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Specialty: Cancer & Oncology
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Total 126553 results found since Jan 2013.
Comparison of the efficacy and safety of third-line treatments for metastatic colorectal cancer: a systematic review and network meta-analysis
ConclusionTAS-102, fruquintinib, TAS-102 plus bevacizumab, the regorafenib standard dose regimen (regorafenib), and the regorafenib dose-escalation regimen (regorafenib 80+) all demonstrated improved OS and PFS compared to BSC in mCRC patients. However, TAS-102 plus bevacizumab may be the optimal choice for third-line treatment in mCRC patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php, CRD42023434929.
Source: Frontiers in Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
Reirradiation versus systemic therapy versus combination therapy for recurrent high-grade glioma: a systematic review and meta-analysis of survival and toxicity
ConclusionsCombination therapy may improve OS and PFS with acceptable toxicities in patients with rHGG compared to reRT or systemic therapy alone. Particularly, combining bevacizumab with reRT prophylactically reduces radionecrosis.Registration: CRD42022291741.
Source: Journal of Neuro-Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
Early Mortality as a Quality Indicator in Frontline and Salvage Acute Myeloid Leukemia
CONCLUSIONS: Quality measure algorithms should incorporate a risk mortality index related to leukemia vs. other tumors and benign conditions and a risk mortality index related to the treatment status of leukemia (salvage vs. frontline therapy).PMID:37730483 | DOI:10.1016/j.clml.2023.08.016
Source: Clinical Lymphoma and Myeloma - September 20, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Farhad Ravandi Courtney DiNardo Mary Alma Welch Tapan Kadia Hagop Kantarjian Source Type: research
Early T-Cell Precursor Leukemia: A High-Risk Subtype of Acute Lymphoblastic Leukemia, Single Center Experience in Jordan
CONCLUSION: ETP-ALL/LBL represents a high-risk disease subtype of adult ALL. Novel treatment strategies are needed to improve treatment outcomes in this patient's population.PMID:37730482 | DOI:10.1016/j.clml.2023.08.007
Source: Clinical Lymphoma and Myeloma - September 20, 2023 Category: Cancer & Oncology Authors: Khalid Halahleh Isra Muradi Mohammad Zakaria Khalil Lina Halahleh Maher Sughayer Nazmi Kamal Iyad Sultan Kamal Alrabi Source Type: research
Effect of transversus abdominis plane block on postoperative outcomes in gynecologic oncology patients managed on an Enhanced Recovery After Surgery pathway
CONCLUSIONS: Surgeon-administered TAP blocks were associated with decreased length of stay and post-operative opioid use in patients not receiving scheduled NSAIDs. This decrease in opioid use was not associated with any increase in average or maximum pain scores.PMID:37729808 | DOI:10.1016/j.ygyno.2023.09.003
Source: Gynecologic Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Kristin A Black Gregg Nelson Natalie Goucher Joshua Foley Sophia Pin Michael Chong Sunita Ghosh Steven P Bisch Source Type: research
MicroRNA biomarkers and their use in evaluating the prognosis of lung cancer
CONCLUSION: The three miRNA composites identified, namely hsa-mir-21, hsa-mir-141, and hsa-mir-490, have the potential to serve as novel prognostic biomarkers and therapeutic targets for lung cancer.PMID:37728700 | DOI:10.1007/s00432-023-05404-8
Source: Clinical Lung Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Ruijie Wu Bohan Zhang Mengju He Yani Kang Gong Zhang Source Type: research
Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in DLBCL
CONCLUSIONS: TIL-B frequency is a significant prognostic factor in DLBCL and plays a crucial role in antitumor immune responses. This study provides novel insights into the prognostic determinants in DLBCL and TIL-B functions with important therapeutic implications.PMID:37728879 | DOI:10.1158/1078-0432.CCR-23-1554
Source: Clinical Cancer Research - September 20, 2023 Category: Cancer & Oncology Authors: Zijun Y Xu-Monette Yong Li Thomas Snyder Tiantian Yu Tingxun Lu Alexandar Tzankov Carlo Visco Govind Bhagat Wenbin Qian Karen Dybkaer April Chiu Wayne Tam Youli Zu Eric D Hsi Fredrick B Hagemeister Yingjun Wang Heounjeong Go Maurilio Ponzoni Andr és J M Source Type: research
Extraction of interoperable data from healthcare documents by identifying Common Data Elements: an analysis of Radiation Therapy Planning CT Physician Order Entry records
CONCLUSION: Structured and interoperable documentation of medical information can be achieved using common data elements. Our analysis showed that a lot of information recorded with healthcare documents can be presented with this approach. Yet, in the analyzed cohort of planning CT order entries, only a few common data elements were shared among the majority of documents. A common vocabulary and consensus upon relevant information is required to promote interoperability and standardization.PMID:37729894 | DOI:10.1159/000534204
