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Total 325 results found since Jan 2013.

Comment: The trouble with "n" in normal-pressure hydrocephalus
Idiopathic normal-pressure hydrocephalus (iNPH) is a reversible syndrome of gait impairment, dementia, and incontinence that affects persons over 65 years of age.1 Currently, the only effective treatment is surgical implantation of a shunt2; however, the need for pharmacologic adjunctive treatments was noted at the 2005 NIH workshop on hydrocephalus.3
Source: Neurology - April 14, 2014 Category: Neurology Authors: Williams, M. A. Tags: Hydrocephalus ARTICLE Source Type: research

Protocolizing the Workup for Idiopathic Normal Pressure Hydrocephalus Improves Outcomes
Conclusions Implementing an INPH Protocol leads to standardized and more extensive assessment and better patient selection for and subsequent outcomes from shunting, specifically regarding gait.
Source: Neurology Clinical Practice - August 9, 2021 Category: Neurology Authors: Acosta, L. M. Y., Stubblefield, K., Conwell, T., Espaillat, K., Koons, H., Konrad, P., Fang, J., Kirshner, H., Davis, T. Tags: Hydrocephalus, Diagnostic test assessment, All Clinical Neurology, Gait disorders/ataxia, Assessment of cognitive disorders/dementia Research Source Type: research

Can Shunt Response in Patients with Idiopathic Normal Pressure Hydrocephalus Be Predicted from Preoperative Brain Imaging? A Retrospective Study of the Diagnostic Use of the Normal Pressure Hydrocephalus Radscale in 119 Patients ADULT BRAIN
CONCLUSIONS: The Normal Pressure Hydrocephalus Radscale showed moderate discrimination for shunt response but cannot, on its own, be used for selecting patients with idiopathic normal pressure hydrocephalus for shunt surgery.
Source: American Journal of Neuroradiology - February 4, 2022 Category: Radiology Authors: Carlsen, J. F., Backlund, A. D. L., Mardal, C. A., Taudorf, S., Holst, A. V., Munch, T. N., Hansen, A. E., Hasselbalch, S. G. Tags: ADULT BRAIN Source Type: research

Reappraisal of Radionuclide Cisternography in the diagnosis of chronic hydrocephalus – a single institution report
We present our retrospective clinical experience with a series of patients with signs and symptoms of chronic hydrocephalus that were investigated by radionuclide cisternography (RC) and discuss the method's possible contemporary role. During the past five years, RC was used during the investigation of 12 possible hydrocephalus patients (5 male, 7 female, ages 26 to 77years, mean 59.5, std 18.19). The patients' symptoms ranged from headache to gait disturbance, dementia and urine incontinence. Patients were investigated with CT and MRI scans and had a RC examination using In-111-DTPA. According to the RC results the patien...
Source: Interdisciplinary Neurosurgery - June 16, 2015 Category: Neurosurgery Source Type: research

Higher prevalence of idiopathic normal pressure hydrocephalus ‐like MRI features in progressive supranuclear palsy: An imaging reminder of atypical parkinsonism
ConclusionsThis study demonstrates that the presence of NPH-like MRI features is much higher in PSP patients, and this tendency is decided upon the determination of parkinsonism subtype. Sharing pathophysiological characteristics in these two diseases is implied. More diagnostic tools are needed to better differentiate the two diseases and decide the treatment. To closely observe hydrocephalic parkinsonism patients and well inform the possible limited shunting benefits if PSP core features appear, will be more pivotal and practical at present clinical practice.
Source: Brain and Behavior - January 13, 2023 Category: Neurology Authors: Mu ‐Hui Fu, Chih‐Cheng Huang, Kay L. H. Wu, Ying‐Fa Chen, Yu‐Chih Kung, Cheng‐Chang Lee, Jia‐Shou Liu, Min‐Yu Lan, Yung‐Yee Chang Tags: ORIGINAL ARTICLE Source Type: research

MR Elastography Demonstrates Increased Brain Stiffness in Normal Pressure Hydrocephalus ADULT BRAIN
CONCLUSIONS: This study demonstrates increased brain stiffness in patients with normal pressure hydrocephalus compared with age- and sex-matched healthy controls; these findings should motivate future studies investigating the use of MR elastography for this condition and the efficacy of shunt therapy.
Source: American Journal of Neuroradiology - March 14, 2016 Category: Radiology Authors: Fattahi, N., Arani, A., Perry, A., Meyer, F., Manduca, A., Glaser, K., Senjem, M. L., Ehman, R. L., Huston, J. Tags: ADULT BRAIN Source Type: research

