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Data Democracy! ‘Dr. Google’ (2023) Vs. ‘Every Man His Own Physician’ (1767)
BY MICHAEL MILLENSON In the 18th-century, a pre-Google guide offered democratization of medical information In 1767, as American colonists’ protestations against “taxation without representation” intensified, a Boston publisher reprinted a book by a British doctor seemingly tailor-made for the growing spirit of independence. Talk about “democratization of health care information,” “participatory medicine” and “health citizens”! Every Man His Own Physician, by Dr. John Theobald, bore an impressive subtitle: Being a complete collection of efficacious and approved remedies for every disease...
Source: The Health Care Blog - July 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Democritization of Care Healthcare Michael Millenson Participatory medicine Source Type: blogs

Major evidence review supports an “exercise prescription” for most adults to boost mental health and well-being
Conclusion and relevance: Physical activity is highly beneficial for improving symptoms of depression, anxiety and distress across a wide range of adult populations, including the general population, people with diagnosed mental health disorders and people with chronic disease. Physical activity should be a mainstay approach in the management of depression, anxiety and psychological distress. The Study in Context: Can you grow your hippocampus? Yes. Here’s how, and why it matters Three ways to protect your mental health during –and after– COVID-19 Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging ...
Source: SharpBrains - July 6, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning Peak Performance anxiety depression exercise exercise prescription gym improve mental health lift weights medication mental-health-treatment physical-health therapy yoga class Source Type: blogs

Science Snippet: Antioxidants Explained
Many types of fruits, vegetables, and legumes are rich in antioxidants. Credit: iStock. While at the grocery store, you’ve likely noticed foods with labels saying they contain antioxidants, but what does that mean? In short, antioxidants are substances that may prevent or delay some types of cell damage. Many foods, including fruits and vegetables, naturally produce antioxidants like vitamins C and E, beta-carotene, and selenium. Our bodies also naturally produce antioxidant molecules such as alpha-lipoic acid, glutathione, and coenzyme Q10. Antioxidants are united by their ability to donate electrons, whi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 5, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Science Snippet Source Type: blogs

Navitus 2022 Drug Trend Report
   Its been many years since I posted news of a PBM Drug Trend Report. Once upon a time, PBM drug trend reports contained lots of interesting information. However, over time (in 2021, for example, when reports from the preceding year were published), CVS Caremark published only a bare-bones summary, while Prime Therapeutics, MedImpact, and other large PBMs all completelystopped publishing drug trend reports. The reason is basically because its becoming harder and harder for PBMs to present themselves as saving money when the biggest PBMs aren ' t saving any entities any money on prescription drugs anymore (I...
Source: Scott's Web Log - July 5, 2023 Category: Endocrinology Tags: 2022 2023 Drug Trend Report Navitus Navitus Health Solutions PBM Source Type: blogs

Progress Towards Rejuvenation as a Matter of Investment versus a Matter of Time
It is not hard to argue that there is too little investment in progress towards the treatment of aging as a medical condition. Collectively, the underlying mechanisms of degenerative aging are the cause of two-thirds of human mortality, and likely a somewhat greater fraction of loss of function, suffering, and pain. The cost of that mortality is vast, no matter how one likes to model the value of a human life, or a year spent alive in good health. This is much the same argument that can be made for greater investment in medical research in general. Medical research funding as a whole is a very, very tiny fraction of the co...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

The Business Reality of Healthcare AI
BY KIM BELLARD I was at the barbershop the other day and overheard one barber talking with his senior citizen customer about when – not if – robot AIs would become barbers. I kid you not. Now, I don’t usually expect to heard conversations about technology at the barber, but it illustrates that I think we are at the point with AI that we were with the Internet in the late ‘90’s/early ‘00s: people’s lives were just starting to change because of it, new companies were jumping in with ideas about how to use it, and existing companies knew they were going to have to figure out ways to incorporate it if they ...
Source: The Health Care Blog - July 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Healthcare AI healthcare delivery Kim Bellard Source Type: blogs

Age-Associated B Cells Correlate with Impaired Immune Response
Age-associated B cells are one of a number of dysfunctional or maladaptive immune cell subpopulations that appear in increasing numbers in later late, and which likely impair the many functions of the immune system by their presence. Clearing all B cells rather than trying to selectively clear age-associated B cells is a viable proposition, as the B cell population regenerates quite rapidly following clearance, and the new cells lack the age-associated B cell phenotype. This has been demonstrated in animal models, but has yet to make it to the clinic as a treatment to improve the aged immune system. Age-associated...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers. The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

From never-smoker to lung cancer survivor PODCAST
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join us in this episode as we hear the inspiring story of Alice S. Y. Lee, an emergency physician diagnosed with lung cancer despite being a never-smoker. Discover the unique challenges faced by Asian American female nonsmokers, the importance of early detection, and ongoing Read more… From never-smoker to lung cancer survivor [PODCAST] originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 29, 2023 Category: General Medicine Authors: Tags: Podcast Oncology/Hematology Source Type: blogs

Biodegradable Ultrasound Implant Helps Chemo Reach Brain
Researchers at the University of Connecticut have developed an ultrasound implant that can assist in opening the blood brain barrier to allow chemotherapy to enter and treat brain cancer. However, unlike cumbersome ultrasound systems, this technology...
Source: Medgadget - June 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurosurgery Oncology UConn Source Type: blogs

Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar. The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs

The Contribution of Transposons to Differences in Life Span Between Species
Transposable elements in the nuclear genome, also called transposons, are remnant DNA sequences left over from past, often ancient viral infections. A transposon is capable of hijacking the intricate machineries of gene expression to insert further copies of itself into the genome if not suppressed, producing what is effectively DNA damage as these haphazard insertions break existing gene sequences. Further, the transcription of transposon DNA produces viral-like RNA that can provoke an inflammatory innate immune response when present in the cell. Unfortunately, the suppression of transposons weakens with age, allowing the...
Source: Fight Aging! - June 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

This and that
Responding to some of the responses to my last post on global carbon emissions, yes, we agree on the facts, the issue seems to be the implications. It is correct that at this moment, the U.S. accounts for about 15% of global greenhouse gas emissions, and we have been heading downward; while China in particular has been going in the wrong direction and is the largest emitter. Maybe " fairness " is an issue here, since the U.S. is responsible for far more cumulative emissions and China ' s emissions per capita are not as large, but given the crisis facing humanity I think that ' s pretty much beside the point. What matters i...
Source: Stayin' Alive - June 26, 2023 Category: American Health Source Type: blogs

What goes on in the brain matters
I am the first to say (quite loudly at times) that pain is a whole person experience. I say this because my experience of pain is mine and utterly unable to be shared in all its complexity. The only way other people know about my pain is through my actions – both involuntary and voluntary. And even then: the way I express myself differs depending on my social context, my mood, my goals, and what I think my pain represents. Yet when I’m asleep, I don’t have pain, when I have anaesthetic for my colonoscopy, I don’t have pain – so what goes on in my brain is kinda important. Now there have bee...
Source: HealthSkills Weblog - June 25, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Research Therapeutic approaches Source Type: blogs