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EpiPen Nasal Spray Suffers Setback as FDA Seeks Fresh Study EpiPen Nasal Spray Suffers Setback as FDA Seeks Fresh Study
The regulator has declined to approve a nasal spray that would have been the first needle-free emergency treatment for allergic reactions.Reuters Health Information
Source: Medscape Allergy Headlines - September 20, 2023 Category: Allergy & Immunology Tags: Pediatrics News Source Type: news
Real-world experience of hereditary angioedema (HAE) in Mexico: A mixed-methods approach to describe epidemiology, diagnosis, and treatment patterns
CONCLUSIONS: Despite efforts to make HAE visible, according to this study, cases recognized and treated in the NHS represent only 16.6% of the estimated prevalence.PMID:37727628 | PMC:PMC10506135 | DOI:10.1016/j.waojou.2023.100812
Source: Pain Physician - September 20, 2023 Category: Anesthesiology Authors: Sandra Nieto Ileana Madrigal Francisco Contreras Mar ía Eugenia Vargas Source Type: research
Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity
In this study, we report that dopamine receptor 1 (DRD1) restrains ILC2 activity in the TME. DRD1 deficiency promotes ILC2 activation, which irritates eosinophil recruitment and cytotoxic CD8+ T cell expansion during ongoing malignancy. Consequently, DRD1-deficient mice exhibit delayed tumor growth and reduced tumor progression. Furthermore, fenoldopam, a selective DRD1 agonist, restrains the ILC2 response in the TME and aggravates tumor burden in mice. Taken together, our data elaborate that the DRD1 signal acts as an excitatory rheostat in regulating ILC2-dependent antitumor immunity.PMID:37728417 | DOI:10.4049/jimmunol.2300220
Source: Journal of Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Xiangyang Wang Xiangyu Chen Jierong Chen Chunhui Liao Xiaofan Yang Jiasheng Zhou Shanshan Liu Shusen Ye Yuhao Zheng Linzi Huang Jiacong Zhao Lilin Ye Bihui Huang Yingjiao Cao Source Type: research
Two cases of allergy with mung bean sprouts
Arerugi. 2023;72(8):1046-1050. doi: 10.15036/arerugi.72.1046.ABSTRACTPatient 1 was a female patient in her teens who presented with swelling of the lips and oral discomfort after consuming mung bean sprouts. She had a history of this reaction since the age of 6 years and showed positive on a prick-to-prick test for mung bean sprouts. Patient 2 was a male patient in his twenties who also showed positive for mung bean sprouts as well as soybean sprout. Both patients were positive for IgE specific to birch, Gly m4, and Bet v1.Mung beans belong to the PR-10 family because they contain the allergenic component, Vig r1. A cross ...
Source: Allergology International - September 20, 2023 Category: Allergy & Immunology Authors: Tomoko Kobayashi Tomonobu Ito Harutaka Seshimo Chizu Egusa Kazutoshi Harada Yukari Okubo Tomoyuki Niitsuma Source Type: research
Phenotypic changes in mast cells during allergy immunotherapy
Arerugi. 2023;72(8):1026-1031. doi: 10.15036/arerugi.72.1026.NO ABSTRACTPMID:37730345 | DOI:10.15036/arerugi.72.1026
Source: Allergology International - September 20, 2023 Category: Allergy & Immunology Authors: Haruki Sasa Hitoshi Ogata Yosuke Kurashima Source Type: research
Two cases of allergy with mung bean sprouts
Arerugi. 2023;72(8):1046-1050. doi: 10.15036/arerugi.72.1046.ABSTRACTPatient 1 was a female patient in her teens who presented with swelling of the lips and oral discomfort after consuming mung bean sprouts. She had a history of this reaction since the age of 6 years and showed positive on a prick-to-prick test for mung bean sprouts. Patient 2 was a male patient in his twenties who also showed positive for mung bean sprouts as well as soybean sprout. Both patients were positive for IgE specific to birch, Gly m4, and Bet v1.Mung beans belong to the PR-10 family because they contain the allergenic component, Vig r1. A cross ...
