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Photochemical Tissue Bonding of Amnion Allograft Membranes for Peripheral Nerve Repair: A Biomechanical Analysis
Conclusion PTB repairs with commercial noncrosslinked amnion allograft membranes can withstand physiological strain and have comparable performance to repairs with human amnion, which has demonstrated efficacy in vivo. These results indicate the need for further testing of these membranes using in vivo animal model repairs. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Journal of Reconstructive Microsurgery - September 11, 2023 Category: Surgery Authors: King, Nicholas C. McGuire, Kalyn R. Bejar-Chapa, Maria Hoftiezer, Yannick A. J. Randolph, Mark A. Winograd, Jonathan M. Tags: Original Article Source Type: research
Invariant natural killer T cells in lung diseases
Experimental & Molecular Medicine, Published online: 11 September 2023; doi:10.1038/s12276-023-01024-xA small subset of immune cells residing in the lung plays a pivotal part in governing the inflammatory response in a range of pulmonary disorders. Invariant natural killer T (iNKT) cells monitor the blood vessels in the lung for infection or other sources of tissue damage, which cause the cells to release chemical signals that rally a broader immune response. Doo Hyun Chung of Seoul National University, South Korea, and colleagues review the complex role of iNKT cells in determining the severity and outcome of respirat...
Source: Experimental and Molecular Medicine - September 11, 2023 Category: Molecular Biology Authors: Dongjin Jeong Yeon Duk Woo Doo Hyun Chung Source Type: research
Detection of resistance and virulence plasmids in Campylobacter coli and Campylobacter jejuni isolated from North Carolina food animal production, 2018-2019
Food Microbiol. 2023 Dec;116:104348. doi: 10.1016/j.fm.2023.104348. Epub 2023 Aug 11.ABSTRACTCampylobacter remains the leading cause of bacterial foodborne illness in the U.S. and worldwide. Campylobacter plasmids may play a significant role in antimicrobial resistance (AMR) and virulence factor distribution, and potentially drive rapid adaptation. C. coli (n = 345) and C. jejuni (n = 199) isolates collected from live cattle, swine, turkey, and chickens, poultry carcasses at production, and retail meat in N.C. were analyzed to determine plasmid prevalence, extrachromosomal virulence and AMR genes, and the phylogeny of asse...
Source: Food Microbiology - September 9, 2023 Category: Food Science Authors: Dawn M Hull Erin Harrel Lyndy Harden Siddhartha Thakur Source Type: research
Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography-tandem mass spectrometry
Amino Acids. 2023 Sep 10. doi: 10.1007/s00726-023-03315-z. Online ahead of print.ABSTRACTNarcolepsy is a chronic and underrecognized sleep disorder characterized by excessive daytime sleepiness and cataplexy. Furthermore, narcolepsy type 1 (NT1) has serious negative impacts on an individual's health, society, and the economy. Currently, many sleep centers lack the means to measure orexin levels in the cerebrospinal fluid. We aimed to analyze the characteristics of metabolite changes in patients with NT1, measured by ultra-performance liquid chromatography-tandem mass spectrometry. A principal component analysis (PCA), an o...
Source: Amino Acids - September 9, 2023 Category: Biochemistry Authors: Qingqing Zhan Lili Wang Nan Liu Yuqing Yuan Liying Deng Yongmin Ding Fen Wang Jian Zhou Liang Xie Source Type: research
Detection of resistance and virulence plasmids in Campylobacter coli and Campylobacter jejuni isolated from North Carolina food animal production, 2018-2019
Food Microbiol. 2023 Dec;116:104348. doi: 10.1016/j.fm.2023.104348. Epub 2023 Aug 11.ABSTRACTCampylobacter remains the leading cause of bacterial foodborne illness in the U.S. and worldwide. Campylobacter plasmids may play a significant role in antimicrobial resistance (AMR) and virulence factor distribution, and potentially drive rapid adaptation. C. coli (n = 345) and C. jejuni (n = 199) isolates collected from live cattle, swine, turkey, and chickens, poultry carcasses at production, and retail meat in N.C. were analyzed to determine plasmid prevalence, extrachromosomal virulence and AMR genes, and the phylogeny of asse...
Source: Food Microbiology - September 9, 2023 Category: Food Science Authors: Dawn M Hull Erin Harrel Lyndy Harden Siddhartha Thakur Source Type: research
A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses
This study focuses on the hemagglutinin (HA) consensus-based approach towards developing a more broadly protective swine influenza vaccine against various H3 strains circulating in domestic pig populations. By computationally analyzing >1000 swine H3 full-length HA sequences, we generated a consensus H3 and expressed it in the context of influenza A WSN/33 reverse genetics system. The derived recombinant chimeric swine influenza virus with the consensus H3 was inactivated and further evaluated as a potential universal vaccine in pigs. The consensus H3 vaccine elicited broadly active hemagglutination inhibition (HI) anti...
Source: Vaccine - September 9, 2023 Category: Allergy & Immunology Authors: Jieshi Yu Chithra Sreenivasan Zhizhang Sheng Shao-Lun Zhai Jared W Wollman Sisi Luo Chen Huang Rongyuan Gao Zhao Wang Radhey S Kaushik Jane Christopher-Hennings Eric Nelson Ben M Hause Feng Li Dan Wang Source Type: research
Detection of resistance and virulence plasmids in Campylobacter coli and Campylobacter jejuni isolated from North Carolina food animal production, 2018-2019
Food Microbiol. 2023 Dec;116:104348. doi: 10.1016/j.fm.2023.104348. Epub 2023 Aug 11.ABSTRACTCampylobacter remains the leading cause of bacterial foodborne illness in the U.S. and worldwide. Campylobacter plasmids may play a significant role in antimicrobial resistance (AMR) and virulence factor distribution, and potentially drive rapid adaptation. C. coli (n = 345) and C. jejuni (n = 199) isolates collected from live cattle, swine, turkey, and chickens, poultry carcasses at production, and retail meat in N.C. were analyzed to determine plasmid prevalence, extrachromosomal virulence and AMR genes, and the phylogeny of asse...
