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Total 3270 results found since Jan 2013.

Chronic inflammatory neuropathies and their impact on activities and participation
CONCLUSION AND KEY FINDINGS: Activity limitations and restrictions in participation are common in CIDP patients and to a lesser extent in MMN patients. Fatigue, pain and resilience independently contributed to perceived limitations in CIDP patients. Referral to rehabilitation physician is warranted, to address these limitations appropriately.PMID:37038272 | DOI:10.1111/ene.15815
Source: Pain Physician - April 11, 2023 Category: Anesthesiology Authors: H A Wonink W J Kruithof H S Goedee A Beelen Source Type: research

Anti-Lactosylceramide antibody positive combined central peripheral demyelination emerging from long-standing juvenile-onset chronic inflammatory polyradiculoneuropathy; a report of two cases
Anti-Lactosylceramide (LacCer) antibodies are associated with neurological inflammation involving both the peripheral and central nervous system (PNS, CNS respectively), however, the documented number of cases is small. Uncertainty remains whether its positivity can identify a unique clinical entity. Here, we describe two anti-LacCer antibody positive cases, both with long histories (> 30  years) of teenage-diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). CNS lesions including the medulla oblongata were observed for the first time in adulthood.
Source: Journal of Neuroimmunology - April 10, 2023 Category: Allergy & Immunology Authors: Naoki Takegami, Kaori Sakuishi, Nanaka Yamaguchi-Takegami, Shuhei Egashira, Shogo Komaki, Tatsuro Mutoh, Tatsushi Toda Tags: Short Communication Source Type: research

Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review
In conclusion, the case and literature demonstrated that TCM treatment might be a more effective, low-cost, and safe option for treating CIDP. Although these preliminary findings are promising, a larger sample size and higher-quality randomized clinical trials are urgently required to confirm our findings.
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research

Effect of strength training on functional outcomes and strength in patients with polyneuropathy: A scoping review
Discussion: In this scoping review we summarized research on strength training and outcomes evaluated in interventions in patients with PNP. Eight studies were included, they indicated that strength training may be beneficial for patients with PNP. However, due to low methodological strength of most studies a recommendation for patients with PNP cannot be made. Thus, the low number of studies with relatively low quality, where various functional outcomes were used, underscores the importance of future studies to evaluate the effect of strength training on relevant functional outcomes and strength in patients with PNP.
Source: Frontiers in Physiology - April 6, 2023 Category: Physiology Source Type: research

Current clinical management of CIDP with immunoglobulins in France: An expert opinion
Rev Neurol (Paris). 2023 Apr 3:S0035-3787(23)00892-5. doi: 10.1016/j.neurol.2023.03.010. Online ahead of print.ABSTRACTTreatment strategies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) must be adapted on a case-to-case basis. Validated and reproducible tools for monitoring treatment response are required at diagnosis, when initiating treatment and throughout follow-up. A task force of French neurologists, experts in neuromuscular disease reference centers, was assembled to provide expert advice on the management of typical CIDP with intravenous immunoglobulins (Ig), and to harmonize treatment practic...
Source: Revue Neurologique - April 5, 2023 Category: Neurology Authors: P Cintas F Bouhour C Cauquil M Masingue C Tard S Sacconi E Delmont A Choumert J-B Chanson M Michaud G Sol é J Cassereau J-B Noury G Nicolas R Bellance Y P éréon J-P Camdessanch é L Magy S Attarian French Neuromuscular diseases network (Filnemus) Source Type: research

Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients
Conclusions: Effect sizes and mean differences were rather small so that a reliable diagnosis cannot be performed based on the vagus nerve measurement of a single person alone. Vagus nerve CSA seems not suitable as an indicator of autonomic dysfunction or cardiovascular risk in diabetic patients.PMID:36984526 | DOI:10.3390/medicina59030525
Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Bianka Heiling Adriana Karl Nadin Fedtke Nicolle M üller Christof Kloos Alexander Grimm Hubertus Axer Source Type: research

CIDP: Analysis of Immunomarkers During COVID-19 mRNA-Vaccination and IVIg-Immunomodulation: An Exploratory Study
This study was registered in the German clinical trial register (DRKS00025759).Graphical AbstractOverview over the study design. Blood samples of CIDP patients on recurrent IVIg treatment and vaccination with a COVID-19 mRNA vaccine were obtained at four timepoints for cytokine ELISA and flow cytometry, to assess key cytokines and cellular immunomarkers for disease activity and IVIg-immunomodulation in CIDP.
Source: Journal of NeuroImmune Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research

Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF ‐κB signaling
ConclusionOur data showed that fingolimod could improve the disease course, alleviate the decrease in inflammation, and reduce proinflammatory cytokines through the Akt/mTOR/NF- κB axis in c-EAN rats, which could be beneficial for the development of CIDP-related research.
Source: Brain and Behavior - March 14, 2023 Category: Neurology Authors: Yuan Feng, Fang Feng, Shuyi Pan, Jiewen Zhang, Wei Li Tags: ORIGINAL ARTICLE Source Type: research

Recurrent Sensory-Motor Neuropathy Mimicking CIDP as Predominant Presentation of PDH Deficiency
Conclusion We summarize the clinical and genetic characteristics of one patient with PDH deficiency presenting isolated peripheral nervous system involvement. This study highlights that the diagnosis of PDH deficiency should be considered in children with unexplained peripheral neuropathy, even with features suggestive of acquired forms, especially in case of early onset and limited response to treatment. A simple analysis of lactic acid could help to target the diagnosis.In addition, we suggest that the residue Arg88 is the most frequently involved in this specific phenotype of PDH deficiency. [...] Georg Thieme Verlag ...
Source: Neuropediatrics - March 7, 2023 Category: Neurology Authors: Croci, Carolina Cataldi, Matteo Baratto, Serena Bruno, Claudio Trucco, Federica Doccini, Stefano Romano, Alessandro Nesti, Claudia Santorelli, Filippo Maria Fiorillo, Chiara Tags: Short Communications Source Type: research

Chronic inflammatory demyelinating polyradiculoneuropathy associated with Sj ögren`s syndrome in a child
CONCLUSIONS: To our knowledge, our case is the first pediatric case with the coexistence of Sjögren`s syndrome and CIDP. Therefore, we suggest investigating children with CIDP in terms of underlying autoimmune diseases such as Sjögren`s syndrome.PMID:36866997 | DOI:10.24953/turkjped.2022.460
Source: The Turkish Journal of Pediatrics - March 3, 2023 Category: Pediatrics Authors: Nur şah Yeniay Süt Ay şe Tuğba Kartal Şeyma Ertem Fatma Ayd ın Mira ç Yıldırım Ömer Bektaş Zeynep Birsin Özçakar Serap Teber Source Type: research