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Total 151 results found since Jan 2013.
The dynamic expression of aquaporins 1 and 4 in rats with hydrocephalus induced by subarachnoid haemorrhage.
CONCLUSIONS: AQP1 and AQP4 are remarkably correlated with the severity of hydrocephalus induced by SAH. AQP1 and AQP4 are potential drug targets for developing therapeutic strategies against hydrocephalus.
PMID: 31556577 [PubMed - in process]
Source: Folia Neuropathologica - September 28, 2019 Category: Pathology Authors: Long CY, Huang GQ, Du Q, Zhou LQ, Zhou JH Tags: Folia Neuropathol Source Type: research
Hydrocephalus induced via intraventricular kaolin injection in adult rats.
In this study, we attempted to construct a high-efficiency model of hydrocephalus via intraventricular kaolin injection. Adult male Sprague-Dawley rats were randomly divided into 2 groups: the control group (n = 15) and the experimental group (n = 30). Kaolin was injected into the lateral ventricle of experimental animals. Control rats underwent the same procedure but received sterile saline injection instead of kaolin. All animals with kaolin injection into the lateral ventricle developed hydrocephalus according to magnetic resonance imaging (MRI) results (success rate up to 100%). Also, the Morris water maze (MWM) test d...
Source: Folia Neuropathologica - April 25, 2015 Category: Pathology Authors: Shaolin Z, Zhanxiang W, Hao X, Feifei Z, Caiquan H, Donghan C, Jianfeng B, Feng L, Shanghang S Tags: Folia Neuropathol Source Type: research
The role of L1cam in murine corticogenesis, and the pathogenesis of hydrocephalus
L1cam (L1), one of the cell adhesion molecules belonging to the immunoglobulin superfamily, plays critical roles in neuronal migration, axon growth, guidance, fasciculation, and synaptic plasticity in the central as well as the peripheral nervous system. A number of X‐linked forms of mental retardation have been associated with mutations in the L1 gene, including X‐linked hydrocephalus in humans. Although model mice with different sites of L1 mutation have been studied, the pathogenetic mechanisms of hydrocephalus and mental retardation still remain unsolved. We herein present an overview of the function of L1 in the c...
Source: Pathology International - February 1, 2015 Category: Pathology Authors: Kyoko Itoh, Shinji Fushiki Tags: Review Article Source Type: research
Normal pressure hydrocephalus mimicking Alzheimer's disease: such an infrequent case?
We present a case of NPH that commenced with cognitive deterioration similar to Alzheimer's disease (AD). Motor manifestations (i.e., falls and gait dysfunction) appeared 2.5 years after the initiation of memory problems. Apart from ventricular enlarging, no prominent pathologies were found at brain examination. The prevalence of cases of NPH presenting with memory problems may be underestimated given the traditional view of NPH displaying a clinical triad of gait dysfunction, mental decline of "subcortical" appearance, and incontinence. Careful examination of the structural neuroimaging study in the initial assessment and...
Source: Clinical Neuropathology - July 17, 2013 Category: Pathology Authors: Olazarán J, Martínez MD, Rábano A Tags: Clin Neuropathol Source Type: research
A case of hydrocephalus in a child from early modern period Žumberak, Croatia
ConclusionA diagnosis of the communicating form of hydrocephalus is suggested.SignificanceThis is the first published case of the communicating form of hydrocephalus.LimitationsIt is difficult to determine the specific etiology of this condition based on skeletal remains.
Source: International Journal of Paleopathology - May 29, 2019 Category: Pathology Source Type: research
Maternal mosaicism underlies the inheritance of a rare germline AKT3 variant which is responsible for megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome in two Roma half-siblings.
In conclusion, this is the first report in which maternal germline mosaicism of a rare pathogenic AKT3 variant leads to autosomal dominantly inherited MPPH syndrome.
PMID: 32446860 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - May 20, 2020 Category: Pathology Authors: Szalai R, Melegh BI, Till A, Ripszam R, Csabi G, Acharya A, Schrauwen I, Leal SM, Komoly S, Kosztolanyi G, Hadzsiev K Tags: Exp Mol Pathol Source Type: research
Presence of Cervical Vertebral Anomalies with Concomitant Non-Communicating Hydrocephalus and Multicystic Kidney in a Female Fetus: Where VACTERL-H Meets MURCS
CONCLUSION: We were able to demonstrate how well-defined, standardized volumetric reconstruction of diagnostic views displaying fetal pathology in utero might aid early and precise diagnosis of multi-organ malformations. Application of modern diagnostic imaging tools is helpful in delineation of the most likely diagnoses (VACTERL-H vs. MURCS) as further specified during detailed pathologic work-up and might consequently facilitate individually tailored interdisciplinary counseling, as in the case presented here.PMID:34689682 | DOI:10.1080/15513815.2021.1994068
Source: Fetal and Pediatric Pathology - October 25, 2021 Category: Pathology Authors: Christoph Dracopoulos Michael Gembicki Jann Lennard Scharf Amrei Welp Nadine Berg Jan Weichert Source Type: research
