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An mRNA Vaccine to Treat Cancer
by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines […]
Source: virology blog - April 6, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey cancer cancer vaccine cervical cancer cytotoxic T cells helper T cells HPV HPV E7 human papillomavirus mRNA mRNA vaccine non-replicating mRNA vaccine self-replicating mRNA vaccine tumor Source Type: blogs

Triggering the STING Pathway Suppresses Cancer Metastasis
Most cancers would become manageable if metastasis could be eliminated. A robust way to fully suppress metastasis across all forms of cancer would not be a cure in and of itself, but it would greatly reduce mortality and allow cancers to be managed or eliminated more readily, and with less trauma for the patient. On the way to a hypothetical end to metastasis, researchers are making inroads towards approaches that may at least reduce metastasis to some degree. These approaches often, as here, involve ways to enlist the immune system to more aggressively target and destroy metastatic cells before they can build a new tumor....
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The heartbreaking story of Jimmy Carter: a call for Medicare reform in end-of-life care
The purpose of the serious illness conversation is to offer patients a clear choice between treating and not treating an incurable disease like liver cancer. The goal is to give the person permission to alleviate pain and suffering. The individual might decide to be treated as a patient or honored as a person if given Read more… The heartbreaking story of Jimmy Carter: a call for Medicare reform in end-of-life care originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 4, 2023 Category: General Medicine Authors: Tags: Conditions Palliative Care Source Type: blogs

I ’ m a medical oncologist. Here ’ s why AI isn ’ t going to cure cancer.
As a cancer physician, the amount of data I obtain on my patients is ever-increasing, along with options for cancer therapies. This is, as the saying goes, a good problem to have, but the amount of data management oncologists must do after hours (because there isn’t enough time in the clinic day) to keep up Read more… I’m a medical oncologist. Here’s why AI isn’t going to cure cancer. originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 4, 2023 Category: General Medicine Authors: Tags: Tech Health IT Source Type: blogs

I Have No Mouth, Yet Still I Scream
BY KIM BELLARD In light of the recent open letter from AI leaders for a moratorium on AI development, I’m declaring a temporary moratorium on writing about it too, although I doubt either one will last long (and this week’s title is, if you hadn’t noticed, an homage to Harlan Ellison’s classic dystopian AI short story).  Instead, this week I want to write about plants. Specifically, the new research that suggests that plants can, in their own way, scream.  Bear with me. To be fair, the researchers don’t use the word “scream;” they talk about “ultrasonic airborne sounds,” but just about every ac...
Source: The Health Care Blog - April 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Kim Bellard Microbiome Plants Source Type: blogs

Breaking Bad: the antihero ’ s journey through cancer
An excerpt from From Whispers to Shouts: The Ways We Talk About Cancer. “Walt, is that you?” Skyler asks her husband in the final scene of the Breaking Bad pilot. They’re in bed, she’s pregnant, and he’s come toward her in a new way. He’s changed, and she doesn’t yet know why. In this acclaimed Read more… Breaking Bad: the antihero’s journey through cancer originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 2, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Complicating the Relationship Between Cellular Senescence and Late Life Depression
Inflammatory signaling may be influential in major depressive disorder. For any condition in which inflammation is important, attention should be given to the possible role of cellular senescence, given the advent of senolytic therapies to clear these cells. Senescent cells grow in number throughout the body with age, and while never a large fraction of all cells, they energetically generate pro-inflammatory signals. Here, researchers discuss the sometimes there, sometimes not correlation between burden of senescent cells and incidence of major depressive disorder in later life. Previous studies suggested the role...
Source: Fight Aging! - March 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Aggrephagy in Hematopoietic Stem Cell Aging
Autophagy is the name given to a complex, varied set of processes that tag and recycle broken or excess proteins and structures in the cell. The destination for materials to be recycled is the lysosome, a membrane-wrapped collection of enzymes capable of breaking down near all of the proteins and other molecules a cell is likely to encounter. How materials are selected and how exactly they make their way to the lysosome varies considerably. Alongside autophagy, the ubiquitin-proteasome system is another way for cells to identify problem proteins, such as those that misfold into toxic configurations, and then break them dow...
Source: Fight Aging! - March 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

In Other Words: Not All Bases Are in the Ballpark
You might first think about sports when you hear the word base, but not all bases are on the baseball diamond. In chemistry, a base is a molecule that reacts with an acid, often by accepting a proton from the acid or from water. Baking soda and dish soap are common bases. Credit: NIGMS. A Building Block for Life Bases are found throughout biological systems and in many molecules critical to life. The pH scale measures how acidic or basic (“alkaline”) liquids, such as water or blood, are. Liquids with a pH less than 7 are acidic, while liquids with a pH greater than 7 are basic. Electrolytes, like sodium, ca...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 29, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Molecular Structures DNA In Other Words RNA Source Type: blogs

So We Have Hallmarks of Aging: What Now?
The influential hallmarks of aging paper is now nearly ten years old. It has been twenty years since the Strategies for Engineered Negligible Senescence (SENS) categorization of causative mechanisms of aging was first put forward, an effort that inspired the hallmarks. Time moves on relentlessly! Are you feeling old yet? Unlike SENS, the hallmarks of aging made no attempt to be a to-do list of research and development approaches that we should be undertaking in order to effectively treat aging. They are, as it says on the label, hallmarks, observations of old cells and tissues. Nonetheless, a to-do list is somewhat the way...
Source: Fight Aging! - March 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Murderous capitalism
This essay by Hunter is mostly a summary of a Washington Post story but I ' m sending you there because of the WaPo paywall. It ' s rather long-winded and repetitive -- you ' ll pretty much get the idea before you read to the end.  To put it in a coconut shell, the first main point is that the only purpose of AR-15 rifles and knockoffs thereof is to kill humans. They are military rifles that can get off a lot of not particularly well-aimed shots quickly and that cause horrendous tissue damage. They are not useful for hunting or target shooting or any other conceivable " sport. " They are military weapons designed to k...
Source: Stayin' Alive - March 28, 2023 Category: American Health Source Type: blogs

AI: Not Ready, Not Set – Go!
By KIM BELLARD I feel like I’ve written about AI a lot lately, but there’s so much happening in the field. I can’t keep up with the various leading entrants or their impressive successes, but three essays on the implications of what we’re seeing struck me: Bill Gates’ The Age of AI Has Begun, Thomas Friedman’s Our New Promethean Moment, and You Can Have the Blue Pill or the Red Pill, and We’re Out of Blue Pills by Yuval Harari, Tristan Harris, and Aza Raskin.  All three essays speculate that we’re at one of the big technological turning points in human history. We’re not ready. The subtitle ...
Source: The Health Care Blog - March 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Health care tech Kim Bellard Source Type: blogs

Nanoparticles Get Lymphatic Vessels Pumping
Researchers at the Georgia Institute of Technology have developed a nanotechnological solution for lymphedema, a failure of the lymphatic system that results in uncomfortable and irreversible fluid retention. Previous research efforts have focused on...
Source: Medgadget - March 27, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine News Oncology Surgery Source Type: blogs

Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment. A Vicious Cycle of Heart Failure and Dementia https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/ The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter,...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs