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Specialty: General Medicine

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Total 461 results found since Jan 2013.

Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP
Conclusions: Kaolin-hydrocephalus can accelerate intraneuronal Abeta40 accumulation and vascular pathology in tgAPP21 rats. In addition, disrupted CSF production and reduced CSF turnover results in impaired Abeta clearance and accelerated vascular pathology in chronic hydrocephalus. The high co-morbidity seen in NPH, AD and CVD is likely not to be an age-related coincidence, but rather a convergence of pathologies related to diminished CSF clearance.
Source: BioMed Central - January 24, 2015 Category: Journals (General) Authors: Gerald D SilverbergMiles C MillerCrissey L PascaleIlias N CaralopoulosYuksel AgcaCansu AgcaEdward G Stopa Source Type: research

Cerebrospinal fluid absorption block at the vertex in chronic hydrocephalus: obstructed arachnoid granulations or elevated venous pressure?
Conclusions: The size of the venous sinuses normally does not change over the age range investigated but sinus pressure is reduced proportional to an age-related blood flow reduction. Hydrocephalus is associated with much smaller sinuses than normal and an elevation in venous pressure may explain the lack of CSF absorption into the arachnoid granulations in chronic hydrocephalus.
Source: BioMed Central - May 23, 2014 Category: Journals (General) Authors: Grant A BatemanSabbir H Siddique Source Type: research

A proposed role for efflux transporters in the pathogenesis of hydrocephalus.
This article summarizes the existing evidence to support the role of efflux transporters in the pathogenesis of hydrocephalus. The location of p-gp along the pathways of macromolecular clearance and the broad substrate specificity of this abundant transporter to a variety of different macromolecules are reviewed. Involvement of p-gp in the transport of amyloid beta in Alzheimer disease and its relation to normal pressure hydrocephalus is reviewed. Finally, individual variability of p-gp expression might explain the variability in the development of hydrocephalus following intraventricular hemorrhage. PMID: 25165050 [P...
Source: Croatian Medical Journal - August 28, 2014 Category: Journals (General) Authors: Krishnamurthy S, Tichenor MD, Satish AG, Lehmann DB Tags: Croat Med J Source Type: research

Endoscopic third ventriculostomy (ETV) for idiopathic normal pressure hydrocephalus (iNPH).
CONCLUSIONS: The only randomised trial of ETV for iNPH compares it to an intervention which is not a standard practice (VP shunting using a non-programmable valve). The evidence from this study is inconclusive and of very low quality. Clinicians should be aware of the limitations of the evidence. There is a need for more robust research on this topic to be able to determine the effectiveness of ETV in patients with iNPH. PMID: 26222251 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 29, 2015 Category: Journals (General) Authors: Tudor KI, Tudor M, McCleery J, Car J Tags: Cochrane Database Syst Rev Source Type: research

Hydrocephalus in children
Publication date: Available online 6 August 2015 Source:The Lancet Author(s): Kristopher T Kahle, Abhaya V Kulkarni, David D Limbrick, Benjamin C Warf Hydrocephalus is a common disorder of cerebral spinal fluid (CSF) physiology resulting in abnormal expansion of the cerebral ventricles. Infants commonly present with progressive macrocephaly whereas children older than 2 years generally present with signs and symptoms of intracranial hypertension. The classic understanding of hydrocephalus as the result of obstruction to bulk flow of CSF is evolving to models that incorporate dysfunctional cerebral pulsations, brain c...
Source: The Lancet - August 7, 2015 Category: Journals (General) Source Type: research

Endoscopic third ventriculostomy for hydrocephalus in a patient with Klippel –Feil syndrome: a case report
Key Clinical Message A patient with Klippel–Feil syndrome presented with hydrocephalus secondary to intraventricular hemorrhage. Fusion of the cervical vertebrae may have impeded cerebrospinal fluid flow. Change in the properties of cerebrospinal fluid flow after hemorrhage may have induced noncommunicating hydrocephalus. Endoscopic third ventriculostomy was effective for the treatment of hydrocephalus associated with Klippel–Feil syndrome. A patient with Klippel–Feil syndrome presented with hydrocephalus secondary to intraventricular hemorrhage. Fusion of the cervical vertebrae may have impeded cerebrospinal fluid ...
Source: Clinical Case Reports - July 1, 2017 Category: General Medicine Authors: Tomohisa Ishida, Takashi Inoue, Miki Fujimura, Yoshiteru Shimoda, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga Tags: Case Report Source Type: research

Ventriculo-peritoneal shunting devices for hydrocephalus.
CONCLUSIONS: Standard shunt valves for hydrocephalus compared to anti-syphon or self-adjusting CSF flow-regulating valves may cause little to no difference on the main outcomes of this review, however we are very uncertain due to the low to very low certainty of evidence. Similarly, different types of standard valves and external differential programmable pressure valves versus non-programmable valves may be associated with similar outcomes. Nevertheless, this review did not include valves with the latest technology, for which we need high-quality randomised controlled trials focusing on patient-important outcomes includi...
Source: Cochrane Database of Systematic Reviews - June 15, 2020 Category: General Medicine Authors: Garegnani L, Franco JV, Ciapponi A, Garrote V, Vietto V, Portillo Medina SA Tags: Cochrane Database Syst Rev Source Type: research