Source: Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Fabio Dennst ädt Paul Martin Putora Michael Heuser Eugenia Vlaskou Badra Brigitta Gertrud Baumert Dominic Leiser Nikola Cihoric Source Type: research
Outcomes of patients with Child-Pugh B and unresectable hepatocellular carcinoma undergoing first-line systemic treatment with sorafenib, lenvatinib, or atezolizumab plus bevacizumab
CONCLUSION: Determining the hepatic reserve of patients with unresectable HCC might be useful for identifying patents suitable for systemic treatment for HCC. Atezo + Bev might prolong the PFS of patients with a Child-Pugh score of 7.PMID:37729889 | DOI:10.1159/000533859
Source: Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Chihiro Kikugawa Shinsuke Uchikawa Tomokazu Kawaoka Takahiro Kinami Shigeki Yano Kei Amioka Kensuke Naruto Yuwa Ando Kenji Yamaoka Masataka Tsuge Yumi Kosaka Kazuki Ohya Nami Mori Shintaro Takaki Keiji Tsuji Hirotaka Kouno Hiroshi Kohno Kei Morio Takashi Source Type: research
A CaCO < sub > 3 < /sub > -based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy
CONCLUSION: Accordingly, the potential of QD@Ca/ML-Arg-was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.PMID:37729741 | DOI:10.1016/j.tranon.2023.101771
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jiale Cai Guiping Hu Lihua Hu Junge Chen Dan Chen Dan Liu Xiaolei Wang Boxian Hu Cheng Li Source Type: research
Clinical characteristics and treatment efficacy of immune checkpoint inhibitors (ICIs) in patients with ICIs-induced Adrenal insufficiency
CONCLUSIONS: ICI-induced AI is a rare irAE, and close monitoring of cortisol levels is important. Patients diagnosed with AI after receiving immunotherapy seem to have a favorable outcome.PMID:37729740 | DOI:10.1016/j.tranon.2023.101787
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jing Xiang Xueni Liu Yue Hao Yanyan Zhu Minhua Wu Jian Lou Yonghui Wang Chunwei Xu Yanru Xie Jianhui Huang Source Type: research
Cancer Health Literacy in Black Women With Breast Cancer: A Comprehensive Literature Review
Clin J Oncol Nurs. 2023 Sep 15;27(5):507-513. doi: 10.1188/23.CJON.507-513.ABSTRACTBACKGROUND: Patients with cancer have unique health literacy needs that affect health outcomes. In regard to breast cancer, Black women are more commonly diagnosed with high-grade breast tumors and have increased mortality rates.OBJECTIVES: This review examines the role of health literacy and discusses health disparities that affect cancer health literacy and health behaviors in Black women with breast cancer.METHODS: A literature search was conducted using CINAHL®, PubMed®, Ovid®, and Google Scholar™. A total of 12 studies were identif...
Source: Clinical Breast Cancer - September 20, 2023 Category: Cancer & Oncology Authors: LaTarvia Moore Alexis Elizabeth Hayes Source Type: research
Identification of a novel five ferroptosis-related gene signature as a promising prognostic model for breast cancer
CONCLUSION: A novel five ferroptosis-related gene signature and nomogram could be used for prognostic prediction in BCa.PMID:37728703 | DOI:10.1007/s00432-023-05423-5
Source: Clinical Breast Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Tian- Cheng Cheng Jia-Hao Wu Bei Zhu Hai-Yan Gao Lin Zheng Wei-Xian Chen Source Type: research
Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report
CONCLUSION: To the best of our knowledge, this is the first case report of MMBC in the non-retroareolar region of the nipple without gynecomastia development. Mucinous tumors are easily missed during diagnosis, and the incidence of axillary lymph node metastases of chest mucinous tumors has increased.PMID:37727495 | PMC:PMC10506025 | DOI:10.12998/wjcc.v11.i25.5954
Source: Clinical Breast Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Qiang Sun Xu-Yan Liu Qi Zhang Hai Jiang Source Type: research
Practical Guidance on 177LuLu-PSMA-617 Treatment, Including Radiation Safety, Adverse Event Monitoring, and Patient Counseling
Clin J Oncol Nurs. 2023 Sep 15;27(5):539-547. doi: 10.1188/23.CJON.539-547.ABSTRACTBACKGROUND: The approval of the prostate-specific membrane antigen (PSMA)-targeted radio-ligand therapy [177Lu]Lu-PSMA-617 represents a shift toward precision medicine-based treatments for metastatic castration-resistant prostate cancer.OBJECTIVES: This review aims to provide practical advice and clinical considerations for working with [177Lu]Lu-PSMA-617; particularly, regarding the role of nurses in managing radiation safety, monitoring and reporting of adverse events, and counseling patients receiving this therapy.METHODS: Clinical data, ...
Source: Clinical Prostate Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Avery Spitz Rebecca Floyd Jennifer Sutton Linda Gardner Source Type: research
