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Therapy: Radiation Therapy
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Total 11968 results found since Jan 2013.
Primary tumor site for localized Merkel cell carcinoma drives different management strategies without impacting oncologic outcomes
CONCLUSIONS: Among patients with primary MCC who had RT as a component of their initial treatment strategy, anatomically-driven heterogeneous treatment approaches were associated with equally excellent locoregional disease control.PMID:37659660 | DOI:10.1016/j.radonc.2023.109892
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 2, 2023 Category: Radiology Authors: Samuel Cass Brandon Cope Andrew J Bishop Yi-Ju Chiang B Ashleigh Guadagnolo Ahsan Farooqi William Morrison Russell G Witt Riyad N H Seervai Adam S Garden Clifton D Fuller Ryan P Goepfert Merrick Ross Jeffrey E Gershenwald Michael Wong Phyu P Aung Emily Z Source Type: research
Need for standardization in the use of structures in the intensity-modulated radiation therapy planning of head and neck cancers, a GORTEC study
Conclusion Use of nsRS is frequent but heterogeneous and should be standardized further in line with ICRU initiatives in IMRT planning. Use of nsRS should be documented with respect to the need for nsRS from dose computation algorithms of treatment planning systems and IMRT machines in terms of modulation capacity and plan robustness.PMID:37659657 | DOI:10.1016/j.radonc.2023.109895
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 2, 2023 Category: Radiology Authors: Özgür Özer Hanaan Shafi David O'Reilly Cedric Loiseau Catherine Dejean Jean Bourhis Juliette Thariat Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
The role of thoracic consolidative radiotherapy in the setting of immunotherapy in extensive stage small cell lung cancer
Ther Adv Med Oncol. 2023 Aug 24;15:17588359231192399. doi: 10.1177/17588359231192399. eCollection 2023.ABSTRACTThe improvement in treatment strategies and outcomes in small cell lung cancer (SCLC) has lagged behind other cancers. The addition of immune checkpoint inhibitors (ICIs), durvalumab and atezolizumab, to the platinum-based chemotherapy in frontline setting has improved the survival in extensive stage SCLC, (ES-SCLC), albeit modestly, and is now the new standard of care. Prior to advent of immunotherapy into the therapeutic armamentarium in ES-SCLC, consolidative thoracic radiotherapy (TRT) was associated with impr...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Saurav Verma Sympascho Young Alexander V Louie David Palma Daniel Breadner Source Type: research
The role of radiation therapy in the management of primary retroperitoneal sarcoma: A systematic review and clinical practice guidelines from the Australia and New Zealand Sarcoma Association
Cancer Treat Rev. 2023 Aug 28;120:102620. doi: 10.1016/j.ctrv.2023.102620. Online ahead of print.ABSTRACTWhile surgery is the mainstay of treatment for localised retroperitoneal sarcoma, the use of radiotherapy (RT) remains controversial. This systematic review aimed to evaluate the role of RT for retroperitoneal sarcoma. A systematic review using the population, intervention, comparison, and outcome model from 1990 to 2022 identified 66 studies (a mixture of preoperative and postoperative RT); one randomised controlled trial (RCT) with two publications, 18 registry studies, and 46 retrospective studies. In the RCT of preo...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Anna Lawless Deborah Di-Xin Zhou Joshua McDonough Helen Lo Jasmine Mar Smaro Lazarakis Iain Ward Joanna Connor Stephen R Thompson David Coker Andrew Johnston David E Gyorki Angela M Hong Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Clinical Lung Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Comprehensive Analysis of Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy
CONCLUSIONS: This is the first prospective evidence that limiting dose scatter by PBT significantly reduced the incidence of G4L, especially in the intermediate-risk patients. The implication of this immune sparing effect of PBT, especially in the context of standard adjuvant immunotherapy, needs further examination in the current phase 3 randomized trials.PMID:37652304 | DOI:10.1016/j.ijrobp.2023.08.058
Source: Health Physics - August 31, 2023 Category: Physics Authors: Xin Wang Peter S N van Rossum Yan Chu Brian P Hobbs Clemens Grassberger Theodore S Hong Zhongxing Liao Jinzhong Yang Xiaodong Zhang Tucker Netherton Radhe Mohan Steven H Lin Source Type: research
Study on the transferability of the knowledge-based VMAT model to predict IMRT plans in prostate cancer radiotherapy
CONCLUSION: Compared with the manual plan, the IMRT plans generated by the KBP models had a significant advantage in dose control of both OARs and PTV. Compared to the I-IMRT plans, the V-IMRT plans was not only without significant disadvantages, but it also achieved slightly better control of the low-dose region, which meet the clinical requirements and can used in the clinical treatment. This study demonstrates that it is feasible to transfer the KBP VMAT model in the prediction of IMRT plans.PMID:37653551 | DOI:10.1186/s40001-023-01278-1
