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Intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): mechanisms of action and clinical and genetic considerations
Expert Rev Neurother. 2023 Jan 16. doi: 10.1080/14737175.2022.2169134. Online ahead of print.ABSTRACTINTRODUCTION: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune peripheral nerve disorder that is characterized by subacute onset, progressive or relapsing weakness, and sensory deficits. Proven treatments include intravenous immunoglobulin (IVIg), Corticosteroids, and plasma exchange. This review focuses on the mechanisms of action, pharmacodynamics, genetic variations, and disease characteristics that can affect the efficacy of IVIg.AREAS COVERED: The proposed mechanisms of action of IVIg t...
Source: Expert Review of Neurotherapeutics - January 16, 2023 Category: Neurology Authors: Marinos C Dalakas Norman Latov Krista Kuitwaard Source Type: research
