migratory dynamics when grafted in the mouse brain. The affected migration was linked to altered autophagy as observed in vivo with an electron microscopic analysis of grafted hNPCs, a Western blot analysis of cortical organoids, and time-lapse imaging of hNPCs in the p...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Cedric Bressan Marta Snapyan Marina Snapyan Johannes Klaus Francesco di Matteo Stephen P Robertson Barbara Treutlein Martin Parent Silvia Cappello Armen Saghatelyan Source Type: research
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
J Mol Med (Berl). 2023 Aug 22. doi: 10.1007/s00109-023-02360-1. Online ahead of print.ABSTRACTTissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to adapt to the changes in the microenvironment and thus maintain tissue homeostasis. Several stresses, also those associated with the aging process, convert quiescent fibroblasts into myofibroblasts which not only display fibrogenic properties but also act as immune regulators cooperating both with tissue-resident immune cells and those immune cells r...
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Antero Salminen Source Type: research
Adding empagliflozin to sitagliptin plus metformin vs. adding sitagliptin to empagliflozin plus metformin as triple therapy in Egyptian patients with type 2 diabetes: a 12-week open trial
CONCLUSIONS: Empagliflozin was superior to sitagliptin in relation to glycemic control, weight, and systolic/diastolic blood pressure reduction.PMID:37606137 | DOI:10.26355/eurrev_202308_33300
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: H G Zakaraia H F Salem M A A Mostafa A M Ali H Rabea Source Type: research
Metformin, cognitive function, and changes in the gut microbiome
Endocr Rev. 2023 Aug 21:bnad029. doi: 10.1210/endrev/bnad029. Online ahead of print.ABSTRACTThe decline in cognitive function and the prevalence of neurodegenerative disorders are among the most serious threats to health in old age. The prevalence of dementia has reached 50 million people worldwide and has become one of the major public health problems. The causes of age-related cognitive impairment are multiple, complex, and difficult to determine. However, type 2 diabetes (T2D) is linked to an enhanced risk of cognitive impairment and dementia. Human studies have shown that patients with T2D exhibit dysbiosis of the gut ...
Source: ENDOCR REV - August 21, 2023 Category: Endocrinology Authors: Marisel Rosell-D íaz Jos é Manuel Fernández-Real Source Type: research
NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis
In conclusion, NDUFA4 promotes the progression of HNPGL, and NDUFA4 knockdown enhances Metformin-mediated inhibition of the HNPGL progression in a mouse model.PMID:37602474 | DOI:10.1139/bcb-2023-0018
Source: Biochemistry and Cell Biology - August 21, 2023 Category: Biochemistry Authors: Zhigang Wang Erxing Tao Yiming Chen Qi Wang Min Liu Liang Wei Siyi Xu Wei Chen Chunlong Zhong Source Type: research
Metformin, cognitive function, and changes in the gut microbiome
Endocr Rev. 2023 Aug 21:bnad029. doi: 10.1210/endrev/bnad029. Online ahead of print.ABSTRACTThe decline in cognitive function and the prevalence of neurodegenerative disorders are among the most serious threats to health in old age. The prevalence of dementia has reached 50 million people worldwide and has become one of the major public health problems. The causes of age-related cognitive impairment are multiple, complex, and difficult to determine. However, type 2 diabetes (T2D) is linked to an enhanced risk of cognitive impairment and dementia. Human studies have shown that patients with T2D exhibit dysbiosis of the gut ...
Source: ENDOCR REV - August 21, 2023 Category: Endocrinology Authors: Marisel Rosell-D íaz Jos é Manuel Fernández-Real Source Type: research
NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis
In conclusion, NDUFA4 promotes the progression of HNPGL, and NDUFA4 knockdown enhances Metformin-mediated inhibition of the HNPGL progression in a mouse model.PMID:37602474 | DOI:10.1139/bcb-2023-0018
Source: Biochemistry and Cell Biology - August 21, 2023 Category: Biochemistry Authors: Zhigang Wang Erxing Tao Yiming Chen Qi Wang Min Liu Liang Wei Siyi Xu Wei Chen Chunlong Zhong Source Type: research