Large aneurysm of basilar artery tip mimicking midbrain tumor and causing unilateral obstructive hydrocephalus: a case report and technical note.
In conclusion, large basilar tip aneurysms associated with obstructive hydrocephalus are rare and best treated by a combination of endovascular obliteration and cerebrospinal fluid ventricular diversion. The possibility of such an aneurysm should always be considered on the differential diagnosis of cerebral ventricular growths. PMID: 32724289 [PubMed - in process]
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Management and outcomes of myelomeningocele-associated hydrocephalus in low-income and middle-income countries: a systematic review and meta-analysis protocol
This study aims to review and compare the management and outcomes of infant MMC-associated hydrocephalus in LMICs and high-income countries. Methods and analysis This systematic review and meta-analysis will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The following databases will be searched without restrictions on language, publication date or country of origin: EMBASE, MEDLINE, The Cochrane Library, Global Index Medicus, African Journals Online and SciELO. All peer-reviewed studies of primary data reporting management and outcomes of infant MMC-associated hydrocephalus ...
Source: BMJ Open - February 7, 2023 Category: General Medicine Authors: Takoutsing, B. D., Yanez Touzet, A., Park, J. J., Lee, S. H., Bligh, E. R., Egiz, A., Gillespie, C. S., Figaji, A., On behalf of the Neurology and Neurosurgery Interest Group Tags: Open access, Neurology Source Type: research

Intraoperative precautionary insertion of external ventricular drainage catheters in posterior fossa tumors presenting with hydrocephalus
Conclusion Intra-operative insertion of EVD catheter during surgery of posterior fossa tumors, as it allows better control of the ICT during surgery if needed, provides a life saving emergency CSF drainage outlet if tumor resection fails to resolve HC or for the occurrence of de novo HC, and finally it provides adequate control of CSF leak in cases with supratentorial ventriculomegaly, where the use of lumbar drains may be hazardous. Intraoperative drainage prevents possible complications met with early CSF diversion. But the application of this technique should better be restricted to midline posterior fossa tumors relate...
Source: Alexandria Journal of Medicine - November 15, 2014 Category: Journals (General) Source Type: research

Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans.
CONCLUSIONS: The results suggest that atrophy in the parietal lobes and the cerebellum of hospitalized older adult military veterans may be associated with an elevated risk of delirium when compared with age, race, and sex-matched control veterans. Continuing efforts are needed to clarify the role of atrophy during delirium in the veteran and nonveteran older adult population to reduce progressive frailty and decreased quality of life secondary to hospital and posthospital-discharge delirium. PMID: 28575905 [PubMed - in process]
Source: Southern Medical Journal - June 3, 2017 Category: General Medicine Tags: South Med J Source Type: research

A newly described imaging finding for Idiopathic Normal Pressure Hydrocephalus: Can Hummingbird sign contribute to the diagnosis?
Conclusion Hummingbird sign can be used to support the diagnosis of idiopathic normal pressure hydrocephalus in addition to other radiological findings. A significant correlation between vascular compression and hummingbird sign in the patient group may explain the morphological changes in the mesencephalon that resemble the Hummingbird sign which was previously described for progressive supranuclear palsy.PMID:34565136 | DOI:10.3906/sag-2107-86
Source: Turkish Journal of Medical Sciences - September 27, 2021 Category: General Medicine Authors: Ba şak Atalay Umut Per çem Orhan Söylemez H üseyin Yildiz Source Type: research

At what age is hydrocephalus detected, and what is the role of head circumference measurements?
To investigate at what age hydrocephalus is detected and to assess the role of head circumference measurements in detecting hydrocephalus, we performed a retrospective chart review in children with hydrocephalus treated in a tertiary paediatric hospital in the Netherlands. The study group contained 146 patients; 38 patients (31%) were referred because of abnormalities in head circumference. Eighty-nine per cent of the patients were detected in the first year of life. After this period, no patients were referred because of an abnormal head circumference. Therefore, head circumference measurements seem to have little value f...
Source: The European Journal of Public Health - January 24, 2014 Category: Journals (General) Authors: Breuning-Broers, J. M., Deurloo, J. A., Gooskens, R. H., Verkerk, P. H. Tags: Childhood and adolescent health Source Type: research

Endoscopic management of septated, multiloculated hydrocephalus
Conclusion The treatment of loculated hydrocephalus remains a difficult problem in the practice of neurosurgery, yet neuroendoscopy has yielded encouraging results and may be able to dramatically change the prognosis of this troublesome condition in the near future. So neuroendoscopic surgery can be considered a valid alternative to traditional multiple shunt placement surgery and craniotomy in the management of multiloculated hydrocephalus.
Source: Alexandria Journal of Medicine - October 22, 2014 Category: Journals (General) Source Type: research