“Hook”ing the diagnosis: Cardiac magnetic resonance imaging remains only one piece of the puzzle in diagnosing giant cell versus sarcoidosis related myocarditis
Inflammatory cardiomyopathies encompass heterogeneous etiologies with often overlapping manifestations [1]. Severity of illness ranges from self-limited to fulminant cardiogenic shock and frequently correlates with etiology. Therefore, accurate identification of the root cause of inflammatory cardiomyopathy should be pursued. However, the sensitivity and specificity of diagnostic modalities, including endomyocardial biopsy (EMB) and cardiac magnetic resonance (CMR) imaging, are limited [2]. In this issue of the journal, Bobbio et al.
Source: International Journal of Cardiology - August 23, 2023 Category: Cardiology Authors: Julianna Czum, Nisha A. Gilotra Tags: Editorial Source Type: research

"Immune mechanisms in fibrotic pulmonary sarcoidosis". P. Weeratunga, D.R. Moller and L-P. Ho. Eur Respir Rev 2022; 31: 220178
Source: European Respiratory Review - August 23, 2023 Category: Respiratory Medicine Tags: Author correction Source Type: research

A systematic review and meta-analysis of the prevalence, incidence, and predictors of atrial fibrillation in cardiac sarcoidosis
The occurrence of atrial arrhythmias, in particular, atrial fibrillation (AF) in patients with cardiac sarcoidosis (CS) are of growing interest in the field of infiltrative cardiomyopathies. Via a systematic review with meta-analysis, we sought to synthesize data on the prevalence, incidence, and predictors of atrial arrhythmias as well as outcomes in patients with CS.
Source: International Journal of Cardiology - August 22, 2023 Category: Cardiology Authors: Carlson Sama, Noah T. Fongwen, Muchi Ditah Chobufo, Yasmin S. Hamirani, James D. Mills, Melissa Roberts, Mark Greathouse, Irfan Zeb, Brian Kazienko, Sudarshan Balla Source Type: research

Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease
Conclusion18F-FDG and68Ga-DOTATOC uptake on PET/CT may be useful for the detection of myocardial inflammation in patients with Chagas cardiomyopathy, and68Ga-DOTATOC uptake may be associated with the presence of malignant arrhythmia, with potential therapeutic implications.
Source: Journal of Nuclear Cardiology - August 21, 2023 Category: Nuclear Medicine Source Type: research

Paradigm shift in myocarditis treatment
J Cardiol. 2023 Aug 17:S0914-5087(23)00203-4. doi: 10.1016/j.jjcc.2023.08.009. Online ahead of print.ABSTRACTAlthough most cases of myocarditis are self-limiting with a gradual improvement in cardiac function, the involvement of myocarditis in sudden cardiac death among children and young adults remains substantial, with rates of 3-17 % and 8.6-12 %, respectively. Moreover, the risk of developing chronic dilated cardiomyopathy ranges from 21 % to 30 % in all cases confirmed by biopsy. Current therapeutic strategies for myocarditis and its complications range from standard supportive care for heart failure and arrhythmias t...
Source: Journal of Cardiology - August 19, 2023 Category: Cardiology Authors: Ulugbek Yakhshimurodov Kizuku Yamashita Takuji Kawamura Masashi Kawamura Shigeru Miyagawa Source Type: research

A case of endobronchial metastasis of colon cancer mimics sarcoidosis, and a review of related literature
CONCLUSION: EBM should be distinguished from primary lung cancer, sarcoidosis.PMID:37594535 | DOI:10.1007/s00432-023-05214-y
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Hui Lv Yi Shao Qiu-Song Chen Wen-Jing Song Li-Na Peng Dian-Sheng Zhong Source Type: research

Cardiac Sarcoidosis: Updated Insights on Epidemiology and Diagnostic Criteria
Cardiac sarcoidosis is a rare but potentially life-threatening condition characterized by the formation of noncaseating granulomas in the myocardium. The diagnosis of cardiac sarcoidosis is challenging because of its diverse and nonspecific clinical presentation. The disease is generally an uncommon manifestation of systemic sarcoidosis involving the heart and the pericardium, although isolated cardiac sarcoidosis can occur in patients who do not have evidence of sarcoidosis in other organs (this event may occur in up to 25% of cardiac sarcoidosis cases).
Source: The American Journal of Cardiology - August 18, 2023 Category: Cardiology Authors: Gaetano Santulli Tags: Editorial Source Type: research

GSE156397 Activity of the GHRH Antagonist MIA-602 and its Underlying Mechanisms of Action in sarcoidosis
Contributors : Anthony J Griswold ; Mehdi MirsaeidiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGrowth hormone releasing hormone (GHRH) is a potent stimulator of growth hormone secretion from pituitary gland. Although GHRH is essential for growth of immune cells, the regulatory effects of its antagonist in granulomatous disease remains unknown. The goal is to evaluate the expression of GHRH receptor in human tissue with sarcoidosis granuloma and demonstrate the anti-inflammatory effects of MIA-602 (a GHRH antagonist) in in vitro and in vivo studies. Granulomatous reaction in the mo...
Source: GEO: Gene Expression Omnibus - August 16, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Association of longitudinal cardiac troponin trajectory with adverse events in patients with cardiac sarcoidosis
This study aimed to clarify whether longitudinal cardiac troponin levels were associated with adverse events in patients with CS.
Source: International Journal of Cardiology - August 15, 2023 Category: Cardiology Authors: Sho Kazui, Sakae Takenaka, Toshiyuki Nagai, Yoshiya Kato, Hirokazu Komoriyama, Yuta Kobayashi, Akinori Takahashi, Kiwamu Kamiya, Takuma Sato, Atsushi Tada, Yutaro Yasui, Michikazu Nakai, Takahiro Sato, Ichizo Tsujino, Satoshi Konno, Toshihisa Anzai Source Type: research

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