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Suyan Bi Xingru Sun Wan Fatihah Binti Wan Sohaimi Ahmad Lutfi Bin Yusoff Source Type: research
Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Comprehensive Analysis of Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy
CONCLUSIONS: This is the first prospective evidence that limiting dose scatter by PBT significantly reduced the incidence of G4L, especially in the intermediate-risk patients. The implication of this immune sparing effect of PBT, especially in the context of standard adjuvant immunotherapy, needs further examination in the current phase 3 randomized trials.PMID:37652304 | DOI:10.1016/j.ijrobp.2023.08.058
Source: Health Physics - August 31, 2023 Category: Physics Authors: Xin Wang Peter S N van Rossum Yan Chu Brian P Hobbs Clemens Grassberger Theodore S Hong Zhongxing Liao Jinzhong Yang Xiaodong Zhang Tucker Netherton Radhe Mohan Steven H Lin Source Type: research
Developing a Prediction Model for Radiation Pneumonitis in Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy Combined With Clinical, Dosimetric Factors, and Laboratory Biomarkers
CONCLUSION: Age, lung volume, fractional dose, V10, and Hb levels were demonstrated to be significant factors associated with grade ≥2 RP for lung cancer patients after SBRT. A novel model combining clinical, dosimetric factors, and laboratory biomarkers improved predictive performance compared with the clinical and dosimetric model alone.PMID:37648569 | DOI:10.1016/j.cllc.2023.08.007
Source: Clinical Lung Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Bao-Tian Huang Pei-Xian Lin Ying Wang Li-Mei Luo Source Type: research
Radiation therapy in the thoracic region: Radio-induced cardiovascular disease, cardiac delineation and sparing, cardiac dose constraints, and cardiac implantable electronic devices
This article will summarize available cardiac dose constraints in various clinical settings and the types of radio-induced cardiovascular diseases encountered as well as delineation of cardiac subheadings and management of cardiac devices. Although still not completely deciphered, heart dose constraints remain intensively investigated and the mean dose to the heart is no longer the only dosimetric parameter to consider since the left anterior descending artery as well as the left ventricle should also be part of dosimetry constraints.PMID:37648559 | DOI:10.1016/j.canrad.2023.06.027
Source: Cancer Radiotherapie - August 30, 2023 Category: Cancer & Oncology Authors: C Petit A Escande T Sarrade L Vaugier Y Kirova A Tallet Source Type: research
Definitive ablative stereotactic partial breast irradiation in early stage inoperable breast cancer
CONCLUSIONS: Our case series suggests that definitive ablative radiation therapy may serve as a safe and effective treatment option for non-operable patients with early stage breast cancer. The observed durable treatment responses and minimal toxicity support the potential of this approach. Furthermore, a longer interval between ablative radiation therapy and surgery may enhance treatment response, potentially leading to increased complete pathologic response rates.PMID:37648809 | DOI:10.1007/s00432-023-05053-x
Source: Clinical Genitourinary Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Mihailo Miljanic Chika Nwachukwu Assal Rahimi Source Type: research
Selecting the optimal radiation modality in prostate cancer
Clin Adv Hematol Oncol. 2023 Sep;21(9):494-501.ABSTRACTThere are numerous radiation modalities for the definitive treatment of localized prostate cancer. Classic clinical trials have established the basic tenets of treatment approaches, and emerging data have generated new potential avenues of treatment that optimize the therapeutic ratio by increasing prostate cancer tumor control while minimizing treatment-related toxicity. In the definitive setting, the selection of the optimal radiation therapy approach depends largely on the appropriate up-front risk stratification of men with prostate cancer, with greater intensifica...
Source: Clinical Prostate Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Luca F Valle Amar U Kishan Antonio Franco Ting Martin Ma John Nikitas Matthew Farrell Albert J Chang Nicholas G Nickols Michael L Steinberg Source Type: research
Definitive ablative stereotactic partial breast irradiation in early stage inoperable breast cancer
CONCLUSIONS: Our case series suggests that definitive ablative radiation therapy may serve as a safe and effective treatment option for non-operable patients with early stage breast cancer. The observed durable treatment responses and minimal toxicity support the potential of this approach. Furthermore, a longer interval between ablative radiation therapy and surgery may enhance treatment response, potentially leading to increased complete pathologic response rates.PMID:37648809 | DOI:10.1007/s00432-023-05053-x
Source: Clinical Breast Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Mihailo Miljanic Chika Nwachukwu Assal Rahimi Source Type: research
