Effectiveness and Safety of Xen Gel Stent in Glaucoma Surgery: A Systematic Review of the Literature
This study aimed to review the effectiveness and safety of clinical data on XEN-stent in OAG patients with a Synthesis-Without-Meta-analysis (SWiM) methodology. A total of 339 studies were identified following a literature search adhering to PRISMA guidelines and, after evaluation, 96 studies are discussed. XEN63 and XEN45 device data were collected both short and long term. In addition, this document has evaluated different aspects related to the XEN implant, including: its role compared to trabeculectomy; the impact of mitomycin-C dose on clinical outcomes; postoperative management of the device; and the identification o...
Source: The Medical Clinics of North America - August 26, 2023 Category: General Medicine Authors: Carlo Enrico Traverso Roberto G Carassa Antonio Maria Fea Michele Figus Carlo Astarita Benedetta Piergentili Vanessa Vera Stefano Gandolfi Source Type: research

The Genetic Determinants of Axial Length: From Microphthalmia to High Myopia in Childhood
Annu Rev Genomics Hum Genet. 2023 Aug 25;24:177-202. doi: 10.1146/annurev-genom-102722-090617.ABSTRACTThe axial length of the eye is critical for normal visual function by enabling light to precisely focus on the retina. The mean axial length of the adult human eye is 23.5 mm, but the molecular mechanisms regulating ocular axial length remain poorly understood. Underdevelopment can lead to microphthalmia (defined as a small eye with an axial length of less than 19 mm at 1 year of age or less than 21 mm in adulthood) within the first trimester of pregnancy. However, continued overgrowth can lead to axial high myopia (an enl...
Source: Annual Review of Genomics and Human Genetics - August 25, 2023 Category: Genetics & Stem Cells Authors: Daniel Jackson Mariya Moosajee Source Type: research

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