Lower urinary tract dysfunction in normal pressure hydrocephalus: Review of the literature.
CONCLUSION: There is actually an insufficient concern about urinary symptoms in normal pressure hydrocephalus. This article highlights the importance of a harmonization of neuro-urological practices in the pre-therapeutic evaluation of patients suffering from normal pressure hydrocephalus. PMID: 27816462 [PubMed - as supplied by publisher]
Source: Progres en Urologie - November 7, 2016 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.
Authors: Nakajima M, Yamada S, Miyajima M, Ishii K, Kuriyama N, Kazui H, Kanemoto H, Suehiro T, Yoshiyama K, Kameda M, Kajimoto Y, Mase M, Murai H, Kita D, Kimura T, Samejima N, Tokuda T, Kaijima M, Akiba C, Kawamura K, Atsuchi M, Hirata Y, Matsumae M, Sasaki M, Yamashita F, Aoki S, Irie R, Miyake H, Kato T, Mori E, Ishikawa M, Date I, Arai H, research committee of idiopathic normal pressure hydrocephalus Abstract Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of gr...
Source: Neurologia Medico-Chirurgica - January 20, 2021 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Endoscopic third ventriculostomy (ETV) for idiopathic normal pressure hydrocephalus (iNPH).
CONCLUSIONS: The only randomised trial of ETV for iNPH compares it to an intervention which is not a standard practice (VP shunting using a non-programmable valve). The evidence from this study is inconclusive and of very low quality. Clinicians should be aware of the limitations of the evidence. There is a need for more robust research on this topic to be able to determine the effectiveness of ETV in patients with iNPH. PMID: 26222251 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 29, 2015 Category: Journals (General) Authors: Tudor KI, Tudor M, McCleery J, Car J Tags: Cochrane Database Syst Rev Source Type: research

Large aneurysm of basilar artery tip mimicking midbrain tumor and causing unilateral obstructive hydrocephalus: a case report and technical note.
In conclusion, large basilar tip aneurysms associated with obstructive hydrocephalus are rare and best treated by a combination of endovascular obliteration and cerebrospinal fluid ventricular diversion. The possibility of such an aneurysm should always be considered on the differential diagnosis of cerebral ventricular growths. PMID: 32724289 [PubMed - in process]
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Idiopathic Normal Pressure Hydrocephalus Presenting as Psychosis
Conclusions: All the patients had psychosis much before other features of iNPH developed. One of the patient's psychosis was temporally associated with onset and offset of hydrocephalus, thereby strongly supporting the causative nature of iNPH. iNPH though rare can be one of the causes for late onset secondary psychosis.
Source: Neurology India - October 30, 2021 Category: Neurology Authors: Robert Mathew NU Archana S Sheetal Source Type: research

Increased Levels of Kynurenic Acid in the Cerebrospinal Fluid in Patients with Hydrocephalus.
CONCLUSION: The aging process is related to elevated CSF levels of KYNA, L-KYN, and L-TRP levels. There are significant differences in clinical parameters between the two forms of hydrocephalus and these differences might have diagnostic utility. The occurrence of dementia in patients with either form of hydrocephalus might be at least partly related to elevated KYNA levels in the CNS and/or periphery. PMID: 31059212 [PubMed - in process]
Source: Neuro-Signals - May 8, 2019 Category: Neurology Authors: Kepplinger B, Baran H, Kronsteiner C, Reuss J Tags: Neurosignals Source Type: research

Idiopathic fourth ventricular outlet obstruction misdiagnosed as normal pressure hydrocephalus: A cautionary case.
Conclusion: Here, we describe an idiopathic case initially misdiagnosed as normal pressure hydrocephalus. The present case emphasizes the necessity of CISS sequences and fluoroscopic dynamic cisternography for suspected cases of fourth ventricular outlet obstruction as these diagnostic tests may guide surgical management and lead to superior patient outcomes. PMID: 33093982 [PubMed]
Source: Surgical Neurology International - October 25, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Post-hemorrhagic hydrocephalus presenting as cauda equina syndrome in a patient with spinal dysraphism
We report on a 32-year-old woman with remotely repaired spinal defect who experienced subarachnoid hemorrhage and underwent anterior communicating artery aneurysm clipping. Post-operatively, she developed urinary and fecal incontinence as the sole presenting symptom of communicating post-hemorrhagic hydrocephalus. New neurological deficits in this population can also be attributed to recurrent cord tethering or syrinx, both of which were demonstrated on her lumbar spine MRI, but her incontinence resolved with external ventricular drain placement and cerebrospinal fluid diversion. There are few case reports of patients with...
Source: Journal of Clinical Neuroscience - December 9, 2015 Category: Neuroscience Source Type: research

MRI of Normal Pressure Hydrocephalus
Publication date: Available online 20 January 2016 Source:Seminars in Ultrasound, CT and MRI Author(s): William G. Bradley Normal Pressure Hydrocephalus (NPH) is a syndrome found in the elderly which is characterized by ventriculomegaly and deep white matter ischemia (DWMI) on MRI and the clinical triad of gait disturbance, dementia and urinary incontinence. NPH has been estimated to account for up to 10% of cases of dementia and is significant because it is treatable by ventriculoperitoneal shunting (VPS). Patients with a known cause of chronic communicating hydrocephalus, ie, meningitis or hemorrhage, tend to respond ...
Source: Seminars in Ultrasound, CT and MRI - January 21, 2016 Category: Radiology Source Type: research