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Therapy: Neoadjuvant Therapy

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Impacts of florfenicol on immunity, antioxidant activity, and histopathology of Oreochromis niloticus: a potential protective effect of dietary spirulina platensis
AbstractThe misuse of antibiotics enhances the development of resistant microorganisms and decreases the efficacy of treatments. Florfenicol (FF) is one of the antibiotics approved for use in aquaculture in Egypt. Because of its extensive usage, potential negative impacts on aquatic creatures are a major concern. This motivates us to search for an appropriate neoadjuvant to work synergistically with FF and reduce adverse effects. Results from this study will contribute towards improving the understanding of the impacts of FF onOreochromis niloticus and the possible amelioratory effects ofSpirulina platensis algae (SP).O. n...
Source: Veterinary Research Communications - August 11, 2023 Category: Veterinary Research Source Type: research

Pathologic complete response and survival in HER2-low and HER2-zero early breast cancer treated with neoadjuvant chemotherapy
CONCLUSIONS: In eBC patients treated with NAC, taking into account HR expression subtype and other current clinicopathological features, HER2-low tumors did not appear to have different chemosensitivity or prognosis, compared to their HER2-0 counterparts.PMID:37561255 | DOI:10.1007/s12282-023-01490-1
Source: Breast Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Silvia Mihaela Ilie Nathalie Briot Guillaume Constantin Nicolas Roussot Alis Ilie Anthony Bergeron Laurent Arnould Fran çoise Beltjens Isabelle Desmoulin Didier Mayeur Cour èche Kaderbhai Audrey Hennequin Cl émentine Jankowski Marie Martine Padeano Hel Source Type: research

ASO Author Reflections: Menopausal Status Does Not Predict Successful Breast Conservation Surgery After Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma
Ann Surg Oncol. 2023 Aug 10. doi: 10.1245/s10434-023-14131-w. Online ahead of print.NO ABSTRACTPMID:37561346 | DOI:10.1245/s10434-023-14131-w
Source: Ann Oncol - August 10, 2023 Category: Cancer & Oncology Authors: Kirithiga Ramalingam Rita Mukhtar Source Type: research

Successful Breast Conservation After Neoadjuvant Chemotherapy in Lobular Breast Cancer: The Role of Menopausal Status in Response to Treatment
CONCLUSION: NAC was not associated with successful BCS in either premenopausal or postmenopausal patients with ILC. Although premenopausal patients were more likely to receive NAC, these data suggest that menopausal status may not be a good predictor of response to chemotherapy. Better predictors of response and more efficacious treatment for patients with ILC are needed.PMID:37561345 | DOI:10.1245/s10434-023-14075-1
Source: Ann Oncol - August 10, 2023 Category: Cancer & Oncology Authors: Kirithiga Ramalingam Elle Clelland Harriet Rothschild Firdows Mujir Helena Record Mandeep Kaur Rita A Mukhtar Source Type: research

Pathologic complete response and survival in HER2-low and HER2-zero early breast cancer treated with neoadjuvant chemotherapy
CONCLUSIONS: In eBC patients treated with NAC, taking into account HR expression subtype and other current clinicopathological features, HER2-low tumors did not appear to have different chemosensitivity or prognosis, compared to their HER2-0 counterparts.PMID:37561255 | DOI:10.1007/s12282-023-01490-1
Source: Breast Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Silvia Mihaela Ilie Nathalie Briot Guillaume Constantin Nicolas Roussot Alis Ilie Anthony Bergeron Laurent Arnould Fran çoise Beltjens Isabelle Desmoulin Didier Mayeur Cour èche Kaderbhai Audrey Hennequin Cl émentine Jankowski Marie Martine Padeano Hel Source Type: research

Tumor-Infiltrating Lymphocytes in HER2-Low Breast Cancer
CONCLUSION: TILs in HER2-low are marginally higher than HER2-negative, but significantly lower than HER2-positive levels. HER2-low tumors do not seem to significantly differ biologically from HER2-negative tumors.PMID:37562994 | DOI:10.1016/j.clbc.2023.07.007
Source: Clinical Genitourinary Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Italo Fernandes Anderson Scorsato Rafael Kaliks Marcus Corpa Eduarda Damasceno Gustavo Schvartsman Source Type: research

