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In the Long Run, Even Baseline Humans Will Live for a Very, Very Long Time
It is at present somewhat out of style to point out that, yes, obviously, it will be possible in the future to ensure that humans live for a very, very long time. That will be true for even baseline humans lacking all of the various genetic modifications one might propose a future scientific community to be capable of, modifications to introduce the numerous distinct forms of resilience to the mechanisms of mammalian aging exhibited by naked mole-rats, whales, elephants, bats and so forth. Control over aging is a subset of control over molecules and their positions. To be as reductionist as possible, degenerative aging is ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Selective Disruption of Replication in Cancerous Cells by Targeting PCNA
The future of cancer therapy will involve the targeting of mechanisms found broadly in many or all different types of cancer, that cancer cells cannot dispense with as they evolve rapidly within a tumor, and which have little to no effect on non-cancerous cells. Targeting telomerase to prevent the lengthening of telomeres can check the first two of those boxes, leaving the question of how best to effectively restrict the treatment to tumor cells. Targeting alternative lengthening of telomeres can check the second and third boxes, but the mechanism only operates in a minority of cancers. The research community is engaged in...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments
Researchers at the Harvard Wyss Institute have developed an anti-cancer biomaterial treatment that combines adoptive T cell therapy and cancer vaccine technology to treat solid tumors. The researchers have called their technique SIVET, which is short...
Source: Medgadget - August 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology harvard wyssinstitute Source Type: blogs

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Strategy and Tactics: Two Essential Keys to Success
I recently read Outlive by Peter Attia. It’s a book about longevity that I found insightful. It contains many lessons about different aspects of health. However, what I’d like to share with you here isn’t the health lessons from the book. Instead, it’s a quote by Sun Tzu that I found there: Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat. Interesting quote, isn’t it? Strategy without tactics might lead you to victory, but it’s the slowest route to get there. You will waste a lot of resources along the way. On the other hand, tactics without ...
Source: Life Optimizer - August 5, 2023 Category: Consumer Health News Authors: Donald Latumahina Tags: Productivity Thinking Source Type: blogs

Visually Guided Uterine Biopsies in Physician ’s Office: Interview with Allison London Brown, CEO of LUMINELLE
LUMINELLE, a medtech company based in North Carolina, has developed a suite of endoscopic tools that allow clinicians to perform visually guided gynecological procedures right from their office. At present, the majority of uterine biopsies taken to i...
Source: Medgadget - August 4, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ob/Gyn Source Type: blogs

Phreesia Acquires MediFind, Reinforcing its Commitment to Patient-Centered Care and Expanding its Offerings to Consumers
Phreesia, a leader in patient intake, outreach, and activation, is pleased to announce it has acquired Comsort, Inc. d/b/a MediFind (MediFind), a health technology company that uses advanced analytics to help patients—especially those with serious, chronic, and rare diseases—find better care faster. MediFind uses machine learning and proprietary algorithms to continuously review medical information across a wide range of datasets, identifying leading doctors in specific conditions and fields based on factors such as their research output, the volume of patients, and standing among their peers. MediFind assigns four lev...
Source: EMR and HIPAA - August 3, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Chronic Care Comsort Inc. David Linetsky Health IT Acquisitions Healthcare M&A MediFind Patrick Howie Phreesia Rare Diseases Rob Weker Source Type: blogs

Rutin Suppresses the SASP of Senescent Cells
Senescent cells accumulate with age and cause harm via a sustained, energetic production of signal molecules, the senescence-associated secretory phenotype (SASP), that disrupts tissue structure and function. In addition to the search for senolytic drugs that can selectively destroy senescent cells by pushing them into programmed cell death, researchers are also looking for senomorphic drugs that can suppress some or most of the SASP by interfering in its regulatory mechanisms. This seems to me a poor alternative to clearance of senescent cells, as a senomorphic drug must be taken continually, but nonetheless a great many ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Investigating the Secrets of Cancer-Causing Viruses
Credit: Courtesy of Dr. Mandy Muller. While she was in graduate school, Mandy Muller, Ph.D., became intrigued with viruses that are oncogenic, meaning they can cause cancer. At the time, she was researching human papillomaviruses (HPVs), which can lead to cervical and throat cancer, among other types. Now, as an assistant professor of microbiology at the University of Massachusetts (UMass) Amherst, Dr. Muller studies Kaposi sarcoma-associated herpesvirus (KSHV), which causes the rare AIDS-associated cancer Kaposi sarcoma. A Continental Change Dr. Muller has come a long way, both geographically and professionally, s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Infectious Diseases Microbes Profiles RNA Viruses Source Type: blogs

The Top 10 Health Chatbots
This study from March 2023 reports how an app developed to help patients’ bowel preparation can increase compliance and thus, the number of successful colonoscopies. In some cases, health chatbots are also able to connect patients with clinicians for diagnosis or treatment, but that is one step further down the line. The general idea is that in the future, these talking or texting smart algorithms might become the first contact point for primary care. Patients will not get in touch with physicians or nurses or any medical professional with every one of their health questions but will turn to chatbots first. If th...
Source: The Medical Futurist - August 1, 2023 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine Healthcare Design health chatbot Innovation List medical Personalized medicine AI technology digital health chatbots Source Type: blogs

University of Maryland Doctor Tells Public He ' s Not Sure Smoking is Any More Hazardous than Vaping
In anarticle published today byABC News, a physician from the University of Maryland is quoted as telling the public that he isn ' t sure that smoking is any more hazardous than vaping.According to the article: "' We just cannot make a conclusion that it [vaping] is safer than cigarettes, ' said Dr. Jason Rose, a Pulmonary and Critical Care Physician who is also the Associate Professor of Medicine and Associate Dean for Innovation& Physician Science at The University of Maryland. "  Of course, stating that you ' re not sure if vaping is safer than cigarettes is equivalent to saying that you ' re not sure smo...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - July 31, 2023 Category: Addiction Source Type: blogs

Eureka Health Launches with $7 Million For Patient-Led Platform To Share and Discover Better Treatments
Thousands of Members in its Long Covid Community; Expands into Metabolic Disease and Autoimmune Disorders Eureka Health, a new community dedicated to helping chronic disease patients share experiences and discover the latest treatments, launched today to provide hope to people living with chronic diseases. Emerging from stealth with thousands already engaged in its Long Covid group, the AI-powered platform added metabolic disease, autoimmune disorders, ME/CFS, and related conditions. It will expand into other conditions in the coming weeks. The company also announced that it has raised $7 million in funding. The seed rou...
Source: EMR and HIPAA - July 31, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 23andMe Able Partners Adina Teklu Anne Wojcicki Beren Airstone Bling Capital Bow Capital Cancer Commons Eureka Eureka Health Forward Health Health IT Funding Health IT Fundings Health IT Invest Source Type: blogs

Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity. « Back to Top
Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Health misinformation ’ s deadly impact
Turning into vegetarians can cure COVID-19, birth control pills cause abortions, or eating ginger is 10,000 times more effective than chemotherapy at curing cancer were some casually trending health misinformation in the past year. But what is health misinformation, and why is it a serious public health concern? Health misinformation refers to health-related information that Read more… Health misinformation’s deadly impact originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 29, 2023 Category: General Medicine Authors: Tags: Policy Mainstream media Source Type: blogs