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Specialty: Biochemistry
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Total 114746 results found since Jan 2013.
Recent studies on non-invasive biomarkers useful in biliary atresia - a literature review
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6858. Online ahead of print.ABSTRACTThe aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urina...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Anna Lew-Tusk Marta P ęksa Teresa Stachowicz-Stencel Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
Protective effect of paricalcitol in rat testicular damage induced by subchronic 1800 MHz radiofrequency radiation
Biochem Biophys Res Commun. 2023 Sep 12;680:42-50. doi: 10.1016/j.bbrc.2023.09.024. Online ahead of print.ABSTRACTIn the present study, the possible protective effects of paricalcitol (P) were investigated in testicular damage because of 1800 MHz radiofrequency radiation (RFR) exposure. Male Sprague Dawley rats 8-10 weeks old (n = 28) were randomly divided into four groups as control (C) (n = 7), RFR (n = 7, 1800 MHz RFR 1 h/day for 30 days), P (n = 7, 0.2 μg/kg paricalcitol, 3 times a week for 30 days), and RFR + P (n = 7, 1800 MHz RFR 1 h/day for 30 days +0.2 μg/kg paricalcitol, 3 times a week for 30 days). Testicular ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Burcu Demirba ğ Sava ş Aktaş Ülkü Çömelekoğlu İlker Kara Metin Yildirim Didem Derici Yildirim Source Type: research
Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 15:109746. doi: 10.1016/j.cbpc.2023.109746. Online ahead of print.ABSTRACTTris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic conc...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 17, 2023 Category: Biochemistry Authors: Hangke Peng Hongkai Wang Wen Li Chen Jing Weiwei Zhang Haocheng Zhao Fengxiao Hu Source Type: research
Angiogenesis inhibitor or aggressiveness marker? The function of endostatin in cancer through electrochemical biosensing
Bioelectrochemistry. 2023 Sep 14;155:108571. doi: 10.1016/j.bioelechem.2023.108571. Online ahead of print.ABSTRACTThis work reports the first electrochemical bioplatform developed for the determination of human endostatin (HE), a biomarker with recognized antiangiogenic potential whose elevated circulating levels have also been associated with the development of aggressive cancers. The developed electroanalytical biotool combines the benefits of using magnetic microparticles for the implementation of sandwich immunoassays and amperometric transduction on disposable carbon electrodes. A limit of detection (LOD) of 34.1 pg m...
Source: Bioelectrochemistry - September 17, 2023 Category: Biochemistry Authors: Sandra Tejerina-Miranda Mar ía Pedrero Marina Bl ázquez-García Ver ónica Serafín Ana Montero-Calle Maria Garranzo-Asensio A Julio Reviejo Jos é M Pingarrón Rodrigo Barderas Susana Campuzano Source Type: research
The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194985. doi: 10.1016/j.bbagrm.2023.194985. Online ahead of print.ABSTRACTThe human telomere contains multiple copies of the DNA sequence d(TTAGGG) which can fold into higher order intramolecular G-quadruplexes and regulate the maintenance of telomere length and chromosomal integrity. The nucleic acid binding protein heteronuclear ribonucleoprotein A1 (hnRNP A1) and its N-terminus proteolytic product UP1 have been shown to efficiently bind and unfold telomeric DNA G-quadruplex. However, the understanding of the molecular mechanism of the UP1 binding and unfolding telomeric G...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Xiaobin Ling Yuqi Yao Lei Ding Jin-Biao Ma Source Type: research
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
Post translational modifications at the verge of plant-geminivirus interaction
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194983. doi: 10.1016/j.bbagrm.2023.194983. Online ahead of print.ABSTRACTPlant-virus interaction is a complex phenomenon and involves the communication between plant and viral factors. Viruses have very limited coding ability yet, they are able to cause infection which results in huge agro-economic losses throughout the globe each year. Post-translational modifications (PTMs) are covalent modifications of proteins that have a drastic effect on their conformation, stability and function. Like the host proteins, geminiviral proteins are also subject to PTMs and these modifica...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Ashish Prasad Shambhavi Sharma Manoj Prasad Source Type: research
