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Total 44518 results found since Jan 2013.

GSE241965 Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection
Contributors : Spencer R Keilich ; Andreia N Cadar ; Darcy T Ahern ; Blake L Torrance ; Erica C Lorenzo ; Dominique E Martin ; Laura Haynes ; Jenna M BartleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOlder adults have diminished immune responses that increase susceptibility to infectious diseases, such as influenza (flu). In older adults, flu infection can lead to hospitalization, catastrophic disability, and mortality. We previously demonstrated severe and prolonged muscle degradation and atrophy in aged mice during flu infection. Here, we utilized an unbiased transcriptomic ana...
Source: GEO: Gene Expression Omnibus - September 5, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Respiratory syncytial virus burden and risk factors for severe disease in patients presenting to the emergency department with flu-like symptoms or acute respiratory failure
Predictors of Respiratory Syncytial Virus (RSV) infection and determinants of RSV unfavorable outcomes are still unclear. We assessed RSV burden and investigated the risk factors associated with RSV positive swab and RSV severe disease.
Source: Respiratory Medicine - September 5, 2023 Category: Respiratory Medicine Authors: Pierachille Santus, Dejan Radovanovic, Maria Rita Gismondo, Sara Giordana Rimoldi, Alessandra Lombardi, Fiammetta Danzo, Andrea Gori, Spinello Antinori, Giuliano Rizzardini Tags: Original Research Source Type: research

Molecules, Vol. 28, Pages 6441: Nanoparticles Carrying Conserved Regions of Influenza A Hemagglutinin, Nucleoprotein, and M2 Protein Elicit a Strong Humoral and T Cell Immune Response and Protect Animals from Infection
In this study, we obtained recombinant virus-like particles formed by an artificial self-assembling peptide (SAP) carrying two epitopes from NP, tandem copies of M2e and HA2 peptides, along with a T helper Pan DR-binding epitope (PADRE). Fusion proteins expressed in Escherichia coli self-assembled in vitro into spherical particles with a size of 15&ndash;35 nm. Immunization of mice with these particles induced strong humoral immune response against M2e and the entire virus, and lead to the formation of cytokine-secreting antigen-specific CD4+ and CD8+ effector memory T cells. Immunization provided high protection o...
Source: Molecules - September 5, 2023 Category: Chemistry Authors: Anna A. Zykova Elena A. Blokhina Liudmila A. Stepanova Marina A. Shuklina Olga O. Ozhereleva Liudmila M. Tsybalova Victor V. Kuprianov Nikolai V. Ravin Tags: Article Source Type: research

Feasibility of the glue-in-plug technique using a novel liquid embolic material in a swine mode
To evaluate the feasibility of the glue-in-plug (GIP) technique using n-butyl-2-cyanoacrylate ‒Lipiodol (NL)‒iopamidol (NLI) for short-segment embolization in swine.
Source: Journal of Vascular and Interventional Radiology : JVIR - September 5, 2023 Category: Radiology Authors: Akira Ikoma, Tetsuo Sonomura, Nobuyuki Higashino, Kodai Fukuda, Hironobu Ihira, Hiroki Furotani, Masataka Koike, Hirotatsu Sato, Shin-Ichi Murata, Hiroki Minamiguchi Tags: Laboratory Investigation Source Type: research

Viruses, Vol. 15, Pages 1874: HDAC-Specific Inhibitors Induce the Release of Porcine Epidemic Diarrhea Virus via the COPII-Coated Vesicles
In this study, we found that the histone deacetylase (HDAC)-specific inhibitors, trichostatin A (TSA) and sodium butyrate (NaB), facilitate the secretion of infectious PEDV particles without interfering with its assembly. We found that PEDV N protein and its replicative intermediate dsRNA colocalize with coat protein complex II (COPII)-coated vesicles. We also showed that the colocalization of PEDV and COPII is enhanced by the HDAC-specific inhibitors. In addition, ultrastructural analysis revealed that the HDAC-specific inhibitors promote COPII-coated vesicles carrying PEDV virions and the secretion of COPII-coated vesicl...
Source: Viruses - September 4, 2023 Category: Virology Authors: Ying Yang Huan Chen Caisheng Zhang Hyun-Jin Shin Yingjuan Qian Yong-Sam Jung Tags: Article Source Type: research

Viruses, Vol. 15, Pages 1870: Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus
Yidi Guo Classical swine fever virus (CSFV), which is a positive-sense, single-stranded RNA virus with an envelope, is a member of the Pestivirus genus in the Flaviviridae family. CSFV causes a severe and highly contagious disease in pigs and is prevalent worldwide, threatening the pig farming industry. The detailed mechanisms of the CSFV life cycle have been reported, but are still limited. Some receptors and attachment factors of CSFV, including heparan sulfate (HS), laminin receptor (LamR), complement regulatory protein (CD46), MER tyrosine kinase (MERTK), disintegrin, and metalloproteinase domain-containing prot...
Source: Viruses - September 3, 2023 Category: Virology Authors: Xin Guo Maolin Zhang Xiaomin Liu Yannan Zhang Chongyang Wang Yidi Guo Tags: Review Source Type: research

Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
This article represents a comprehensive review of the function, structure and inhibition of SARS-CoV and -CoV-2 Mpro, including structure-activity relationships, protein-inhibitor interactions and clinical trial status.PMID:37659195 | DOI:10.1016/j.ejmech.2023.115772
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Xin Li Yongcheng Song Source Type: research

Effective treatment of a broad-host-range lytic phage SapYZU15 in eliminating Staphylococcus aureus from subcutaneous infection
In this study, the antimicrobial susceptibility of 47 S. aureus isolates from three swine farms, two slaughterhouses, and four markets (Yangzhou, China) were evaluated. The biological characteristics of four lytic S. aureus phages were compared and the lytic activity of phage SapYZU15 against MDR S. aureus was assessed using milk, fresh pork and a mouse model of subcutaneous abscess. The results showed that 28 S. aureus isolates (59.6%, 28/47) exhibited multiple antibiotic resistance to at least three different classes of antibiotics. Compared to SapYZU01, SapYZU02, and SapYZU03, SapYZU15 had a shorter latent period (10 mi...
Source: Cell Research - September 2, 2023 Category: Cytology Authors: Hua Wen Wenyuan Zhou Ying Wu Yajie Li Guoqiang Zhu Zhenwen Zhang Xuewen Gu Cuimei Wang Zhenquan Yang Source Type: research

Outcome of first or second transplantation using unrelated umbilical cord blood without ATG conditioning regimen for pediatric bone marrow failure disorders
CONCLUSION: UCBT is an effective alternative treatment for bone marrow failure pediatric patients. TBI/BU + FLU + CY regimen ensure a high engraftment rate for unrelated umbilical cord blood transplantation, which overcomes the difficulty of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.PMID:37659255 | DOI:10.1016/j.bcmd.2023.102793
Source: Blood Cells, Molecules and Diseases - September 2, 2023 Category: Hematology Authors: Xia Chen Fang Liu Yuanyuan Ren Luyang Zhang Yang Wan Wenyu Yang Xiaojuan Chen Li Zhang Yao Zou Yumei Chen Xiaofan Zhu Ye Guo Source Type: research

White House seeks input on tightening rules for risky pathogen research
A panel’s recommendations earlier this year to tighten U.S. rules for funding research on dangerous pathogens sparked concerns that some of the changes would hamper routine studies important to public health. Now, the White House is looking at ways to narrow the swath of federally funded research that would undergo the heightened reviews proposed in a final report released in March by the National Science Advisory Board for Biosecurity (NSABB). A notice posted today in the Federal Register by the Office of Science and Technology Policy (OSTP) seeks comments by 16 October on a range of issues,...
Source: ScienceNOW - September 1, 2023 Category: Science Source Type: news

It ’s OK To Get Your Covid, Flu And RSV Shots At The Same Time, Experts Say
RSV vaccines were approved for the time in the U.S. and manufacturers are working on new Covid boosters to protect against the dominant strains circulating the country.
Source: Forbes.com Healthcare News - September 1, 2023 Category: Pharmaceuticals Authors: Arianna Johnson, Forbes Staff Tags: Innovation /innovation Healthcare /healthcare Breaking breaking-news Trending Explainer Trending-Explainer topline Source Type: news

It ’s Okay To Get Your Covid, Flu And RSV Shots At The Same Time, Experts Say
RSV vaccines were approved for the first time in the U.S., and manufacturers are working on new Covid boosters to protect against the dominant strains circulating the country.
Source: Forbes.com Healthcare News - September 1, 2023 Category: Pharmaceuticals Authors: Arianna Johnson, Forbes Staff Tags: Innovation /innovation Healthcare /healthcare Breaking breaking-news Trending Explainer Trending-Explainer topline Source Type: news

Movers and Shakers September 2023
Dr. Mgbokikwe Nkemdilim Mgbojikwe, MD, has joined Fox Chase Cancer Center, Philadelphia, as associate chief medical officer; she will also serve as an associate professor and hospitalist in the department of medicine. Prior to joining Fox Chase Cancer Center, Dr. Mgbojikwe was clinical director of the division of hospital medicine, medical director for four med-surg inpatient units, and medical co-director of the medicine progressive care unit at Johns Hopkins Hospital, director for acute virtual care strategy at Johns Hopkins Health System, and assistant professor of medicine at Johns Hopkins University School of Medicin...
Source: The Hospitalist - September 1, 2023 Category: Hospital Management Authors: Lisa Casinger Tags: Career People in HM Source Type: research

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