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Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice
Appl Biochem Biotechnol. 2023 Sep 4. doi: 10.1007/s12010-023-04675-8. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR include rhinorrhea, sneezing, itchy nose, congestion, teary eyes, and nasal rubbings. The present study assessed the beneficial properties of bakuchiol on OVA-induced AR in mice via the regulation of inflammatory responses. AR was induced by injecting (i.p.) OVA (50 µg) and aluminum hydroxide (1 mg) into mice at various time intervals. The bakuchiol treatment was done at dosag...
Source: Applied Biochemistry and Biotechnology - September 4, 2023 Category: Biochemistry Authors: Han Bing Yao Hesham S Almoallim Sulaiman Ali Alharbi Hui Feng Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice
Appl Biochem Biotechnol. 2023 Sep 4. doi: 10.1007/s12010-023-04675-8. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR include rhinorrhea, sneezing, itchy nose, congestion, teary eyes, and nasal rubbings. The present study assessed the beneficial properties of bakuchiol on OVA-induced AR in mice via the regulation of inflammatory responses. AR was induced by injecting (i.p.) OVA (50 µg) and aluminum hydroxide (1 mg) into mice at various time intervals. The bakuchiol treatment was done at dosag...
Source: Applied Biochemistry and Biotechnology - September 4, 2023 Category: Biochemistry Authors: Han Bing Yao Hesham S Almoallim Sulaiman Ali Alharbi Hui Feng Source Type: research
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice
Hear Res. 2023 Aug 29;438:108880. doi: 10.1016/j.heares.2023.108880. Online ahead of print.ABSTRACTTranstympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study ...
Source: Hearing Research - September 4, 2023 Category: Audiology Authors: Manon Jaffredo Oc éane Duchamp Nicolas Touya Yohan Bouleau Didier Dulon Raphael Devillard Damien Bonnard Source Type: research
PEG hydrogel containing dexamethasone-conjugated hyaluronic acid reduces secondary injury and improves motor function in a rat moderate TBI model
In this study, we evaluated the effect of locally applied PEG-bis-AA/HA-DXM hydrogel on secondary injury and motor function recovery after moderate controlled cortical impact (CCI) TBI. Hydrogel treatment significantly improved motor function evaluated by beam walk and rotarod tests compared to untreated rats over 7 days post-injury (DPI). We also observed that the hydrogel treatment reduced lesion volume, inflammatory response, astrogliosis, apoptosis, and increased neuronal survival compared to untreated rats at 7 DPI. These results suggest that PEG-bis-AA/HA-DXM hydrogels can mitigate secondary injury and promote motor ...
Source: Experimental Neurology - September 4, 2023 Category: Neurology Authors: Claire Jones Bradley Elliott Zhen Liao Zack Johnson Fuying Ma Zachary S Bailey Janice Gilsdorf Anke Scultetus Deborah Shear Ken Webb Jeoung Soo Lee Source Type: research
Connexin 43 gap junction affects survival and drug resistance of multiple myeloma side population cells
J Physiol Pharmacol. 2023 Jun;74(3). doi: 10.26402/jpp.2023.3.10. Epub 2023 Aug 30.ABSTRACTDrug resistance remains a major challenge for multiple myeloma (MM) treatment, and side population (SP) cells may play a key role in this resistance. The function of connexin 43 (Cx43)-mediated gap junction intercellular communication (GJ-IC) in MM cells is poorly understood. Bone marrow mesenchymal stem cells (BMSCs) from different sources were isolated and cultured. SP cells of MM cell line RPMI 8266 were separated by flow cytometry. Real-time reverse transcriptase-polymerase chain reaction and Western blot were used to detect Cx43...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: Z Wang J X Fu X H Zhang Y Sun X P Ge Source Type: research
