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“The Graves Cannot Be Dug Fast Enough”: Excess Deaths Among US Amish and Mennonites During the 1918 Flu Pandemic
AbstractEstimating the lethal impact of a pandemic on a religious community with significant barriers to outsiders can be exceedingly difficult. Nevertheless, Stein and colleagues (2021) developed an innovative means of arriving at such an estimate for the lethal impact of COVID-19 on the Amish community in 2020 by counting user-generated death reports in the widely circulated Amish periodicalThe Budget. By comparing monthly averages of reported deaths before and during the COVID-19 pandemic, Stein and colleagues were able to arrive at a rough estimate of “excess deaths” during the first year of the pandemic. Our resea...
Source: Journal of Religion and Health - September 1, 2023 Category: Medical Ethics Source Type: research

Now experts call for more people to get a Covid booster as health bosses pull forward vaccination programme for vulnerable amid fears surrounding Pirola variant - but MPs call for calm and to 'treat it just like a seasonal flu'
It comes less than 24 hours after health officials u-turned again on the autumn Covid and flu jab drive start date in England, bringing it forwards from October to September 11.
Source: the Mail online | Health - August 31, 2023 Category: Consumer Health News Source Type: news

Now experts call for everyone to have another covid booster as health bosses pull forward vaccination programme for vulnerable amid fears Pirola variant 'could overwhelm NHS' - but MPs call for calm and to 'treat it just like a seasonal flu'
It comes less than 24 hours after health officials u-turned again on the autumn Covid and flu jab drive start date in England, bringing it forwards from October to September 11.
Source: the Mail online | Health - August 31, 2023 Category: Consumer Health News Source Type: news

Podcast: Speeding up COVID jabs, Labour's continuity plans, the GP workforce crisis and Good Medical Practice
Talking General practice discusses a last-minute U-turn on COVID and flu jabs, another controversial plan from Labour, what GPs think about the NHS workforce plan, and the GMC's update of Good Medical Practice.
Source: GP Online News - August 31, 2023 Category: Primary Care Tags: Podcast Source Type: news

Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
Curr Opin Immunol. 2023 Aug 29;84:102386. doi: 10.1016/j.coi.2023.102386. Online ahead of print.ABSTRACTThe eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs in history. This achievement can be attributed to the development of vaccines that received the public's almost unwavering acceptance of them, especially by parents who had been waiting/hoping for a medical breakthrough that would ensure that their children would not succumb to the devastating effects of infantile paralysis. Sixty years later, the worldwide population was now confronted with an equal...
Source: Current Opinion in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Charles S Pavia Maria M Plummer Source Type: research

Characterization of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the Cap protein of porcine circovirus type 2d
Comp Immunol Microbiol Infect Dis. 2023 Aug 27;101:102054. doi: 10.1016/j.cimid.2023.102054. Online ahead of print.ABSTRACTPorcine circovirus type 2 (PCV2) plays a key role in the etiology of PCV2-associated disease (PCVAD), and its predominant strain is PCV2d which is not completely controlled by most commercially available vaccines against PCV2a strains. Pseudorabies (PR) caused by pseudorabies virus (PRV) variants re-emerged in Bartha-K61 vaccine-immunized swine herds in late 2011, which brought considerable losses to the global pig husbandry. Therefore, it is significantly important to develop a safe and effective vacc...
Source: Comparative immunology, microbiology and infectious diseases. - August 31, 2023 Category: Allergy & Immunology Authors: Rui-Qin Xu Lin-Qing Wang Hui-Hua Zheng Run-Bo Tian Lan-Lan Zheng Shi-Jie Ma Hong-Ying Chen Source Type: research

The atypical antidepressant tianeptine confers neuroprotection against oxygen-glucose deprivation
In conclusion, this study highlights the comparative strength of the 5-HT independent neuroprotective effects of TIA and identifies the molecular pathways involved.PMID:37653354 | DOI:10.1007/s00406-023-01685-9
Source: European Archives of Psychiatry and Clinical Neuroscience - August 31, 2023 Category: Psychiatry Authors: Burcu Ersoy Marie-Louise Herzog Wen Pan Simone Schilling Matthias Endres Ria G öttert Golo D Kronenberg Karen Gertz Source Type: research

