Sarcoidosis-Associated Sensory Ganglionopathy and Harlequin Syndrome: A Case Report
Conclusions: This case report demonstrates the possible autoimmune origin of both sensory ganglionopathy and Harlequin syndrome. It suggests that an autoimmune etiology for these disorders should be considered and the diagnostic workup should include screening for the most common autoimmune conditions.PMID:37629785 | PMC:PMC10456357 | DOI:10.3390/medicina59081495
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Ieva Navickait ė Migl ė Ališauskienė Sandra Petrauskien ė Gintar ė Žemgulytė Source Type: research

Left ‐dominant arrhythmogenic cardiomyopathy due to desmoplakin mutation: a case report
AbstractThe case of a 49-year-old man with acute onset of heart failure is presented. The initial work-up showed a dilated cardiomyopathy with severely reduced left ventricular ejection fraction. In the differential diagnostic process, hypertensive, ischaemic, and valvular aetiologies were discarded. Subsequently, a cardiac magnetic resonance revealed global hypokinesis and inferior and anterior subepicardial fibrosis. Once differential diagnoses of subepicardial fibrosis (myocarditis, sarcoidosis, and Chagas disease) were discarded, a genetic panel was performed, resulting in a heterozygous mutation of desmoplakin (DSP) g...
Source: ESC Heart Failure - August 26, 2023 Category: Cardiology Authors: Gustavo A. Lemus Barrios, Jose P. Lopez ‐Lopez, Stephany Barbosa‐Balaguera, Alejandro Mariño Correa Tags: Case Report Source Type: research

Gastric Sarcoidosis Flare After Years of Remission Following COVID Infection
Source: Digestive Diseases and Sciences - August 24, 2023 Category: Gastroenterology Source Type: research

The causal relationship between multiple autoimmune diseases and nasal polyps
ConclusionSpecific conclusions regarding the causal effects of multiple autoimmune diseases on nasal polyps are the same as above. By comparing results between different genders, we have initially observed the sex bimodality in the causal effects between autoimmune diseases and nasal polyps, with those on male nasal polyps being stronger than those on female nasal polyps. Our study lays a solid foundation for further research in the future, not only helping identify individuals susceptible to nasal polyps early but also improving our understanding of the immunopathogenesis of these heterogeneous diseases.
Source: Frontiers in Immunology - August 24, 2023 Category: Allergy & Immunology Source Type: research

Sex differences in cardiac sarcoidosis
Sarcoidosis, first described in 1869 by Dr James Hutchinson, is a multisystem inflammatory granulomatous disease of unknown aetiology, most commonly affecting the lungs, with approximately 5% of patients having clinically significant cardiac involvement. Evidence suggests a higher prevalence of cardiac sarcoidosis (CS) in women, African–Americans and the Japanese population (almost 60%).1 Furthermore, cardiac involvement is responsible for 25% of deaths in patients with sarcoidosis in the USA and up to 85% in Japan. Despite the recognition of CS by Bernstein2 over 90 years ago, data are lacking due to the rarity of t...
Source: Heart - August 24, 2023 Category: Cardiology Authors: Griffin, J. M. Tags: Editorials Source Type: research

Sex differences in clinical characteristics and prognosis of patients with cardiac sarcoidosis
Conclusion Approximately two-thirds of patients with CS were females, with a peak age of approximately 60 years at clinical diagnosis in both sexes; male patients were younger than female patients. Male patients had a significantly higher risk of pFVAEs than female patients. Trial registration number UMIN000034974.
Source: Heart - August 24, 2023 Category: Cardiology Authors: Iso, T., Maeda, D., Matsue, Y., Dotare, T., Sunayama, T., Yoshioka, K., Nabeta, T., Naruse, Y., Kitai, T., Taniguchi, T., Tanaka, H., Okumura, T., Baba, Y., Minamino, T. Tags: Heart failure and cardiomyopathies Source Type: research

Gastric Sarcoidosis Flare After Years of Remission Following COVID Infection
Source: Digestive Diseases and Sciences - August 23, 2023 Category: Gastroenterology Source Type: research

Diagnoses and treatments for participants with interstitial lung abnormalities detected in the Yorkshire Lung Screening Trial
DISCUSSION: Lung cancer screening detects clinically significant cases of ILD allowing early commencement of disease-modifying treatment in a proportion of participants. This is the largest screening cohort to report eventual diagnoses and treatments and provides an estimate of the level of clinical activity to be expected by ILD services as lung cancer screening is implemented. Further research is needed to clarify the optimal management of screen-detected ILD.TRIAL REGISTRATION NUMBER: ISRCTN42704678.PMID:37612098 | DOI:10.1136/bmjresp-2022-001490
Source: Respiratory Care - August 23, 2023 Category: Respiratory Medicine Authors: Sara Upperton Paul Beirne Bobby Bhartia Alison Boland Claire Bradley Philip A J Crosbie Mike Darby Claire Eckert Rhian Gabe Neil Hancock Martyn P T Kennedy Jason Lindop Suzanne Rogerson Bethany Shinkins Irene Simmonds Tim J T Sutherland Matthew E J Callis Source Type: research

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