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Elevated periprostatic venous testosterone correlates with prostate cancer progression after radical prostatectomy
CONCLUSIONSThese data suggest that a large proportion of men have a previously unappreciated exposure to an undiluted and highly concentrated T supply. Elevated periprostatic T exposure was associated with worse clinical outcomes after radical prostatectomy.FUNDINGNational Cancer Institute (NCI), NIH grants R01CA172382, R01CA236780, R01CA261995, R01CA249279, and R50CA251961; US Army Medical Research and Development Command grants W81XWH2010137 and W81XWH-22-1-0082.PMID:37655657 | DOI:10.1172/JCI171117
Source: Clinical Prostate Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Mohammad Alyamani Patrick Michael Daniel Hettel Lewis Thomas Scott D Lundy Mike Berk Mona Patel Jianbo Li Hooman Rashidi Jesse K McKenney Eric A Klein Nima Sharifi Source Type: research
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research
Elevated periprostatic venous testosterone correlates with prostate cancer progression after radical prostatectomy
CONCLUSIONSThese data suggest that a large proportion of men have a previously unappreciated exposure to an undiluted and highly concentrated T supply. Elevated periprostatic T exposure was associated with worse clinical outcomes after radical prostatectomy.FUNDINGNational Cancer Institute (NCI), NIH grants R01CA172382, R01CA236780, R01CA261995, R01CA249279, and R50CA251961; US Army Medical Research and Development Command grants W81XWH2010137 and W81XWH-22-1-0082.PMID:37655657 | PMC:PMC10471166 | DOI:10.1172/JCI171117
Source: Clinical Prostate Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Mohammad Alyamani Patrick Michael Daniel Hettel Lewis Thomas Scott D Lundy Mike Berk Mona Patel Jianbo Li Hooman Rashidi Jesse K McKenney Eric A Klein Nima Sharifi Source Type: research
2023 Vascular Research Initiatives Conference: Structural and Immune Cells in Vascular Disease
JVS Vasc Sci. 2023 Jul 10;4:100117. doi: 10.1016/j.jvssci.2023.100117. eCollection 2023.ABSTRACTThe 2023 Vascular Research Initiatives Conference (VRIC) was held in Boston, Massachusetts, and coincided with the first day of Vascular Discovery 2023, hosted by the American Heart Association. VRIC attracts vascular clinicians, surgeon-scientists, and basic science researchers to a common arena to facilitate the exchange of basic and translational science to stimulate and inspire participants to study and find solutions to vascular conditions. The theme of the conference this year was "Structural and Immune Cells in Vascular D...
Source: Atherosclerosis - August 31, 2023 Category: Cardiology Authors: Carly Thaxton Katherine Gallagher Alan Dardik Source Type: research
Evaluating policy-driven capital for renewable energy investments in the presence of cross-sectional dependence: perspectives from financial institutions and markets
This study emphasizes the impact of financial institutions and markets on renewable energy investment using data from various regions (Asia, Africa, Europe, and America). The CS-ARDL model is employed for analysis during 1998-2021. The findings of the CS-ARDL highlight that financial institutions, financial markets, greenhouse gas emissions, and GDP help promote investments in renewable energy in the long run for all samples, including global, Asian, American, African, and European. However, the estimates of ICT and Trade have insignificant effects on investments in renewable energy. In the short run, most of the factors d...
Source: Environmental Science and Pollution Research International - August 31, 2023 Category: Environmental Health Authors: Muhammad Tayyab Sohail Source Type: research
Discussion Guide for the Laures Article
Am J Crit Care. 2023 Sep 1;32(5):355-356. doi: 10.4037/ajcc2023696.NO ABSTRACTPMID:37652878 | DOI:10.4037/ajcc2023696
Source: American Journal of Critical Care - August 31, 2023 Category: Nursing Authors: Grant A Pignatiello Source Type: research
A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells
Cell Death Discov. 2023 Aug 31;9(1):325. doi: 10.1038/s41420-023-01627-3.ABSTRACTCell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy Factor 1 (NAF-1; NAF-144-67), selectively permeates and kills human metastatic epithelial breast cancer cells (MDA-MB-231), but not control epithelial cells. As cancer cells alter their phenotype during growth and metastasis, we tested whether NAF-144-67 would also be efficient in killing other human epithelial breast cancer cells that m...
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Linda Rowland Henri-Baptiste Marjault Ola Karmi DeAna Grant Lauren J Webb Assaf Friedler Rachel Nechushtai Ron Elber Ron Mittler Source Type: research
Discussion Guide for the Laures Article
Am J Crit Care. 2023 Sep 1;32(5):355-356. doi: 10.4037/ajcc2023696.NO ABSTRACTPMID:37652878 | DOI:10.4037/ajcc2023696
Source: American Journal of Critical Care - August 31, 2023 Category: Nursing Authors: Grant A Pignatiello Source Type: research
