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Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research
Nickel Allergy: No Device Too Small!
Source: European Journal of Vascular and Endovascular Surgery - September 13, 2023 Category: Surgery Authors: Gerri Lenth, Joel Crawford Tags: Coup D ’Oeil Source Type: research
Clinical Medicine and Climate Change
The health care system contributes substantially to global greenhouse gas emissions, a driver of climate change. At the same time, climate change has caused disruptions in health care delivery. In this article, the authors describe both how the health care industry contributes to climate change and how climate change affects patient care. The authors also provide clinical recommendations for health care practitioners to counsel patients on health effects of climate change and underscore the need for developing the workforce needed to respond to unique health care delivery challenges resulting from climate-related factors.
Source: Immunology and Allergy Clinics of North America - September 13, 2023 Category: Allergy & Immunology Authors: Pablo E. Morej ón-Jaramillo, Nicholas J. Nassikas, Mary B. Rice Source Type: research
Mental health problems associated with idiopathic anaphylaxis
Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more lik...
Source: Allergy, Asthma and Clinical Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Logan S Gardner, Zihao Tan, David Brown, David Gillis, James G. Scott and Roger Prentice Tags: Research Source Type: research
Gut microbiome is associated with asthma and race in children with food allergy.
Source: Journal of Allergy and Clinical Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Mahboobeh Mahdavinia, John P. Fyolek, Jialing Jiang, Neil Thivalapill, Lucy A. Bilaver, Christopher Warren, Susan Fox, Sai R. Nimmagadda, Pamela J. Newmark, Hemant Sharma, Amal Assa ’ad, Patrick C. Seed, Ruchi S. Gupta Source Type: research
FDA Panel Deems Phenylephrine Ineffective FDA Panel Deems Phenylephrine Ineffective
The ingredient found in Sudafed PE and Vicks Sinex is no better than a placebo.Medscape Medical News
Source: Medscape Allergy Headlines - September 12, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news
FDA Panel Says Popular OTC Cold, Allergy Medicine Might Be Useless - Stocks To Watch
According to FDA panel experts who reviewed the latest research on the long-questioned phenylephrine, a drug ingredient used in several leading decongestants used by millions of Americans looking for relief from a stuffy nose, is likely no better than a dummy pill. "We believe that these new…#fda #benadryl #mucinex #tylenol #pse #johnsonjohnson #jnj #kenvueinckvue #bayerag #gskplc
Source: Reuters: Health - September 12, 2023 Category: Consumer Health News Source Type: news
Smart Inhaler for Asthma Misses the Mark for Boosting Adherence to Meds
(MedPage Today) -- MILAN -- An electronic monitoring device (EMD) increased adherence to asthma medication in the short-term but still left patients needing more assistance in the long run, a cluster-randomized trial found.
In adult primary...
Source: MedPage Today Allergy - September 12, 2023 Category: Allergy & Immunology Source Type: news
ERS 2023 – Navigating Chronic Cough in Primary Care ERS 2023 – Navigating Chronic Cough in Primary Care
" When it comes to chronic cough, general practitioners often feel lost, " said an expert at the European Respiratory Society Congress held in Milan, Italy.Medscape Medical News
Source: Medscape Allergy Headlines - September 12, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care Source Type: news
Eustachian tube dysfunction symptoms after endonasal skull base surgery
Key points
ETD symptoms are present in 16% patients with underlying skull base pathology.
Preoperative ETD symptoms improve following surgical treatment of skull base pathology.
ETD symptoms may worsen in patients with central, posterior, or malignant skull base pathology.
Source: International Forum of Allergy and Rhinology - September 12, 2023 Category: Allergy & Immunology Authors: David Grimm,
Rachel Daum,
Bruna R. Castro Silva,
Christine K. Lee,
Juan C. Fernandez ‐Miranda,
Jayakar V. Nayak,
Zara M. Patel,
Peter H. Hwang,
Michael T. Chang Tags: RESEARCH NOTE Source Type: research
Human PLCG2 Haploinsufficiency Results in a Novel NK Cell Immunodeficiency
Dominant-negative and gain-of-function variants in PLCG2 have been previously reported to cause cold urticaria, antibody deficiency, and autoinflammation. PLCG2 haploinsufficiency is a distinct and novel immunodeficiency leading to NK cell dysfunction and is associated with severe and/or recurrent herpesvirus infections.
Source: Journal of Allergy and Clinical Immunology - September 12, 2023 Category: Allergy & Immunology Authors: Joshua B. Alinger, Emily M. Mace, Justin.R. Porter, Annelise Y. Mah-Som, Allyssa L. Daugherty, Stephanie Li, Allison A. Throm, Jeanette T. Pingel, Nermina Saucier, Albert Yao, Ivan K. Chinn, James R. Lupski, Mohammad Ehlayel, Michael Keller, Greg R. Bowma Source Type: research
Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
ConclusionsThe integrated analysis of a large number of patients detected no new safety signals with long-term CT-P13 treatment. Efficacy in rheumatoid arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis cases was confirmed in biologic-naïve patients and switched patients from the originator infliximab or other biologics.
Source: Drug Safety - September 12, 2023 Category: Drugs & Pharmacology Source Type: research
Comparison of Pneumotachometer and Portable Digital Turbine Spirometry for Field-Based Assessment: An Air Quality, Environment, and Respiratory Outcomes in Bronchopulmonary Dysplasia Study
Pediatric Allergy, Immunology, and Pulmonology,Volume 36, Issue 3, Page 115-118, September 2023.
Source: Pediatric, Allergy, Immunology, and Pulmonology - September 12, 2023 Category: Respiratory Medicine Authors: Lana Mukharesh Morgan Ryan Lystra P. Hayden Suzanne E. Dahlberg Jonathan M. Gaffin Source Type: research
Avery's Diseases of the Newborn and Avery's Neonatology Board Review: Certification and Clinical Refresher
Pediatric Allergy, Immunology, and Pulmonology,Volume 36, Issue 3, Page 125-125, September 2023.
Source: Pediatric, Allergy, Immunology, and Pulmonology - September 12, 2023 Category: Respiratory Medicine Source Type: research
Multi-population genome-wide association meta-analysis in pediatric steroid-sensitive nephrotic syndrome
Steroid-sensitive nephrotic syndrome (SSNS) is the most common glomerular disease in children. The exact mechanisms underlying pediatric SSNS (pSSNS) remain elusive and may be heterogeneous. Nevertheless, numerous observations implicate immune dysregulation, including the triggering of flares by allergy or infections, the response to steroids/immunosuppressants, the immediate post-transplant recurrence in some cases, the unique description of remission of post-transplant nephrotic syndrome (NS) after kidney graft explantation followed by retransplantation to a non-nephrotic recipient, and abnormalities in T and B lymphocyte function.
Source: Kidney International - September 12, 2023 Category: Urology & Nephrology Authors: Olivia Boyer, Guillaume Dorval Tags: nephrology digest Source Type: research