Randomised Controlled Trial on Prophylaxis of Mastitis-Metritis-Agalactia Syndrome in Swine using Caulophyllum Logoplex and Lachesis Logoplex
CONCLUSIONS: Prophylaxis with the homeopathic remedies Caulophyllum Logoplex and Lachesis Logoplex in the present study showed neither an improvement in MMA prevention nor an improvement in health parameters or behavioural traits in the present herd of sows.PMID:37652040 | DOI:10.1055/s-0043-1770725
Source: Homeopathy - August 31, 2023 Category: Complementary Medicine Authors: Kathrin B üttner Janna Oelkers Onno Burfeind Joachim Krieter Irena Czycholl Source Type: research

Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
Curr Opin Immunol. 2023 Aug 29;84:102386. doi: 10.1016/j.coi.2023.102386. Online ahead of print.ABSTRACTThe eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs in history. This achievement can be attributed to the development of vaccines that received the public's almost unwavering acceptance of them, especially by parents who had been waiting/hoping for a medical breakthrough that would ensure that their children would not succumb to the devastating effects of infantile paralysis. Sixty years later, the worldwide population was now confronted with an equal...
Source: Current Opinion in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Charles S Pavia Maria M Plummer Source Type: research

Characterization of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the Cap protein of porcine circovirus type 2d
Comp Immunol Microbiol Infect Dis. 2023 Aug 27;101:102054. doi: 10.1016/j.cimid.2023.102054. Online ahead of print.ABSTRACTPorcine circovirus type 2 (PCV2) plays a key role in the etiology of PCV2-associated disease (PCVAD), and its predominant strain is PCV2d which is not completely controlled by most commercially available vaccines against PCV2a strains. Pseudorabies (PR) caused by pseudorabies virus (PRV) variants re-emerged in Bartha-K61 vaccine-immunized swine herds in late 2011, which brought considerable losses to the global pig husbandry. Therefore, it is significantly important to develop a safe and effective vacc...
Source: Comparative immunology, microbiology and infectious diseases. - August 31, 2023 Category: Allergy & Immunology Authors: Rui-Qin Xu Lin-Qing Wang Hui-Hua Zheng Run-Bo Tian Lan-Lan Zheng Shi-Jie Ma Hong-Ying Chen Source Type: research

Randomised Controlled Trial on Prophylaxis of Mastitis-Metritis-Agalactia Syndrome in Swine using Caulophyllum Logoplex and Lachesis Logoplex
CONCLUSIONS: Prophylaxis with the homeopathic remedies Caulophyllum Logoplex and Lachesis Logoplex in the present study showed neither an improvement in MMA prevention nor an improvement in health parameters or behavioural traits in the present herd of sows.PMID:37652040 | DOI:10.1055/s-0043-1770725
Source: Homeopathy - August 31, 2023 Category: Complementary Medicine Authors: Kathrin B üttner Janna Oelkers Onno Burfeind Joachim Krieter Irena Czycholl Source Type: research

Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
Curr Opin Immunol. 2023 Aug 29;84:102386. doi: 10.1016/j.coi.2023.102386. Online ahead of print.ABSTRACTThe eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs in history. This achievement can be attributed to the development of vaccines that received the public's almost unwavering acceptance of them, especially by parents who had been waiting/hoping for a medical breakthrough that would ensure that their children would not succumb to the devastating effects of infantile paralysis. Sixty years later, the worldwide population was now confronted with an equal...
Source: Current Opinion in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Charles S Pavia Maria M Plummer Source Type: research

The atypical antidepressant tianeptine confers neuroprotection against oxygen-glucose deprivation
In conclusion, this study highlights the comparative strength of the 5-HT independent neuroprotective effects of TIA and identifies the molecular pathways involved.PMID:37653354 | DOI:10.1007/s00406-023-01685-9
Source: European Archives of Psychiatry and Clinical Neuroscience - August 31, 2023 Category: Psychiatry Authors: Burcu Ersoy Marie-Louise Herzog Wen Pan Simone Schilling Matthias Endres Ria G öttert Golo D Kronenberg Karen Gertz Source Type: research