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Kestose Increases the Relative Abundance of < em > Faecalibacterium < /em > spp. and Nominally Increases Cow Milk Tolerant Dose in Children with Cow's Milk Allergy - Preliminary Results
Pol J Microbiol. 2023 Sep 20;72(3):299-306. doi: 10.33073/pjm-2023-030. eCollection 2023 Sep 1.ABSTRACTA single-arm study was conducted with 10 children aged 2-12 years with severe cow's milk allergy (CMA) requiring complete allergen elimination. Subjects were administered kestose, a prebiotic, at 1 or 2 g/day for 12 weeks. Results of a subsequent oral food challenge (OFC) showed a statistically significant increase in the total dose of cow's milk ingestion (1.6 ml vs. 2.7 ml, p = 0.041). However, the overall evaluation of the OFC results, TS/Pro (total score of Anaphylaxis Scoring Aichi (ASCA)/cumulative dose of protein),...
Source: Polish Journal of Microbiology - September 19, 2023 Category: Microbiology Authors: Shohei Kubota Shiro Sugiura Mayuko Takahashi Yoshihiro Kadota Yoshihiro Takasato Teruaki Matsui Katsumasa Kitamura Takumi Tochio Komei Ito Source Type: research
Chronic Spontaneous Urticaria Following mRNA COVID-19 Booster Vaccination at a Military Academy
We present a retrospective case series of CSU following Moderna COVID-19 booster vaccinations at the US Naval Academy (USNA). Demographics, clinical features, and impact on readiness were evaluated. Forty-nine students from the USNA were evaluated for urticaria after their third COVID-19 booster vaccination. Seventeen individuals were diagnosed with CSU. The median age was 20 years and predominantly male; the median time interval between vaccination and the onset of urticaria was 11 days. Out of 13 referred to Allergy, 7 patients had CU index performed and 2 were positive. Four patients received a second booster vaccinatio...
Source: Military Medicine - September 19, 2023 Category: International Medicine & Public Health Authors: Mechelle A Miller Emily R Raffetto Rachel U Lee Source Type: research
Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions
Conclusion: This study demonstrated the candidate HLA alleles that are significantly associated with several phenotypes of beta-lactam antibiotics-related SCARs. However, whether the HLA alleles observed in this study can be used as valid genetic markers for SCARs related to beta-lactam antibiotics needs to be further explored in other ethnicities and larger cohort studies.
Source: Frontiers in Pharmacology - September 19, 2023 Category: Drugs & Pharmacology Source Type: research
Doctors admit they can't tell Covid apart from allergies or the common cold anymore - highlighting how mild virus has become
Patients with the virus are now most likely to suffer from a sore throat, sneezing or congestion - similar to those with RSV , asthma or a pollen allergy.
Source: the Mail online | Health - September 18, 2023 Category: Consumer Health News Source Type: news
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Tackling food allergens-The role of food processing on proteins' allergenicity
Adv Food Nutr Res. 2023;106:317-351. doi: 10.1016/bs.afnr.2023.04.001. Epub 2023 Sep 9.ABSTRACTThis chapter examines how innovative and emerging food processing technologies, such as those that use heat, electricity, electromagnetic waves, and pressure, can modify protein denaturation, aggregation, and intermolecular interactions pathways, which can result in varying immunoreactive responses. It emphasizes the need to understand how these processing methods affect the protein epitopes recognized by antibodies and their respective priming pathways, especially during the sensitization stage that precedes an allergic response...
Source: Advances in Food and Nutrition Research - September 18, 2023 Category: Nutrition Authors: Ricardo N Pereira Rui M Rodrigues Daniel A Madalena Ant ónio Vicente Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Tackling food allergens-The role of food processing on proteins' allergenicity
Adv Food Nutr Res. 2023;106:317-351. doi: 10.1016/bs.afnr.2023.04.001. Epub 2023 Sep 9.ABSTRACTThis chapter examines how innovative and emerging food processing technologies, such as those that use heat, electricity, electromagnetic waves, and pressure, can modify protein denaturation, aggregation, and intermolecular interactions pathways, which can result in varying immunoreactive responses. It emphasizes the need to understand how these processing methods affect the protein epitopes recognized by antibodies and their respective priming pathways, especially during the sensitization stage that precedes an allergic response...
Source: Advances in Food and Nutrition Research - September 18, 2023 Category: Nutrition Authors: Ricardo N Pereira Rui M Rodrigues Daniel A Madalena Ant ónio Vicente Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Analysis of common allergens affecting patients with allergic rhinitis
This study aimed to identify the common allergens affecting patients with AR. A total of 52 patients with AR were identified for this study. AR was diagnosed based on the presenting symptoms and measurement of IgE levels and absolute eosinophil counts. Skin prick tests (SPT) were performed to identify the allergen sensitivity of the patients. Patient history, family history, and a detailed account of the symptoms were recorded. Finally, correlation between family history and allergy severity was statistically evaluated. All patients presented symptoms of rhinitis with sinusitis and 61.5% of these were mild or moderate alle...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Kumari Ranjana Maheshwari M Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Tackling food allergens-The role of food processing on proteins' allergenicity
Adv Food Nutr Res. 2023;106:317-351. doi: 10.1016/bs.afnr.2023.04.001. Epub 2023 Sep 9.ABSTRACTThis chapter examines how innovative and emerging food processing technologies, such as those that use heat, electricity, electromagnetic waves, and pressure, can modify protein denaturation, aggregation, and intermolecular interactions pathways, which can result in varying immunoreactive responses. It emphasizes the need to understand how these processing methods affect the protein epitopes recognized by antibodies and their respective priming pathways, especially during the sensitization stage that precedes an allergic response...
Source: Advances in Food and Nutrition Research - September 18, 2023 Category: Nutrition Authors: Ricardo N Pereira Rui M Rodrigues Daniel A Madalena Ant ónio Vicente Source Type: research
Analysis of common allergens affecting patients with allergic rhinitis
This study aimed to identify the common allergens affecting patients with AR. A total of 52 patients with AR were identified for this study. AR was diagnosed based on the presenting symptoms and measurement of IgE levels and absolute eosinophil counts. Skin prick tests (SPT) were performed to identify the allergen sensitivity of the patients. Patient history, family history, and a detailed account of the symptoms were recorded. Finally, correlation between family history and allergy severity was statistically evaluated. All patients presented symptoms of rhinitis with sinusitis and 61.5% of these were mild or moderate alle...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Kumari Ranjana Maheshwari M Source Type: research