Source: Arerugi - September 20, 2023 Category: Allergy & Immunology Authors: Tomoko Kobayashi Tomonobu Ito Harutaka Seshimo Chizu Egusa Kazutoshi Harada Yukari Okubo Tomoyuki Niitsuma Source Type: research
Phenotypic changes in mast cells during allergy immunotherapy
Arerugi. 2023;72(8):1026-1031. doi: 10.15036/arerugi.72.1026.NO ABSTRACTPMID:37730345 | DOI:10.15036/arerugi.72.1026
Source: Arerugi - September 20, 2023 Category: Allergy & Immunology Authors: Haruki Sasa Hitoshi Ogata Yosuke Kurashima Source Type: research
Two cases of allergy with mung bean sprouts
Arerugi. 2023;72(8):1046-1050. doi: 10.15036/arerugi.72.1046.ABSTRACTPatient 1 was a female patient in her teens who presented with swelling of the lips and oral discomfort after consuming mung bean sprouts. She had a history of this reaction since the age of 6 years and showed positive on a prick-to-prick test for mung bean sprouts. Patient 2 was a male patient in his twenties who also showed positive for mung bean sprouts as well as soybean sprout. Both patients were positive for IgE specific to birch, Gly m4, and Bet v1.Mung beans belong to the PR-10 family because they contain the allergenic component, Vig r1. A cross ...
Source: Allergology International - September 20, 2023 Category: Allergy & Immunology Authors: Tomoko Kobayashi Tomonobu Ito Harutaka Seshimo Chizu Egusa Kazutoshi Harada Yukari Okubo Tomoyuki Niitsuma Source Type: research
Phenotypic changes in mast cells during allergy immunotherapy
Arerugi. 2023;72(8):1026-1031. doi: 10.15036/arerugi.72.1026.NO ABSTRACTPMID:37730345 | DOI:10.15036/arerugi.72.1026
Source: Allergology International - September 20, 2023 Category: Allergy & Immunology Authors: Haruki Sasa Hitoshi Ogata Yosuke Kurashima Source Type: research
Factors that predict pursuing sinus surgery in the era of highly effective modulator therapy
ConclusionsWorse sinonasal symptom burden, lack of ETI treatment, sleep quality, depression, and nasal endoscopy scores were associated with electing ESS, while lung disease severity and sinus CT scores were not. ETI use was associated with lower odds of pursuing ESS independent of sinonasal symptom burden.
Source: International Forum of Allergy and Rhinology - September 20, 2023 Category: Allergy & Immunology Authors: Daniel M. Beswick,
Ethan J. Han,
Jess C. Mace,
Karolin Markarian,
Jeremiah A. Alt,
Todd E. Bodner,
Naweed I. Chowdhury,
Patricia H. Eshaghian,
Anne E. Getz,
Peter H. Hwang,
Ashoke Khanwalkar,
Adam J. Kimple,
Jivianne T. Lee,
Douglas A. Li,
M Tags: ORIGINAL ARTICLE Source Type: research
Increasing wildfire smoke from the climate crisis: Impacts on asthma and allergies
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: John R. Balmes, Stephanie M. Holm Source Type: research
The SARS-CoV-2 Pandemic and Asthma: What We Have Learned and What is still Unknown
The SARS-CoV-2 pandemic has brought new insights into the immunological intricacies of asthma. In this review, we discuss the epidemiology of asthma in patients infected with SARS-CoV-2 and the risk of severe infection. Type 2 inflammation had an overall protective effect against SARS-CoV-2 infection by various mechanisms summarized in this review. Asthma, intranasal, and inhaled corticosteroids decreased the ACE2 receptor, an important receptor for SARS-CoV-2 entry into host cells. We summarize the nuances of treatment of type 2 inflammation despite its underlying protective effects.
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Christa McPhee, Kateryna Yevdokimova, Linda Rogers, Monica Kraft Source Type: research
Reply
To the Editor: We thank Dr Weinberger for his letter and for participation in the recent Delphi consensus survey.1 His letter raises points on terminology, differential diagnosis, and the attribution of exercise-induced symptoms in pediatric populations.
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Paul Leong, James H. Hull, Peter G. Gibson, Thomas Halvorsen, Philip G. Bardin, VCD/ILO Delphi Steering Committee Tags: Correspondence Source Type: research
VCD and ILO are not synonymous
The publication by Leong et al1 synonymizes vocal cord dysfunction (VCD) and a neologism, inducible laryngeal obstruction (ILO). The function of the vocal cords during normal respiration is to abduct during inspiration to maximize air intake. One form of VCD involves paradoxical adduction during inspiration, resulting in obs truction to inspiratory airflow (Fig 1, A). Another type of VCD involves adduction during both inspiration and expiration, resulting in obstruction to airflow throughout the respiratory cycle (Fig 1, B).
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Miles Weinberger Tags: Correspondence Source Type: research
