Filtered By:
Specialty: Drugs & Pharmacology
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 127493 results found since Jan 2013.
Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adenocarcinoma cells
In this study, we modified ExomiR-Tracker by incorporating branched nona-D-arginines (9 + 9 mer) molecules (referred to as Branch ExomiR-Tracker) and evaluated its efficacy in lung adenocarcinoma cells (A549 cells). The improved complex formation ability and enhanced cellular uptake of anti-miR, demonstrated by our findings, highlight the advantages of incorporating branched oligoarginine peptides into the ExomiR-Tracker platform. These results represent significant progress in revealing the effectiveness of Branch ExomiR-Tracker against adhesive cancer cells, which has not been shown to be effective with the conventional ...
Source: Chemical and Pharmaceutical Bulletin - September 20, 2023 Category: Drugs & Pharmacology Authors: Shota Oyama Mao Tomita Moeka Hata Yu Mikame Tsuyoshi Yamamoto Eishi Ashihara Asako Yamayoshi Source Type: research
Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells
In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.PMID:37729956 | DOI:10.1016/j.ejps.2023.106586
Source: European Journal of Pharmaceutical Sciences - September 20, 2023 Category: Drugs & Pharmacology Authors: Queenie Fernandes Lubna Therachiyil Abdul Q Khan Takwa Bedhiafi Hesham M Korashy Ajaz A Bhat Shahab Uddin Source Type: research
Clinical pharmacology of β-3 adrenergic receptor agonists for cardiovascular diseases
Expert Rev Clin Pharmacol. 2023 Sep 20:1-12. doi: 10.1080/17512433.2023.2193681. Online ahead of print.ABSTRACTINTRODUCTION: Few agonists of the third isotype of beta-adrenergic receptors, the β3-adrenoreceptor, are currently used clinically, and new agonists are under development for the treatment of overactive bladder disease. As the receptor is expressed in human cardiac and vascular tissues, it is important to understand their beneficial (or adverse) effect(s) on these targets.AREAS COVERED: We discuss the most recent results of clinical trials testing the benefit and safety of β3-adrenoreceptor activation on cardiov...
Source: Pharmacological Reviews - September 20, 2023 Category: Drugs & Pharmacology Authors: Jean-Luc Balligand Lauriane Y M Michel Source Type: research
Anti-prolactin treatment alleviates lupus conditions by regulating the JAK2-STAT3 pathway
CONCLUSIONS: In summary, these data suggest that PRL inhibition alleviates lupus-like disease in MRL/lpr mice by modulating the Jak2-Stat3 signalling cascade. More importantly, our results imply the potential of PRL inhibitors and may provide a novel therapeutic approach for lupus.PMID:37727880 | DOI:10.1111/1440-1681.13818
Source: Clinical and Experimental Pharmacology and Physiology - September 20, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Huyan Chen Jinran Lin Jiewen Pan Yanyun Shen Qiao Li Source Type: research
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. Therefore, we used semaglutide, a novel GLP-1R agonist currently undergoing two phase 3 clinical trials in AD patients, to observe the effect of SIRT1 after semaglutide treatment in 3XTg mice and HT22 cells, and to explore the mechanism of SIRT1 in the glucose metabolism disorders of AD. The mice were injected with semaglutide on alternate days for 30 days, followed by behavioral experiments including open field test, new object recognition test, and Y-maze. The content of glucose in the brain was also measured by usi...
Source: Neuropharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Zhao-Jun Wang Xin-Ru Li Shi-Fan Chai Wei-Ran Li Shuo Li Meng Hou Jia-Lei Li Yu-Cai Ye Hong-Yan Cai Christian H ölscher Mei-Na Wu Source Type: research
Personalized neoantigen cancer vaccines: An analysis of the clinical and commercial potential of ongoing development programs
Drug Discov Today. 2023 Sep 18:103773. doi: 10.1016/j.drudis.2023.103773. Online ahead of print.ABSTRACTNeoantigen cancer vaccines harbor promise as next-generation immuno-oncology therapies, whereby cancer vaccines are tailored to the patient's tumor antigen and represent the future of personalized cancer therapy. While several biotech companies have ongoing development programs, little has been published about the true commercial potential of these innovative therapies and the challenges these products will face upon regulatory approval. In this paper, we provide an overview of neoantigen cancer vaccine development progr...