Source: Food Microbiology - September 9, 2023 Category: Food Science Authors: Dawn M Hull Erin Harrel Lyndy Harden Siddhartha Thakur Source Type: research
Evaluation of dynamics of immune responses and protective efficacy in piglets immunized with an inactivated porcine reproductive and respiratory syndrome vaccine candidate
In this study, we investigated the protective efficacy of an inactivated PRRS virus vaccine candidate and evaluated the differences in PRRSV specific anamnestic response in piglets when challenged with live PRRSV at two different intervals post-immunization. Six-week-old piglets were immunized intramuscularly with an inactivated, Montanide ISA-206 adjuvanted Indian PRRSV isolate, followed by a booster dose at 21 days post-immunization. Homologous live PRRS virus challenge was done on 60 and 180 days post-booster (dpb). We assessed humoral and cell-mediated immune responses at various intervals post-immunization and after c...
Source: Vaccine - September 9, 2023 Category: Allergy & Immunology Authors: Megha Katare Pandey Katherukamem Rajukumar Dhanapal Senthilkumar Subbiah Kombiah Fateh Singh Govindarajulu Venkatesh Manoj Kumar Sangeeta Shrivas Deepali Shrivastava Vijendra Pal Singh Aniket Sanyal Source Type: research
Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography-tandem mass spectrometry
Amino Acids. 2023 Sep 10. doi: 10.1007/s00726-023-03315-z. Online ahead of print.ABSTRACTNarcolepsy is a chronic and underrecognized sleep disorder characterized by excessive daytime sleepiness and cataplexy. Furthermore, narcolepsy type 1 (NT1) has serious negative impacts on an individual's health, society, and the economy. Currently, many sleep centers lack the means to measure orexin levels in the cerebrospinal fluid. We aimed to analyze the characteristics of metabolite changes in patients with NT1, measured by ultra-performance liquid chromatography-tandem mass spectrometry. A principal component analysis (PCA), an o...
Source: Amino Acids - September 9, 2023 Category: Biochemistry Authors: Qingqing Zhan Lili Wang Nan Liu Yuqing Yuan Liying Deng Yongmin Ding Fen Wang Jian Zhou Liang Xie Source Type: research
Detection of resistance and virulence plasmids in Campylobacter coli and Campylobacter jejuni isolated from North Carolina food animal production, 2018-2019
Food Microbiol. 2023 Dec;116:104348. doi: 10.1016/j.fm.2023.104348. Epub 2023 Aug 11.ABSTRACTCampylobacter remains the leading cause of bacterial foodborne illness in the U.S. and worldwide. Campylobacter plasmids may play a significant role in antimicrobial resistance (AMR) and virulence factor distribution, and potentially drive rapid adaptation. C. coli (n = 345) and C. jejuni (n = 199) isolates collected from live cattle, swine, turkey, and chickens, poultry carcasses at production, and retail meat in N.C. were analyzed to determine plasmid prevalence, extrachromosomal virulence and AMR genes, and the phylogeny of asse...
Source: Food Microbiology - September 9, 2023 Category: Food Science Authors: Dawn M Hull Erin Harrel Lyndy Harden Siddhartha Thakur Source Type: research
A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses
This study focuses on the hemagglutinin (HA) consensus-based approach towards developing a more broadly protective swine influenza vaccine against various H3 strains circulating in domestic pig populations. By computationally analyzing >1000 swine H3 full-length HA sequences, we generated a consensus H3 and expressed it in the context of influenza A WSN/33 reverse genetics system. The derived recombinant chimeric swine influenza virus with the consensus H3 was inactivated and further evaluated as a potential universal vaccine in pigs. The consensus H3 vaccine elicited broadly active hemagglutination inhibition (HI) anti...
Source: Vaccine - September 9, 2023 Category: Allergy & Immunology Authors: Jieshi Yu Chithra Sreenivasan Zhizhang Sheng Shao-Lun Zhai Jared W Wollman Sisi Luo Chen Huang Rongyuan Gao Zhao Wang Radhey S Kaushik Jane Christopher-Hennings Eric Nelson Ben M Hause Feng Li Dan Wang Source Type: research
Evaluation of dynamics of immune responses and protective efficacy in piglets immunized with an inactivated porcine reproductive and respiratory syndrome vaccine candidate
In this study, we investigated the protective efficacy of an inactivated PRRS virus vaccine candidate and evaluated the differences in PRRSV specific anamnestic response in piglets when challenged with live PRRSV at two different intervals post-immunization. Six-week-old piglets were immunized intramuscularly with an inactivated, Montanide ISA-206 adjuvanted Indian PRRSV isolate, followed by a booster dose at 21 days post-immunization. Homologous live PRRS virus challenge was done on 60 and 180 days post-booster (dpb). We assessed humoral and cell-mediated immune responses at various intervals post-immunization and after c...
Source: Vaccine - September 9, 2023 Category: Allergy & Immunology Authors: Megha Katare Pandey Katherukamem Rajukumar Dhanapal Senthilkumar Subbiah Kombiah Fateh Singh Govindarajulu Venkatesh Manoj Kumar Sangeeta Shrivas Deepali Shrivastava Vijendra Pal Singh Aniket Sanyal Source Type: research
