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Total 88 results found since Jan 2013.

A Sensible Consideration of the State of the Art in the Treatment of Aging as a Medical Condition
It used to be the case that one could write up a summary of where the research community stood on the treatment of aging as a medical condition (which was varying shades of "not that far along towards practical applications, but definitely promising if they get their act together") and then not have to update it all that much for years. Research is slow and uncertain, for one, and secondly there was, for decades, a strong cultural prejudice in the scientific community against trying to apply what was learned about aging to the treatment of aging. Little progress was made as a result. Matters are proceeding much more...
Source: Fight Aging! - January 6, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Planning for Future Pandemics Including Smallpox Outbreaks: Interview with Dr. Phil Gomez, CEO, SIGA Technologies
The COVID-19 pandemic has had significant global consequences, with healthcare systems stretched to their limits, a growing death toll, and economic devastation as economies came grinding to a halt. The pandemic and its aftereffects will be with u...
Source: Medgadget - May 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Public Health Source Type: blogs

Two Things Nearly Everyone Gets Wrong About the Michael Flynn Case
Clark NeilyI ' ve been reading,writing, and tweeting about the Michael Flynn prosecution quite a bit lately, and I ' ve  been getting significant feedback from people who strongly dislike Flynn and think he ' s about to get away with committing a serious crime due to sinister political machinations behind the scenes. As explained in this post, I take no strong position on Flynn ' s character or whether he did or did not commit any crimes —most Americans have, so he ' d be in good company.   But I think many in the " lock him up " crowd are making two  fundamental errors that are in urgent need of correction. Thos...
Source: Cato-at-liberty - May 22, 2020 Category: American Health Authors: Clark Neily Source Type: blogs

" Strike Two " : A Pediatrician ' s " Dance " with Alan Levine/Ballad Health - And WHY We Need Federal Medical Whistle-blower Protection For ALL Healthcare " Workers " NOW
This is the story of how government failed me as a Pediatrician - for the second time.  The saddest thing of all is that there is a " Strike Three " .  Nobody cares about Pediatrics - or Pediatricians.  They haven ' t for a very long time.  This is a long post.  Don ' t whine about it.  Read it. CARE that somebody trying to stand up for your children lived it - and not for the first time.Twenty-two years ago, the morally-bankrupt executives of my now fiscally-bankrupt hometown hospital (in Asheboro, North Carolina) railroaded me out of town . . . after I intervened in a nursery case being...
Source: Dr.J's HouseCalls - May 12, 2020 Category: American Health Tags: Alan Levine Ballad Health Cooperative Agreement COPA ETSU Medical Whistle-blower Pediatric Hospitalist Ralph Northam Randolph Hospital Tennessee Department of Health Virginia Department of Health Source Type: blogs

A Promising Hub For Digital Health: Kazakhstan
Sharing borders with Russia, China, Kyrgyzstan, Uzbekistan, and Turkmenistan, you find the world’s largest landlocked country, the Republic of Kazakhstan. Conversely, with its population of over 18 million spanning across an area of 2,724,900 km², the country also has one of the lowest population densities worldwide, at less than 6 people per square kilometre. Being a relatively new republic and with its widespread inhabitants, Kazakhstan poses as an adequate hub for digital health to expand. Such a young republic’s ministry of health can develop around newer technologies and strategies brought forth with the adven...
Source: The Medical Futurist - March 12, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Healthcare Policy digital health digital health strategy health policy Source Type: blogs

Fight Aging! Newsletter, February 10th 2020
In conclusion, the concept of an epigenetic clock is compelling, but caution should be taken in interpreting associations with age acceleration. Association tests of age acceleration should include age as a covariate. A Discussion of Recent Work on Allotopic Expression of Mitochondrial Genes at the SENS Research Foundation https://www.fightaging.org/archives/2020/02/a-discussion-of-recent-work-on-allotopic-expression-of-mitochondrial-genes-at-the-sens-research-foundation/ A paper published last month outlines recent progress on allotopic expression of mitochondrial genes carried out by the SENS Research ...
Source: Fight Aging! - February 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Notes on the SENS Research Foundation Pitch Day, January 2020
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - January 20, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

9 Pioneers Who Helped Mold the History of Psychology
The profession of psychology dates back nearly 150 years. Throughout that time, many psychologists and other professionals have made significant contributions to the field. And while most casual psychology students know primarily about experimental psychologists, other kinds of psychologists have also made their mark on the profession. Here we walk through a few of the many hundreds of historical moments in psychology. Many of the earliest and most famous psychologists were academics, studying the in what we now call experimental psychology. Experimental psychology is focused on the design and implementation of scientific...
Source: World of Psychology - December 25, 2019 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General History of Psychology Research Source Type: blogs

8 Nootropics to Stimulate Your Brain This Fall
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Nootropics is a term coined by Dr. Corneliu E. Giurgea to describe a class of drugs, supplements, and other synthetic and naturally occurring compounds that improve cognitive function in our brains. They’re often called “smart drugs,” as they can help us think faster and more efficiently. Although used by pretty much everyone, these nootropic supplements are especially popular among younger and olde...
Source: PickTheBrain | Motivation and Self Improvement - September 26, 2019 Category: Consumer Health News Authors: Nadav Dakner Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs

Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Commentary on the Developing UK Government Position on Healthy Longevity
One option for patient advocacy for the treatment of aging as a medical condition is to petition governments and large international organizations such as the World Health Organization to adjust their positions on research funding and goals in medicine. This a fairly popular path, for all that I think it not terribly effective at speeding up the cutting edge of research and development. Large organizations of any sort are inherently conservative, and tend to get meaningfully involved in new fields of human endeavor only long after their support would have been truly influential. Nonetheless, numerous examples of gov...
Source: Fight Aging! - July 26, 2019 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs