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Two Case Reports of Chronic Inflammatory Demyelinating Polyneuropathy After COVID-19 Vaccination
We describe two patients who were diagnosed with CIDP after COVID-19 vaccination. A 72-year-old man presented with a progressive tingling sensation and weakness below both knees for two weeks. He had been vaccinated against COVID-19 (mRNA-1273 vaccine) a month before the appearance of symptoms. Demyelinating polyneuropathy was observed in the nerve conduction studies (NCS). Intravenous immunoglobulin (IVIg) was administered under the diagnosis of Guillain-Barré syndrome (GBS), and his symptoms were improved. However, his symptoms relapsed at 10 weeks from the onset. Oral prednisolone, azathioprine, and IVIg were administe...
Source: Journal of Korean Medical Science - February 28, 2023 Category: Biomedical Science Authors: Sooyoung Kim Eun Kyoung Lee Eunhee Sohn Source Type: research
Amyloid-like IgM Deposition Neuropathy with Multiple Mononeuropathies and Generalized Neuropathy
Immunoglobulin M (IgM) monoclonal gammopathy is the most common subtype of paraproteinemia to cause neuropathy. The well-known characteristics of many IgM associated neuropathies are distal acquired demyelinating symmetric neuropathy (DADS) presenting as painless sensory ataxia and to a lesser degree, chronic inflammatory demyelinating polyneuropathy (CIDP) phenotype. Other possible manifestations are multiple mononeuropathy due to IgM related microvasculitis with mixed cryoglobulinemia, light chain amyloidosis, neurolymphomatosis from an underlying hematologic malignancy and rarely, IgM deposition neuropathy [1 –3].
Source: Neuromuscular Disorders - February 23, 2023 Category: Neurology Authors: Pannathat Soontrapa, Christopher J. Klein, P. James B. Dyck, Sarah E. Berini, Ellen D. McPhail, Moritz Binder, Pitcha Chompoopong, JaNean Engelstad, Kamal Shouman Tags: Case report Source Type: research
Siponimod ameliorates experimental autoimmune neuritis
Guillain –Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are human autoimmune peripheral neuropathy. Besides humoral immunity, cellular immunity is also believed to contribute...
Source: Journal of Neuroinflammation - February 14, 2023 Category: Neurology Authors: Takafumi Uchi, Shingo Konno, Hideo Kihara and Toshiki Fujioka Tags: Research Source Type: research
Electronic Monitoring of Disease Activity in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Condition: CIDP Intervention: Device: Smartwatch (Withings Scanwatch) Sponsor: Heinrich-Heine University, Duesseldorf Recruiting
Source: ClinicalTrials.gov - February 13, 2023 Category: Research Source Type: clinical trials
Intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): mechanisms of action and clinical and genetic considerations
Expert Rev Neurother. 2023 Jan 16. doi: 10.1080/14737175.2022.2169134. Online ahead of print.ABSTRACTINTRODUCTION: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune peripheral nerve disorder that is characterized by subacute onset, progressive or relapsing weakness, and sensory deficits. Proven treatments include intravenous immunoglobulin (IVIg), Corticosteroids, and plasma exchange. This review focuses on the mechanisms of action, pharmacodynamics, genetic variations, and disease characteristics that can affect the efficacy of IVIg.AREAS COVERED: The proposed mechanisms of action of IVIg t...
Source: Expert Review of Neurotherapeutics - January 16, 2023 Category: Neurology Authors: Marinos C Dalakas Norman Latov Krista Kuitwaard Source Type: research
