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Total 1275 results found since Jan 2013.

Krebs von den Lungen-6 (KL-6) in cerebrospinal fluid from neurosarcoidosis patients
DISCUSSION: KL-6 is a high MW protein, under physiological conditions it is unlikely to cross the blood-brain barrier. We found KL-6 in CSF from NS and not from ND and DM patients. The finding sustains the specificity of changes in KL-6 in this granulomatous disease, suggesting it as a candidate biomarker for recognition of NS.PMID:37382078 | DOI:10.36141/svdld.v40i2.12900
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - June 29, 2023 Category: Respiratory Medicine Authors: Silvia Bocci Miriana D'Alessandro Laura Bergantini Alfonso Cerase Monica Ulivelli Paola Rottoli Dalila Cavallaro Sara Gangi Elena Bargagli Fabio Giannini Source Type: research

Neurosarcoidosis in an adult man with a family history of MS: A case report
Key clinical messageAccording to this report, a biopsy revealed a diagnosis of neurosarcoidosis in a patient with a history of MS. The development of the disease can be slowed down by early diagnosis and appropriate treatment.AbstractNeurosarcoidosis is a rare type of sarcoidosis that affects the central nervous system (CNS). Herein, we present a case of neurosarcoidosis with a history of multiple sclerosis (MS). Based on the pathological findings of the biopsy, a diagnosis of neurosarcoidosis was established. The administration of appropriate treatment at an early stage can assist in decelerating its progression.
Source: Clinical Case Reports - June 23, 2023 Category: General Medicine Authors: Omid Mirmosayyeb, Mahtab Mohammadzamani, Sara Bagherieh, Elham Moases Ghaffary, Elham Sadat Azimi, Aysa Shaygannejad, Vahid Shaygannejad Tags: CASE REPORT Source Type: research

Comparison between radiometry and spectrophotometry for the determination of angiotensin-converting enzyme activity in cerebrospinal fluid
Ann Biol Clin (Paris). 2023 Jun 17;81(3). doi: 10.1684/abc.2023.1809. Online ahead of print.ABSTRACTDetermination of angiotensin-converting enzyme (ACE) activity in cerebrospinal fluid (CSF) can help for establishing the diagnosis of neurosarcoidosis. We investigated the performance characteristics of two assays for ACE determination in 57 CSF, radiometry with [glycine-1-14C] benzoyl-L-histidyl-L-leucine and spectrophotometry with furylacryloyl-phenylalanyl-L-glycyl-L-glycine (FAPGG) as substrates. We compared both kinetic assays to an ELISA specific for human ACE. Within run and between run imprecisions were 14-17% for ra...
Source: Annales de Biologie Clinique - June 17, 2023 Category: Biochemistry Authors: Ludmia Taibi B énédicte Bénéteau-Burnat Michel Vaubourdolle Bruno Baudin Source Type: research