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Therapy: Neoadjuvant Therapy
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Total 9996 results found since Jan 2013.
Systemic treatments for resectable carcinoma of the esophagus
World J Gastroenterol. 2023 Aug 14;29(30):4628-4641. doi: 10.3748/wjg.v29.i30.4628.ABSTRACTOne of the most prevalent malignancies in the world is esophageal cancer (EC). The 5-year survival rate of EC remains pitiful despite treatment advancements. Neoadjuvant chemoradiotherapy in conjunction with esophagectomy is the standard of care for patients with resectable disease. The pathological complete response rate, however, is not acceptable. A distant metastasis or a locoregional recurrence will occur in about half of the patients. To increase the clinical effectiveness of therapy, it is consequently vital to investigate cut...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
Correction: Timing is Everything: Neoadjuvant Versus Adjuvant Immunotherapy in Patients with Resectable Metastatic Melanoma
Ann Surg Oncol. 2023 Sep 3. doi: 10.1245/s10434-023-14252-2. Online ahead of print.NO ABSTRACTPMID:37661225 | DOI:10.1245/s10434-023-14252-2
Source: Ann Oncol - September 3, 2023 Category: Cancer & Oncology Authors: Ashley M Holder Jennifer A Wargo Merrick I Ross Source Type: research
The assessment of pathological response to neoadjuvant chemotherapy in muscle-invasive bladder cancer patients with DCE-MRI and DWI: a systematic review and meta-analysis
CONCLUSION: This meta-analysis demonstrated high diagnostic performance of both DCE-MRI and DWI in predicting the pathological response to NAC in MIBC. DWI might be a potential substitute for DCE-MRI, with no significant difference in diagnostic performance between the two. However, caution should be taken when applying our results, as our results were based on indirect comparison.ADVANCES IN KNOWLEDGE: No previous studies have comprehensively analysed the value of DCE-MRI and DWI in evaluating the pathological response to NAC in MIBC. According to the current study, both DCE-MRI and DWI yielded high diagnostic performance...
Source: The British Journal of Radiology - September 3, 2023 Category: Radiology Authors: Ruilong Zong Xijuan Ma Yibing Shi Li Geng Source Type: research
Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit
CONCLUSION: NAR score may be repurposed to generate a prognostic tool in gastric adenocarcinoma to predict 5-year OS and has the potential to guide decision-making regarding allocation of adjuvant therapy. Further studies should prospectively validate these findings to confirm clinical utility.PMID:37659978 | DOI:10.1245/s10434-023-14259-9
Source: Ann Oncol - September 2, 2023 Category: Cancer & Oncology Authors: Chase J Wehrle Caleb N Seavey Jenny Chang Katherine Stackhouse Kimberly Woo Toms Augustin Daniel Joyce Robert Simon R Matthew Walsh Samer A Naffouje Source Type: research
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
CONCLUSION: Although a diet and exercise intervention did not affect RDI, the intervention was associated with a higher pCR in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative and triple-negative breast cancer undergoing neoadjuvant chemotherapy.PMID:37656930 | DOI:10.1200/JCO.23.00871
Source: Clinical Genitourinary Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Tara Sanft Maura Harrigan Courtney McGowan Brenda Cartmel Michelle Zupa Fang-Yong Li Leah M Ferrucci Leah Puklin Anlan Cao Thai Hien Nguyen Marian L Neuhouser Dawn L Hershman Karen Basen-Engquist Beth A Jones Tish Knobf Anees B Chagpar Andrea Silber Anna Source Type: research
Economic burden of early-stage non-small-cell lung cancer: an assessment of healthcare resource utilization and medical costs
Conclusion: Post-surgical management of early-stage NSCLC was associated with high economic burden. Adjuvant therapy was associated with numerically lower medical costs over surgical resection alone.PMID:37655686 | DOI:10.57264/cer-2023-0107
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Jon Apple Maral DerSarkissian Anne Shah Rose Chang Yan Chen Xuanhao He Justin Chun Source Type: research
Brief Report: Acetaminophen Reduces Neoadjuvant Chemoimmunotherapy Efficacy in Patients With NSCLC by Promoting Neutrophil Extracellular Trap Formation: Analysis From a Phase 2 Clinical Trial
CONCLUSIONS: APAP could impair neoadjuvant chemoimmunotherapy efficacy in patients with NSCLC by promoting neutrophil activation and neutrophil extracellular trap formation.PMID:37654895 | PMC:PMC10466912 | DOI:10.1016/j.jtocrr.2023.100556