Tuning of the Chl < sub > D1 < /sub > and Chl < sub > D2 < /sub > properties in photosystem II by site-directed mutagenesis of neighbouring amino acids
Biochim Biophys Acta Bioenerg. 2023 Sep 15:149013. doi: 10.1016/j.bbabio.2023.149013. Online ahead of print.ABSTRACTPhotosystem II is the water/plastoquinone photo-oxidoreductase of photosynthesis. The photochemistry and catalysis occur in a quasi-symmetrical heterodimer, D1D2, that evolved from a homodimeric ancestor. Here, we studied site-directed mutants in PSII from the thermophilic cyanobacterium Thermosynechoccocus elongatus, focusing on the primary electron donor chlorophyll a in D1, ChlD1, and on its symmetrical counterpart in D2, ChlD2, which does not play a direct photochemical role. The main conserved amino acid...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Miwa Sugiura Masaya Kimura Naohiro Shimamoto Yuki Takegawa Makoto Nakamura Kazumi Koyama Julien Sell és Alain Boussac A William Rutherford Source Type: research
Glucose absorption activity and gene expression of sugar transporters in the trophotaenia of the viviparous teleost Xenotoca eiseni
Biochim Biophys Acta Gen Subj. 2023 Sep 15:130464. doi: 10.1016/j.bbagen.2023.130464. Online ahead of print.ABSTRACTIn viviparous reproductive systems, nutrient transfer from mother to embryo plays a critical role in the generation of offspring. Herein, we investigated the mother-to-embryo nutrient transfer machinery in the viviparous teleost Xenotoca eiseni, which belongs to the family Goodeidae. The intraovarian embryo absorbs maternal supplements via the hindgut-derived placental structure termed the trophotaenia. Tracer analysis indicated that the trophotaenia can take up glucose analogs in ex vivo cultured embryos. Th...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Atsuo Iida Natsuho Tsuda Junki Yoshida Jumpei Nomura Adisorn Ratanayotha Takafumi Kawai Eiichi Hondo Source Type: research
Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research
Extracellular vimentin as a versatile immune suppressive protein in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188985. doi: 10.1016/j.bbcan.2023.188985. Online ahead of print.ABSTRACTThe interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the tumor-associated blood vessels are a promising target. We recently found that the intermediate filament protein vimentin is externalized by endothelial cells of the tumor vasculature. Extracellular vimentin was shown to sustain angiogenesis by mimicking VEGF and supporting cell migration, as well as endothelial cell anergy, the unresponsiveness of the endothel...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Karlijn van Loon Mathilda E van Breest Smallenburg Elisabeth J M Huijbers Arjan W Griffioen Judy R van Beijnum Source Type: research
The dual role of citrate in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188987. doi: 10.1016/j.bbcan.2023.188987. Online ahead of print.ABSTRACTCitrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid synthesis, gluconeogenesis, insulin secretion, bone tissues formation, spermatozoid mobility, and immune response. Dysregulation of citrate metabolism is implicated in several pathologies, including cancer. Here we discuss how cancer cells use citrate to sustain their proliferation, survival, and metastatic progression. Also...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Philippe Icard Luca Simula Grit Zahn Marco Alifano Maria E Mycielska Source Type: research
Targeting STING in cancer: Challenges and emerging opportunities
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188983. doi: 10.1016/j.bbcan.2023.188983. Online ahead of print.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key pathway through which the host regulates immune responses by recognizing cytoplasmic double-stranded DNA of abnormal origin, and it plays an important role in tumor growth as well as metastasis, with relevant molecular details constantly being explored and updated. The significant immunomodulatory effects make STING an attractive target for cancer immunotherapy, and STING agonists have been receiving great at...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Kexin Zhao Jiaojiao Huang Yue Zhao Shengjun Wang Juan Xu Kai Yin Source Type: research
