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Total 478012 results found since Jan 2013.
mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine
Publication date: 30 August 2018Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86Author(s): Shin-Han Huang, Wan-Rong Wu, Li-Ming Lee, Pei-Rong Huang, Jin-Chung ChenAbstractChronic psychostimulant treatment in rodents readily produces behavioral sensitization, which reflects altered brain function in response to repeated drug exposure. Numerous morphological and biochemical investigations implicate altered neural plasticity in striatal medium spiny neurons (MSNs) as an essential component in behavioral sensitization. The mammalian target of the rapamycin (mTOR) signaling pathway, a key regula...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 5, 2018 Category: Psychiatry Source Type: research
Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders
Publication date: 30 August 2018Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86Author(s): Asem Alageel, Julia Tomasi, Claudia Tersigni, Elisa Brietzke, Hannah Zuckerman, Mehala Subramaniapillai, Yena Lee, Michelle Iacobucci, Joshua D. Rosenblat, Rodrigo B. Mansur, Roger S. McIntyreAbstractSirtuins are NAD+-dependent histone deacetylases that play essential roles in cell survival, energy metabolism, inflammation, and aging; therefore, sirtuins are potential therapeutic targets in the treatment of type 2 diabetes, cancer, inflammatory and metabolic disorders, and neurodegenerative diseases.A...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research
mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine
Publication date: 30 August 2018Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86Author(s): Shin-Han Huang, Wan-Rong Wu, Li-Ming Lee, Pei-Rong Huang, Jin-Chung ChenAbstractChronic psychostimulant treatment in rodents readily produces behavioral sensitization, which reflects altered brain function in response to repeated drug exposure. Numerous morphological and biochemical investigations implicate altered neural plasticity in striatal medium spiny neurons (MSNs) as an essential component in behavioral sensitization. The mammalian target of the rapamycin (mTOR) signaling pathway, a key regula...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research
Zebrafish models of diabetes-related CNS pathogenesis
Publication date: Available online 23 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Anton M. Lakstygal, Murilo S. de Abreu, Dmitry Lifanov, Edina A. Wappler-Guzetta, Nazar Serikuly, Erik T. Alpsychov, DongMei Wang, MengYao Wang, ZhiChong Tang, NiDong Yan, Konstantin A. Demin, Andrey D. Volgin, Tamara G. Amstislavskaya, JiaJia Wang, Cai Song, Polina Alekseeva, Allan V. KalueffAbstractDiabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression and Alzheime...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 24, 2018 Category: Psychiatry Source Type: research
Mitochondrial function and abnormalities implicated in the pathogenesis of ASD
Publication date: Available online 29 December 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Frank J. CastoraAbstractMitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In addition to its role in energy production, the mitochondrion also plays a major role in carbohydrate, fatty acid, amino acid and nucleotide metabolism, programmed cell death (apoptosis), generation of and protection against reactive oxygen species (ROS), immune response, regulation of intracellular calcium ion levels and even maintenance of gut microbiota. With its essential role in ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 30, 2018 Category: Psychiatry Source Type: research
Whole-brain functional connectivity during script-driven aggression in borderline personality disorder
ConclusionsWe identified a large network showing a significantly stronger increase in connectivity from baseline to the aggression phase in female patients with BPD compared to healthy women. The regions constituting this network belong to four previously described functional networks: The frontoparietal cognitive control network, the extended default mode network, the visual system, and the motor system. This stronger increase in connectivity between regions of different functional brain systems associated with cognitive control of behavior, socio-affective and self-referential thinking, as well as salience processing and...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 17, 2019 Category: Psychiatry Source Type: research
The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry
Publication date: Available online 3 May 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Bruna S. da Silva, Renata B. Cupertino, Jaqueline B. Schuch, Djenifer B. Kappel, Breno Sanvicente-Vieira, Cibele E. Bandeira, Lisia von Diemen, Felix H.P. Kessler, Eugenio H. Grevet, Rodrigo Grassi-Oliveira, Claiton H.D. Bau, Diego L. RovarisAbstractSynaptotagmin-1 is an essential regulator of synaptic vesicle exocytosis, and its encoding gene (SYT1) is a genome and transcriptome-wide association hit in cognitive performance, personality and cocaine use disorder (CUD) studies. Additionally, in candi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 4, 2019 Category: Psychiatry Source Type: research
Supporting microglial niches for therapeutic benefit in psychiatric disorders
Publication date: Available online 9 May 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Churchward, E.R. Michaud, K.G. ToddAbstractInflammation is an essential tissue response to injury, stress, or infection resulting in debris and/or pathogen clearance intended to promote healing and recovery. Due to the status as an immune ‘privileged’ tissue, microglia serve as endogenous regulators of inflammation in the central nervous system, but maintain communication with peripheral immune system to enable recruitment of peripheral immune cells in case of injury or infection. While microgli...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 10, 2019 Category: Psychiatry Source Type: research
Dysregulation in IL-6 receptors is associated with upregulated IL-17A related signaling in CD4+ T cells of children with autism
Publication date: Available online 23 October 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ahmed Nadeem, Sheikh F. Ahmad, Sabry M. Attia, Laila Y. AL-Ayadhi, Naif O. Al-Harbi, Saleh A. BakheetAbstractAutism spectrum disorder (ASD) is a heterogeneous syndrome characterized by dysregulations in speech and social interactions as well as repetitive and stereotypical behavioral patterns in which immune system plays a significant role. IL-6, an essential cytokine for polarization of Th0 cells into Th17 cells has been demonstrated to be crucial in the etiology of ASD in past studies both in...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 25, 2019 Category: Psychiatry Source Type: research
Hormonal responses in gambling versus alcohol abuse: A review of human studies
Publication date: Available online 28 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yansong Li, Nicolas Ramoz, Edmund Derrington, Jean-Claude DreherAbstractThe endocrine system plays an essential role in communication between various organs of the body to maintain homeostasis. Both substance use disorders (SUDs) and non-substance abuse disrupt this system and lead to hormonal dysregulations. Here, we focus on the comparison between the function of the endocrine system in gambling disorders and alcohol addiction to understand the commonalities and differences in their neurobiol...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research
Anomalous intrinsic connectivity within and between visual and auditory networks in major depressive disorder
ConclusionsOverall, our results demonstrated that abnormalities of FC in perception systems including intrinsic visual and auditory networks may explain neurobiological mechanisms underlying MDD and could serve as a potential effective biomarker.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 16, 2020 Category: Psychiatry Source Type: research
Recollecting Hanns Hippius: a stimulating pioneer of psychopharmacology and neuroscience
Int J Psychiatry Clin Pract. 2023 Jun 23:1-8. doi: 10.1080/13651501.2023.2222768. Online ahead of print.ABSTRACTHanns Hippius (1925-2021) can be seen as a stimulating pioneer of Psychopharmacology and of Neuroscience. He was very influential in this area not only in Germany, but also on an international level. With reference to clinical psychopharmacology especially his activities for the development of Clozapine are of greatest importance. When he became Chairman of the Psychiatric Department of the Ludwig-Maximilians-University Munich (1971-1994), he established all necessary facilities for research in Psychopharmacology...
Source: International Journal of Psychiatry in Clinical Practice - June 23, 2023 Category: Psychiatry Authors: Hans-J ürgen Möller Source Type: research