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Chongwu Li Junqi Wu Lei Zhang Fang Wang Long Xu Yue Zhao Yun Xiao Fenghui Zhuang Likun Hou Deping Zhao Yunlang She Dong Xie Chang Chen Source Type: research
The Predictive Utility of MammaPrint and BluePrint in Identifying Patients with Locally Advanced Breast Cancer Who are Most Likely to Have Nodal Downstaging and a Pathologic Complete Response After Neoadjuvant Chemotherapy
CONCLUSIONS: Patients with genomically High Risk tumors, defined by MammaPrint with or without BluePrint, respond better to NCT and have a higher likelihood of nodal downstaging compared with patients with gLuminal A tumors. These genomic signatures can be used to select node-positive patients who are more likely to have nodal downstaging and avoid invasive surgical procedures.PMID:37658272 | DOI:10.1245/s10434-023-14027-9
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: Peter Blumencranz Mehran Habibi Steve Shivers Geza Acs Lisa E Blumencranz Erin B Yoder Bastiaan van der Baan Andrea R Menicucci Patricia Dauer William Audeh Charles E Cox Source Type: research
Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre randomised controlled NeoRes II trial
CONCLUSION: Prolonged time to surgery did not improve histological complete response or other pathological endpoints, while there was a strong trend towards worse survival, suggesting caution in routinely delaying surgery for more than six weeks after nCRT.PMID:37657554 | DOI:10.1016/j.annonc.2023.08.010
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: K Nilsson F Klevebro B Sunde I Rouvelas M Lindblad E Szabo I Halldestam U Smedh B Wallner J Johansson G Johnsen E K Aahlin H-O Johannessen G Alexandersson von D öbeln G O Hjortland N Wang Y Shang D Borg A Quaas I Bartella C Bruns W Schr öder M Nilsson Source Type: research
Brief Report: Acetaminophen Reduces Neoadjuvant Chemoimmunotherapy Efficacy in Patients With NSCLC by Promoting Neutrophil Extracellular Trap Formation: Analysis From a Phase 2 Clinical Trial
CONCLUSIONS: APAP could impair neoadjuvant chemoimmunotherapy efficacy in patients with NSCLC by promoting neutrophil activation and neutrophil extracellular trap formation.PMID:37654895 | PMC:PMC10466912 | DOI:10.1016/j.jtocrr.2023.100556
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Chongwu Li Junqi Wu Lei Zhang Fang Wang Long Xu Yue Zhao Yun Xiao Fenghui Zhuang Likun Hou Deping Zhao Yunlang She Dong Xie Chang Chen Source Type: research
Pelvic insufficiency fractures and pelvic bone metastases after neoadjuvant (chemo)radiotherapy for rectal cancer
Conclusion: PIFs are a relatively common late complication of neoadjuvant (C)RT for rectal cancer but are often missed or misdiagnosed as pelvic bone metastases. The differentiation of PIFs from pelvic bone metastases is important because of a different treatment and disease outcome.PMID:37656773 | DOI:10.1080/0284186X.2023.2252168
Source: Acta Oncologica - September 1, 2023 Category: Cancer & Oncology Authors: Lotte Rijpma-Jacobs Ellen van der Vlies David B Meek Thomas L Bollen Peter D Siersema Bas L A M Weusten Martijn Intven Niels van Lelyveld Maartje Los Source Type: research
Brief Report: Acetaminophen Reduces Neoadjuvant Chemoimmunotherapy Efficacy in Patients With NSCLC by Promoting Neutrophil Extracellular Trap Formation: Analysis From a Phase 2 Clinical Trial
CONCLUSIONS: APAP could impair neoadjuvant chemoimmunotherapy efficacy in patients with NSCLC by promoting neutrophil activation and neutrophil extracellular trap formation.PMID:37654895 | PMC:PMC10466912 | DOI:10.1016/j.jtocrr.2023.100556
Source: Clinical Lung Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Chongwu Li Junqi Wu Lei Zhang Fang Wang Long Xu Yue Zhao Yun Xiao Fenghui Zhuang Likun Hou Deping Zhao Yunlang She Dong Xie Chang Chen Source Type: research
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
CONCLUSION: Although a diet and exercise intervention did not affect RDI, the intervention was associated with a higher pCR in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative and triple-negative breast cancer undergoing neoadjuvant chemotherapy.PMID:37656930 | DOI:10.1200/JCO.23.00871
Source: Clinical Breast Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Tara Sanft Maura Harrigan Courtney McGowan Brenda Cartmel Michelle Zupa Fang-Yong Li Leah M Ferrucci Leah Puklin Anlan Cao Thai Hien Nguyen Marian L Neuhouser Dawn L Hershman Karen Basen-Engquist Beth A Jones Tish Knobf Anees B Chagpar Andrea Silber Anna Source Type: research