Source: Drug Discovery Today - September 20, 2023 Category: Drugs & Pharmacology Authors: Maurice Perrinjaquet C Richard Schlegel Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Computational Studies and Synthesis of New Heterocyclics as CNS Agents
CONCLUSION: The designed scheme was executed in the departmental laboratory. The chemical structure of the compounds was confirmed on the basis of TLC, IR, and 1HNMR analyses. The docking study revealed a good docking score of the compounds. The Log P value of the compounds indicated their good penetration into CNS. The compounds were also screened for anxiolytic activity. Among them, compounds 4f, 4h, and P3 showed maximum activity as anti-anxiolytic agents.PMID:37723630 | DOI:10.2174/1570163820666230918100218
Source: Current Drug Discovery Technologies - September 19, 2023 Category: Drugs & Pharmacology Authors: Pooja Saini Sushil Kumar Source Type: research
Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases
Biomed Pharmacother. 2023 Sep 17;167:115512. doi: 10.1016/j.biopha.2023.115512. Online ahead of print.ABSTRACTSesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugate...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 19, 2023 Category: Drugs & Pharmacology Authors: Navneet Singh Sukriti Vishwas Amandeep Kaur Harmanpreet Kaur Violina Kakoty Rubiya Khursheed M V N L Chaitanya Molakpogu Ravindra Babu Ankit Awasthi Leander Corrie Vancha Harish Palakurthi Yanadaiah Saurabh Gupta Amany A Sayed Amr El-Sayed Iftikhar Ali Os Source Type: research
Interleukin-6 Inhibition and Lipoprotein(a): An Association Requiring More Research
Curr Pharm Des. 2023 Sep 18. doi: 10.2174/1381612829666230918112907. Online ahead of print.NO ABSTRACTPMID:37723629 | DOI:10.2174/1381612829666230918112907
Source: Current Pharmaceutical Design - September 19, 2023 Category: Drugs & Pharmacology Authors: Aris P Agouridis Theodosios D Filippatos Source Type: research
Antimicrobial bacterial metabolites: properties, applications and loading in liposomes for site-specific delivery
Curr Pharm Des. 2023 Sep 18. doi: 10.2174/1381612829666230918111014. Online ahead of print.ABSTRACTThe high levels of antibiotic resistance registered worldwide have become a serious health problem, threatening the currently available treatments for a serious of infection diseases. With antibiotics becoming less and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with even common infectious diseases, such as pneumonia. The inability to meet the ever-increasing demand to control microbial infection requires both the search for new antimicrobials and improved site-specif...
Source: Current Pharmaceutical Design - September 19, 2023 Category: Drugs & Pharmacology Authors: Camilla A S Valen ça Ana A T Barbosa Silvio S Dolabella Patricia Severino Carla Matos Karolline Krambeck Eliana B Souto Sona Jain Source Type: research
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP rev...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Eman Alaaeldin Hesham Refaat Entesar Ali Saber Neven Makram Aziz Nehad M Reda Abdel-Maqsoud Mohammed Mustafa Abd El Aleem Maha Yehia Kamel Fatma M Mady Source Type: research
Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer
In conclusion, utilizing CBP as a natural, time-dependent polymer in conjunction with Eudragit® S 100 to develop the flurbiprofen tablets seems like a promising approach for delivering drugs specifically to the colon.PMID:37726501 | DOI:10.1208/s12249-023-02646-0
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Sateesh Kumar Vemula Bhaskar Daravath Sridhar Babu Gummadi Michael Repka Source Type: research
New Insights into the Applications of 3D-Printed Biomaterial in Wound Healing and Prosthesis
The objective of this review is to emphasize interpretations from the pre-executed studies and to assess the worth of employing 3D-bioP in wound healing as well as prosthetics in terms of patient compliance, clinical outcomes, and economic viability. Furthermore, the benefits of applying 3D-bioP in wound healing over traditional methods have been covered along with the biocompatible biomaterials employed as bioinks has been discussion. Additionally, the review expands about the clinical trials in 3D-bioP field, showing promise of biomedical applicability of this technique with growing advancement in recent years.PMID:37726...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Aayushi Pandey None Pragya Jovita Kanoujia Poonam Parashar Source Type: research
Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity
AAPS PharmSciTech. 2023 Sep 19;24(7):192. doi: 10.1208/s12249-023-02648-y.ABSTRACTRheumatoid arthritis restricts the physical ability of patients and increases the disease burden; therefore, research has always been focused on evaluating better therapeutic options. The present research aimed to design Continentalic acid (CA)-loaded transfersomes (CA-TF) embedded in Carbopol gel containing permeation enhancer (PE) for the treatment of rheumatoid arthritis. CA-TF was developed via a modified thin film hydration method and incorporated into Carbopol 934 gel containing Eucalyptus oil (EO) as PE. The fabricated CA-TF showed par...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Muhammad Waseem Akram Danish Mazhar Iqra Afzal Ahmad Zeb Qurat Ul Ain Salman Khan Hussain Ali Source Type: research
