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Vaccination: Veterinary Vaccinations
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Total 7225 results found since Jan 2013.
Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals
Biologicals. 2023 Jul 19;83:101696. doi: 10.1016/j.biologicals.2023.101696. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Food and Drug Administration (FDA), and the European Directorate for the Quality of Medicines and Healthcare (EDQM) co-organized the "3rd Conference on Next-generation Sequencing for Adventitious Virus Detection in Biologics for Humans and Animals", which was held on September 27-28, 20...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 21, 2023 Category: Biotechnology Authors: Arifa S Khan Laurent Mallet Johannes Bl ümel Jean-Pol Cassart Ivana Knezevic Siemon H S Ng Michael Wall Miia Jakava-Viljanen Carine Logvinoff Ana Goios Pieter Neels Source Type: research
Examination of the cross-reactivity between vaccinia virus Tiantan strain and monkeypox virus
CONCLUSIONS: Sera of vaccinia virus-vaccinated rabbits exhibited cross-reactivity with viral antigens of monkeypox virus. Potential in improving the accuracy of antigen discovery while reducing the lengthy work needed for the screening as BLI method possesses, it contributes greatly to the rapid preliminary evaluation of immune response generated by vaccines.PMID:37473582 | DOI:10.1016/j.jviromet.2023.114772
Source: Journal of Virological Methods - July 20, 2023 Category: Virology Authors: Qiufang Huang Yuwei Wang Tingting Zhao Yinan Wang Xiaojie Wang Shishi Li Wenhao Su Xiuxiu Ren Xiaohuan Zhang Jingjing Liu Jiangbo Wei Source Type: research
Evaluation of a viral transcriptome Next Generation Sequencing assay as an alternative to animal assays for viral safety testing of cell substrates
Vaccine. 2023 Jul 17:S0264-410X(23)00831-9. doi: 10.1016/j.vaccine.2023.07.019. Online ahead of print.ABSTRACTThe viral safety of biological products is ensured by tests throughout the production chain, and, for certain products, by steps in the manufacturing process enabling the elimination or inactivation of viruses. Current testing programs include sample inoculation in animals and embryonic eggs. Following the 3Rs principles of replacement, reduction, and refinement of animal-use methods, such techniques are intended to be replaced not only for ethical reasons but also because of their inherent technical limitations, t...
Source: Vaccine - July 19, 2023 Category: Allergy & Immunology Authors: Pascale Beurdeley-Fehlbaum Matthew Pennington Nicolas H égerlé M élanie Albert Amy Bennett Justine Cheval Allison Clark St éphane Cruveiller C éline Desbrousses Janalyn Frederick Edwige Gros Kathryn Hunter Tareq Jaber Madison Gaiser Oph élie Jouffro Source Type: research
Long-term monitoring of immune response to recombinant lumpy skin disease virus in dairy cattle from small-household farms in western Thailand
This study elucidated immune responses in dairy cattle herd affected by recombinant LSDV.PMID:37467568 | DOI:10.1016/j.cimid.2023.102008
Source: Comparative immunology, microbiology and infectious diseases. - July 19, 2023 Category: Allergy & Immunology Authors: Nutthakarn Suwankitwat Kultyarat Bhakha Lamul Molee Tapanut Songkasupa Kanokwan Puangjinda Tapakorn Chamchoy Orapun Arjkumpa Bandit Nuansrichay Smit Srisomrun Phitcha Pongphitcha Porntippa Lekcharoensuk Pipat Arunvipas Source Type: research
Evaluation of a viral transcriptome Next Generation Sequencing assay as an alternative to animal assays for viral safety testing of cell substrates
Vaccine. 2023 Jul 17:S0264-410X(23)00831-9. doi: 10.1016/j.vaccine.2023.07.019. Online ahead of print.ABSTRACTThe viral safety of biological products is ensured by tests throughout the production chain, and, for certain products, by steps in the manufacturing process enabling the elimination or inactivation of viruses. Current testing programs include sample inoculation in animals and embryonic eggs. Following the 3Rs principles of replacement, reduction, and refinement of animal-use methods, such techniques are intended to be replaced not only for ethical reasons but also because of their inherent technical limitations, t...
Source: Vaccine - July 19, 2023 Category: Allergy & Immunology Authors: Pascale Beurdeley-Fehlbaum Matthew Pennington Nicolas H égerlé M élanie Albert Amy Bennett Justine Cheval Allison Clark St éphane Cruveiller C éline Desbrousses Janalyn Frederick Edwige Gros Kathryn Hunter Tareq Jaber Madison Gaiser Oph élie Jouffro Source Type: research
Induced protection from a CCHFV-M DNA vaccine requires CD8 < sup > + < /sup > T cells
Virus Res. 2023 Jul 15:199173. doi: 10.1016/j.virusres.2023.199173. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever (CCHF) is a World Health Organization prioritized disease because its broad distribution and severity of disease make it a global health threat. Despite advancements in preclinical vaccine development for CCHF virus (CCHFV), including multiple platforms targeting multiple antigens, a clear definition of the adaptive immune correlates of protection is lacking. Levels of neutralizing antibodies in vaccinated animal models do not necessarily correlate with protection, suggesting that cellular immun...
Source: Virus Research - July 17, 2023 Category: Virology Authors: Joseph W Golden Collin J Fitzpatrick John J Suschak Tamara L Clements Keersten M Ricks Mariano Sanchez-Lockhart Aura R Garrison Source Type: research
Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate
Vaccine. 2023 Jul 15:S0264-410X(23)00820-4. doi: 10.1016/j.vaccine.2023.07.008. Online ahead of print.ABSTRACTThe continuing high global incidence of COVID-19 and the undervaccinated status of billions of persons strongly motivate the development of a new generation of efficacious vaccines. We have developed an adjuvanted vaccine candidate, PHH-1V, based on a protein comprising the receptor binding domain (RBD) of the Beta variant of SARS-CoV-2 fused in tandem with the equivalent domain of the Alpha variant, with its immunogenicity, safety and efficacy previously demonstrated in mouse models. In the present study, we immun...
Source: Vaccine - July 17, 2023 Category: Allergy & Immunology Authors: Alexandra Moros Antoni Prenafeta Antonio Barreiro Eva Perozo Alex Fern ández Manuel Ca ñete Luis Gonz ález Carme Garriga Edwards Pradenas Silvia Marfil Juli à Blanco Paula Cebollada Rica Marta Sister é-Oró Andreas Meyerhans Teresa Prat Caba ñas Ric Source Type: research
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice
In this study, we evaluated an immunotherapy protocol in a murine model by combining recombinant (r)LiHyp1 (a hypothetical amastigote-specific Leishmania protein protective against Leishmania infantum infection), with monophosphoryl-lipid A (MPLA) as adjuvant and amphotericin B (AmpB) as reference antileishmanial drug. We used this protocol to treat L. infantum infected-BALB/c mice, and parasitological, immunological and toxicological evaluations were performed at 1 and 30 days after treatment. Results showed that mice treated with rLiHyp1/MPLA/AmpB presented the lowest parasite burden in all organs evaluated, when both a ...
Source: Acta Tropica - July 15, 2023 Category: Infectious Diseases Authors: Daniela P Lage V ívian T Martins Danniele L Vale Camila S Freitas Breno L Pimenta Gabriel J L Moreira Fernanda F Ramos Isabela A G Pereira Raquel S Bandeira Marcelo M de Jesus Fernanda Ludolf Grasiele S V Tavares Miguel A Ch ávez-Fumagalli Bruno M Roatt Source Type: research