CTLA-4 and its inhibitors in esophageal cancer: efficacy of therapy and potential mechanisms of adverse events
Am J Cancer Res. 2023 Jul 15;13(7):3140-3156. eCollection 2023.ABSTRACTEsophageal cancer is one of the most prevalent diseases in the world, and its prognosis remains poor. Surgery, chemotherapy, and radiotherapy are the most common treatment strategies for esophageal cancer. Although these conventional treatment methods are sometimes beneficial, patients with esophageal cancer still have a high risk of local relapse and metastasis. Thus, novel and effective therapies are needed. Immune checkpoint inhibitors are a type of immunotherapy being studied as a treatment for patients with advanced cancers, and strategies using su...
Source: Cell Research - August 10, 2023 Category: Cytology Authors: Chenrui Tian Xiaohui Wang Sheng Zhang Source Type: research

Clinical significance of regulatory T cells and T lymphocyte subsets in peripheral blood in neoadjuvant chemotherapy for breast cancer
Am J Cancer Res. 2023 Jul 15;13(7):3091-3099. eCollection 2023.ABSTRACTThe impact of the immune response on the therapeutical efficacy of neoadjuvant chemotherapy for breast cancer remains largely unknown. To characterize the role of regulatory T cells (CD4+CD25+CD127lowTreg), T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) and NK cells in neoadjuvant chemotherapy, we investigated the correlation patterns of these immune cell subsets with the progression of breast cancer. A total of 120 breast cancer patients receiving neoadjuvant chemotherapy in Nanjing Maternal and Child Health Hospital from May 2019 to November 2021 were r...
Source: Cell Research - August 10, 2023 Category: Cytology Authors: Xiao-Dong Mao Su-Zhu Chen Su-Qing Shen Kang-Sheng Liu Source Type: research

ASO Author Reflections: Menopausal Status Does Not Predict Successful Breast Conservation Surgery After Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma
Ann Surg Oncol. 2023 Aug 10. doi: 10.1245/s10434-023-14131-w. Online ahead of print.NO ABSTRACTPMID:37561346 | DOI:10.1245/s10434-023-14131-w
Source: Ann Oncol - August 10, 2023 Category: Cancer & Oncology Authors: Kirithiga Ramalingam Rita Mukhtar Source Type: research

Successful Breast Conservation After Neoadjuvant Chemotherapy in Lobular Breast Cancer: The Role of Menopausal Status in Response to Treatment
CONCLUSION: NAC was not associated with successful BCS in either premenopausal or postmenopausal patients with ILC. Although premenopausal patients were more likely to receive NAC, these data suggest that menopausal status may not be a good predictor of response to chemotherapy. Better predictors of response and more efficacious treatment for patients with ILC are needed.PMID:37561345 | DOI:10.1245/s10434-023-14075-1
Source: Ann Oncol - August 10, 2023 Category: Cancer & Oncology Authors: Kirithiga Ramalingam Elle Clelland Harriet Rothschild Firdows Mujir Helena Record Mandeep Kaur Rita A Mukhtar Source Type: research

Tumor-Infiltrating Lymphocytes in HER2-Low Breast Cancer
CONCLUSION: TILs in HER2-low are marginally higher than HER2-negative, but significantly lower than HER2-positive levels. HER2-low tumors do not seem to significantly differ biologically from HER2-negative tumors.PMID:37562994 | DOI:10.1016/j.clbc.2023.07.007
Source: Clinical Genitourinary Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Italo Fernandes Anderson Scorsato Rafael Kaliks Marcus Corpa Eduarda Damasceno Gustavo Schvartsman Source Type: research

Pathologic complete response and survival in HER2-low and HER2-zero early breast cancer treated with neoadjuvant chemotherapy
CONCLUSIONS: In eBC patients treated with NAC, taking into account HR expression subtype and other current clinicopathological features, HER2-low tumors did not appear to have different chemosensitivity or prognosis, compared to their HER2-0 counterparts.PMID:37561255 | DOI:10.1007/s12282-023-01490-1
Source: Breast Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Silvia Mihaela Ilie Nathalie Briot Guillaume Constantin Nicolas Roussot Alis Ilie Anthony Bergeron Laurent Arnould Fran çoise Beltjens Isabelle Desmoulin Didier Mayeur Cour èche Kaderbhai Audrey Hennequin Cl émentine Jankowski Marie Martine Padeano Hel Source Type: research