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A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR < sup > + < /sup > cells during antibody-mediated immune responses
Eur J Immunol. 2023 Aug 25:e2350454. doi: 10.1002/eji.202350454. Online ahead of print.ABSTRACTHuman immune system (HIS) mice provide a model to study human immune responses in vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR)-expressing cells that exert potent effector functions following administration of human Ig. Previous studies showed that the ablation of the murine FcR gamma chain (FcR-γ) results in loss of antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis in vivo. We created a new FcR-γ-deficient HIS mouse model to compare host (mouse) versus graft (...
Source: European Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Anna Louisa Thaller Friederike J önsson Oriane Fiquet Solenne Marie Jean-Marc Doisne Giulia Girelli-Zubani Toshiki Eri Priyanka Fernandes Evgeny Tatirovsky Francina Langa-Vives Pierre Bruhns H élène Strick-Marchand James P Di Santo Source Type: research
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses
This article is protected by copyright. All rights reserved.PMID:37621208 | DOI:10.1002/eji.202350454
Source: European Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Anna Louisa Thaller Friederike J önsson Oriane Fiquet Solenne Marie Jean-Marc Doisne Giulia Girelli-Zubani Toshiki Eri Priyanka Fernandes Evgeny Tatirovsky Francina Langa-Vives Pierre Bruhns H élène Strick-Marchand James P Di Santo Source Type: research
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR < sup > + < /sup > cells during antibody-mediated immune responses
Eur J Immunol. 2023 Aug 25:e2350454. doi: 10.1002/eji.202350454. Online ahead of print.ABSTRACTHuman immune system (HIS) mice provide a model to study human immune responses in vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR)-expressing cells that exert potent effector functions following administration of human Ig. Previous studies showed that the ablation of the murine FcR gamma chain (FcR-γ) results in loss of antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis in vivo. We created a new FcR-γ-deficient HIS mouse model to compare host (mouse) versus graft (...
Source: European Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Anna Louisa Thaller Friederike J önsson Oriane Fiquet Solenne Marie Jean-Marc Doisne Giulia Girelli-Zubani Toshiki Eri Priyanka Fernandes Evgeny Tatirovsky Francina Langa-Vives Pierre Bruhns H élène Strick-Marchand James P Di Santo Source Type: research
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses
This article is protected by copyright. All rights reserved.PMID:37621208 | DOI:10.1002/eji.202350454
Source: European Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Anna Louisa Thaller Friederike J önsson Oriane Fiquet Solenne Marie Jean-Marc Doisne Giulia Girelli-Zubani Toshiki Eri Priyanka Fernandes Evgeny Tatirovsky Francina Langa-Vives Pierre Bruhns H élène Strick-Marchand James P Di Santo Source Type: research
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR < sup > + < /sup > cells during antibody-mediated immune responses
Eur J Immunol. 2023 Aug 25:e2350454. doi: 10.1002/eji.202350454. Online ahead of print.ABSTRACTHuman immune system (HIS) mice provide a model to study human immune responses in vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR)-expressing cells that exert potent effector functions following administration of human Ig. Previous studies showed that the ablation of the murine FcR gamma chain (FcR-γ) results in loss of antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis in vivo. We created a new FcR-γ-deficient HIS mouse model to compare host (mouse) versus graft (...
Source: European Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Anna Louisa Thaller Friederike J önsson Oriane Fiquet Solenne Marie Jean-Marc Doisne Giulia Girelli-Zubani Toshiki Eri Priyanka Fernandes Evgeny Tatirovsky Francina Langa-Vives Pierre Bruhns H élène Strick-Marchand James P Di Santo Source Type: research
Adjusted indirect comparison of zanubrutinib and ibrutinib in first-line treatment of chronic lymphocytic leukemia
CONCLUSIONS: Assuming the uncertainty associated with the adjusted indirect comparison, zanubrutinib could be considered equivalent in efficacy to ibrutinib, however, the presence of differentiating safety features precludes assigning the two alternatives as equivalent therapeutic alternatives.PMID:37612185 | DOI:10.1016/j.farma.2023.07.006
Source: Farmacia Hospitalaria - August 23, 2023 Category: Drugs & Pharmacology Authors: Francisco Javier Salmer ón-Navas Ester Mar ía Barreiro-Fernández Silvia F énix-Caballero Source Type: research
