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Total 127493 results found since Jan 2013.
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-033123-123610. Online ahead of print.ABSTRACTRecent advances in chemical, molecular, and genetic approaches have provided us with an unprecedented capacity to identify drug-target interactions across the whole proteome and genome. Meanwhile, rapid developments of single-cell and spatial omics technologies are revolutionizing our understanding of the molecular architecture of biological systems. However, a significant gap remains in how we align our understanding of drug actions, traditionally based on molecular affinities, with the in vivo cellular and ...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Zhengyuan Pang Benjamin F Cravatt Li Ye Source Type: research
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
The heterogeneity of metabolic syndrome presentation and challenges this causes in its pharmacological management. A narrative review focusing on principal risk modifiers
Expert Rev Clin Pharmacol. 2023 Sep 18. doi: 10.1080/17512433.2023.2259306. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic syndrome (MetS), i.e. the cluster of cardiometabolic risk factors comprising visceral obesity, impaired glucose metabolism, arterial hypertension and atherogenic dyslipidemia, is prevalent globally and exacts a heavy toll on health care expenditures.AREAS COVERED: The pathophenotypes of individual traits of the MetS in adults are discussed first, with strong emphasis on nonalcoholic fatty liver disease (NAFLD) and sex differences. Next, I discuss recent studies on phenotypic and outcome heteroge...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Amedeo Lonardo Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-033123-123610. Online ahead of print.ABSTRACTRecent advances in chemical, molecular, and genetic approaches have provided us with an unprecedented capacity to identify drug-target interactions across the whole proteome and genome. Meanwhile, rapid developments of single-cell and spatial omics technologies are revolutionizing our understanding of the molecular architecture of biological systems. However, a significant gap remains in how we align our understanding of drug actions, traditionally based on molecular affinities, with the in vivo cellular and ...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Zhengyuan Pang Benjamin F Cravatt Li Ye Source Type: research
Role of organic cation transporter 3 (OCT3) in the response of hepatocellular carcinoma to tyrosine kinase inhibitors
In conclusion, analysis by immunohistochemistry of OCT3 in the PM of tumor cells may help to predict the response of HCC patients to sorafenib and potentially to other TKIs.PMID:37722628 | DOI:10.1016/j.bcp.2023.115812
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Elisa Herraez Ruba Al-Abdulla Meraris Soto Oscar Briz Dominik Bettinger Heike Bantel Sofia Del Carmen Maria A Serrano Andreas Geier Jose J G Marin Rocio I R Macias Source Type: research
Prostaglandin E < sub > 2 < /sub > and myocarditis; friend or foe?
Biochem Pharmacol. 2023 Sep 16:115813. doi: 10.1016/j.bcp.2023.115813. Online ahead of print.ABSTRACTThis review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) as it relates to the inflammatory cardiomyopathy, myocarditis. During the COVID-19 pandemic, the onset of myocarditis in a subset of patients prompted a debate on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, which act to inhibit the actions of prostaglandins. This review aims to further understanding of the role of PGE2 in the pathogenesis or protection of the myocardium in myocarditis. Inflammatory ca...
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Timothy D Bryson Pamela Harding Source Type: research
Differential contribution of 5-HT < sub > 4 < /sub > , 5-HT < sub > 5 < /sub > , and 5-HT < sub > 6 < /sub > receptors to acute pruriceptive processing induced by chloroquine and histamine in mice
Biol Pharm Bull. 2023 Sep 16. doi: 10.1248/bpb.b23-00445. Online ahead of print.ABSTRACTThe involvement of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing in the central nervous system (CNS) has been reported using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the roles of 5-HT receptor family in acute pruriceptive processing have not been fully elucidated in the CNS. In the present study, scratching behavior induced by chloroquine (CQ) was ameliorated by milnacipran or mirtaz...
Source: Biological and Pharmaceutical Bulletin - September 18, 2023 Category: Drugs & Pharmacology Authors: Yu Miyahara Hideki Funahashi Ayaka Haruta-Tsukamoto Yoichiro Kogoh Anna Kanemaru-Kawazoe Yoji Hirano Toshikazu Nishimori Yasushi Ishida Source Type: research
Prevalence of mutations associated with macrolide and fluoroquinolone resistance in Neisseria gonorrhoeae with Allplex NG-DR Assay (Seegene) in a tertiary hospital from Madrid, Spain
CONCLUSIONS: We report a low-prevalence of mutations A2059G/C2611T to macrolides and a high-prevalence to S91F in NG infections. Molecular methods for the detection of NG resistance could be useful in direct non-culturable samples.PMID:37721708 | DOI:10.37201/req/058.2023
Source: Revista Espanola de Quimioterapia - September 18, 2023 Category: Drugs & Pharmacology Authors: A Maldonado-Barrueco C Sanz-Gonz ález I Falces-Romero P Garc ía-Clemente J Cacho-Calvo I Quiles-Melero Source Type: research
Interventions to help patients withdraw from depression drugs: A systematic review
CONCLUSION: The true proportion of patients on depression drugs who can stop safely without relapse is likely considerably higher than the 50% we found.PMID:37718853 | DOI:10.3233/JRS-230011
Source: International Journal of Risk and Safety in Medicine - September 18, 2023 Category: Drugs & Pharmacology Authors: Peter C G øtzsche Maryanne Demasi Source Type: research
What is Polypharmacy in Patients with Chronic Kidney Disease? A Systematic Review
The objective of this review is to establish a unified definition of polypharmacy in the CKD population by examining the diverse definitions used in previously published studies.METHODS: A comprehensive search was conducted in relevant databases (PubMed, SCOPUS, Cochrane, and disease-specific databases) from 2000 to May 2022 to identify studies with polypharmacy threshold definitions in patients with CKD. Studies meeting the inclusion criteria were included in this review, and their methodologic quality was assessed.FINDINGS: Following the screening of the search results, duplicate records and studies that did not meet the...
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Azhar Al-Khulaifi Malkan Khatib Elrazi Ali Mohamed Yousif Ali Mohammed Ibn-Mas'ud Danjuma Source Type: research
Effectiveness and Safety of Eliglustat Treatment in Gaucher Disease: Real-Life Unicentric Experience
In this study, we evaluated the effectiveness and safety of eliglustat in a cohort of 12 patients with GD followed up in our center, reporting a reduction in both chitotriosidase (394.3 vs 181.1 nmol/h/mL, P = 0.027) and glucosylsphingosine values (45.1 vs 18.9 ng/mL, P <0.001) after at least 12 months of therapy compared with baseline, regardless of patient demographic characteristics and GD characteristics.FINDINGS: There were no drug-related serious adverse effects and no drug-related cardiac events. Most adverse events were mild and transient, mainly dyspepsia and abdominal pain. Of interest, we reported an absence ...
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Andrea Duminuco Manlio Fazio Stephanie Grasso Lara Gullo Carla Riccobene Valeria Calafiore Uros Markovic Francesco Di Raimondo Gaetano Giuffrida Source Type: research
Disulfiram-Like Reaction With Ginaton: A Case Report and Literature Review
This article details such a case from China. Healthcare providers should be proactive in educating patients about the potential adverse reactions related to using Ginaton and the importance of avoiding alcohol consumption while using it. Patients should also be advised to disclose their alcohol-consumption habits and seek medical advice before initiating treatment with any medication or supplement during treatment with Ginaton.PMID:37722955 | DOI:10.1016/j.clinthera.2023.08.013
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Xiangji Dang Rui Wang Yan Liu Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
