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Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment. A Vicious Cycle of Heart Failure and Dementia https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/ The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter,...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A man in his 50s with chest pain
 Sent by anonymous, written by Pendell MeyersA man in his 50s with no prior known medical history presented to the Emergency Department with severe intermittent chest pain. He had episodes of chest pain off and on all night, until about 1 hour prior to arrival when the pain became constant, crushing, 10/10 chest pain that radiated to both arms. He denied any lightheadedness, shortness of breath, vomiting, or abdominal pain. Vitals were within normal limits.Here is his triage ECG at 0343:What do you think?Meyers interpretation: Diagnostic of LAD OMI, with hyperacute T waves in a large LAD distribution including precord...
Source: Dr. Smith's ECG Blog - March 9, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

190 Tuesday Quotes to Give You Motivation and Plenty of Positive Energy
It’s Tuesday. Maybe you’re tired after Monday. And you're ready to restart your week. Or you might want something to help you to keep up the momentum after an energetic and focused start yesterday. In today’s post I’d like to help you out no matter what headspace you're in right now. This is 190 of the best, most motivational and powerful Tuesday quotes. I hope you’ll find something here to help you make this into a fun, fulfilling and excellent week. And if you want even more uplifting inspiration for the week then check out this post with quotes on Wednesday motivation and this one filled with helpful Thursday...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - March 3, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs

Return to McAllen: A Father-Son Interview
By IAN ROBERTSON KIBBE You are going to hear a little more about McAllen, TX on THCB Shortly. And before we dive into what’s happened there lately, I thought those of you who weren’t here back in the day might want to read an article on THCB from July 2009. Where then THCB editor Ian Kibbe interviewed his dad David Kibbe about what he was doing as a primary care doc in McAllen–Matthew Holt By now, Dr. Atul Gawande’s article on McAllen’s high cost of health care has been widely read.  The article spawned a number of responses and catalyzed a national discussion on cost controls and t...
Source: The Health Care Blog - January 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Uncategorized David Kibbe Ian Robertson Kibbe McAllen Physicians TX Source Type: blogs

Ultrasound is Ultra-Cool
This study is also a major step forward for the exciting possibility of combining focused ultrasound with targeted delivery of medications or antibodies that normally have limited capability to cross the blood brain barrier from the blood to the brain.”  Similarly, researchers at Yonsei University College of Medicine (South Korea) found that focused ultrasound improved the delivery of Alzheimer’s drugs by over eight times.  “While there is no complete cure for dementia, we hope that open BBB [blood brain barrier] surgery using FUS surgery can help give hope to dementia patients,” the lead researcher said. ...
Source: The Health Care Blog - January 25, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech 3D printing ChatGPT DSP Kim Bellard Ultrasound Source Type: blogs

Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Healthcare AI – 2023 Health IT Predictions
As we head into 2023, we wanted to kick off the new year with a series of 2023 Health IT predictions.  We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes.  Check out our communities predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media. Check out our community’s healthcare AI predictions. Evangelos Hytopoulos, Sr. Director of Data Science at iRhythm Technologies There is no doubt that AI has become mainstream in many areas....
Source: EMR and HIPAA - January 3, 2023 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Health IT Company Healthcare IT 2023 Health IT Predictions 4D Path Carlene MacMillan CommBox Dave Bennett Evangelos Hytopoulos Gabriel Mecklenburg Healthcare AI Hinge Health iRhythm Technologies Judy Jiao Na Source Type: blogs

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms. The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

65 One Sided Relationship Quotes to Help You Find a Way Forward in Your Life
Being in a one sided relationship isn’t fun. You’re there when they need something. A listening ear. A ride to the airport. Kindness and love when times are tough. But when you need something then they don't help out the way you've done. They may not even answer the phone or listen when you're trying to tell them about the tough week you’ve had. If you are in such a situation then I hope these 65 one sided relationship quotes will be helpful for you. To bring you some comfort and make you see you’re not alone. And more importantly, to help you find a healthy way forward starting today. And if you want even more se...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - December 6, 2022 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs

How much “ pain ed ” do people need? And what to do when someone is not convinced …
This post has been a long time coming. There’s no doubt that giving explanations about pain mechanisms is common, and that we’ve (health professionals) been doing it a looooong time. Yes, way back to the 1970’s! In the early 1980’s when I started working in this field it was already commonplace to offer people an explanation for chronic pain (and to explain why some pains are such pains, while others bother us less – even when they involve the same degree of nociceptive input). Of course, way back then we used Gate Control Theory (GCT) to explain the distinction between hurt and harm, to explo...
Source: HealthSkills Weblog - November 27, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Education/CME Research Science in practice biopsychosocial Explain pain pain explanations PNE Therapeutic approaches Source Type: blogs

Forgiveness
Mrs. Dalai was the love of my life, and I had the great honor of sharing the past 36 years with her. I will miss her more than I can possibly describe. She was often a contradiction in terms. She could be shy, she could be brash. She was retiring, she was outgoing. She felt the presence of God, but she didn ’t much like dealing with religion. She was easy to love, and she could be hard to love. But we loved her anyway. Mrs. Dalai and I met on a blind date on July 19, 1986. For me, it was love at first sight. For her, it took a little longer. She didn’t know what to do with me. She kept telling me to go away, and I kept...
Source: Dalai's PACS Blog - November 24, 2022 Category: Radiology Source Type: blogs

Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer. The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Better Understanding the Outcome of Destroying and Rebuilding the Immune System
The use of chemotherapy to destroy as much of the peripheral immune system as possible, followed by some form of stem cell transplant to rebuild it, has been used for some years as a way to treat multiple sclerosis. In this autoimmune condition, the problem resides in the immune memory, and getting rid of that memory is the solution. The only approach currently demonstrated to work is this somewhat drastic treatment, and the balance of risk and cost means that it is only used for severe diseases such as multiple sclerosis. But in principle, clearance and restoration of the immune system could solve a great many of the issu...
Source: Fight Aging! - November 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
October 27, 2022 Edition-----In the UK we have a political farce running with only a day or so to run when you read this, with a new PM (Rishi Sunak) in place..In the US the mid-term elections are coming in a week or so, thus some concern as to where the US is going!In China Xi has his third 5 year term so we all wonder how that will turn out!In OZ we have has a Budget with floods, inflation, data leaks, the threat of recession, Medicare concerns and other issues just rolling on! At least the Budget does not seem to have broken anything!Overall an ‘omnishambles’ as they say!-----Major Issues.-----https://www.afr.com/wo...
Source: Australian Health Information Technology - October 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs