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Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics.
Exercise versus the Hallmarks of Aging
https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/
The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Global Science Report: Greenland ’s Resilience in the Face of Apocalyptic Hypotheses
Thirty years ago, NASA scientist James Hansen put greenhouse-effect warming on the map with his stridenttestimony indicating that global temperatures could then confidently be related to changes in atmospheric carbon dioxide. Two years ago, he made another prediction: several meters of sea level rise in this century. HetoldScientific American:Consequences [of climate change] include sea level rise of several meters, which we estimate would occur this century or at latest next century, if fossil fuel emissionscontinue at a high level. That would mean loss of all coastal cities, most of the world ’s large cities and all th...
Source: Cato-at-liberty - June 21, 2018 Category: American Health Authors: Patrick J. Michaels Source Type: blogs
A Failure of the Imagination when it comes to Human Longevity
Researchers recently published a study on attitudes to longevity that is reminiscent of the 2013 Pew survey. When asked, people want to live a little longer than their neighbors, at the high end of the normal life span for old individuals today. When asked how long they want to live given the guarantee of perfect health, people pick a number close to the maximum recorded human life span. This sounds like a collusion between the instinctive desires for first conformity and secondly hierarchy, deeply entwined with the human condition, present in all of our primate cousins, a self-sabotaging gift from our evolutionary heritag...
Source: Fight Aging! - June 21, 2018 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Ending Aging Now Translated into Portuguese
Ending Aging is an important book, a concise explanation of the SENS approach to the development of rejuvenation therapies. It is aimed at laypeople, but with enough depth for scientists to use it as a starting point for their own further reading as well. It covers the extensive evidence gathered by the research community over the decades to support the concept that aging is caused by the accumulation of a few classes of molecular damage to cells and tissues. It outlines proposed therapies that could, if fully developed, repair or work around that damage in order to remove its contribution to aging.
Since its public...
Source: Fight Aging! - June 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
AI Is Close to Giving Us the Ultimate Early Diagnostic Test For Breast Cancer
By HUGH HARVEY, MD
1986 was a great year. In the heyday of the worst-dressed decade in history, the Russians launched the Mir Space Station, Pixar was founded, Microsoft went public, the first 3D printer was sold, and Matt Groening created The Simpsons. Meanwhile, two equally important but entirely different scientific leaps occurred in completely separate academic fields on opposite sides of the planet. Now, thirty two years later, the birth of deep learning and the first implementation of breast screening are finally converging to create what could be the ultimate early diagnostic test for the most common cancer in wom...
Source: The Health Care Blog - March 5, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
The Case of the Brew Master ' s Plot - Was the Veterans Affairs Secretary ' s Travel Spending Scandalous, or Was He Framed in a Plot to Oust a Political Moderate?
DiscussionDr David Shulkin, a holdover appointee of President Obama who was nominated to be Secretary of Veterans Affairs by President Trump, was alleged by the VA Inspector General to have committed various ethical violations involving a trip to Europe the Secretary took with his wife. This appeared to be just the latest in a string of travel-related scandals by top officials of the Trump administration.When this was first reported, I was inclined to see Dr Shulkin as an entitled, and conflicted former health care executive who ran afoul of the government ' s strict ethical standards. (Dr Shulkin ' soffi...
Source: Health Care Renewal - February 19, 2018 Category: Health Management Tags: Donald Trump ill-informed management mission-hostile management political ideology politics Veterans Affairs Source Type: blogs
Fight Aging! Newsletter, January 15th 2018
This study is the longest, prospective randomized controlled trial that has documented the physiological effects of supervised, structured exercise training in a group of sedentary but healthy middle-aged adults. The key finding is that 2 years of exercise training performed for at least 30 minutes, 4 to 5 days per week, and including at least 1 high-intensity interval session per week results in a significant reduction in LV chamber and myocardial stiffness. The use of high-resolution, invasively measured LV pressure-volume curves and comparison with an attention control group enhances the confidence in this conclusion. T...
Source: Fight Aging! - January 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Greatest and Weirdest Digital Health Innovations at CES 2018
With more than a hundred exhibitors, countless new ideas and exciting innovations digital health truly conquered Las Vegas and CES 2018. Just as last year, we decided to show you the most and least impressive healthcare-related gadgets, sensors, trackers, and more importantly, the discernible trends.
2018 – The year when digital health arrived at CES
Would you like to play ping-pong with a robot? Do you want to try an air taxi? If you responded to both questions with “hell yes!” (how else, really), then your place is in the venues hosting CES. Innovators and tech fanatics flock to Las Vegas every January to k...
Source: The Medical Futurist - January 11, 2018 Category: Information Technology Authors: nora Tags: Future of Medicine AI ces CES 2018 digital digital health Health 2.0 Healthcare Innovation Personalized medicine robotics technology trackers wearables Source Type: blogs
The changing needs of a cell: No Membrane? No Problem!
Russian nesting dolls. Credit: iStock.
How “membrane-less” organelles help with key cellular functions
Scientists have long known that animal and plant cells have specialized subdivisions called organelles. These organelles are surrounded by a semi-permeable barrier, called a membrane, that both organizes the organelles and insulates them from the rest of the cell’s mix of proteins, salt, and water. This set-up helps to make cells efficient and productive, aiding in energy production and other specialized functions. But, because of their semi-permeable membranes, organelles can’t regroup and reform in respons...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 3, 2018 Category: Research Authors: Kathryn Calkins Tags: Cell Biology Cells Cellular Processes Nucleolus Organelles Proteins RNA Source Type: blogs
Matthew Holt ’ s EOY 2017 letter (charities/issues/gossip)
Right at the end of every year I write a letter summarizing my issues and charities. And as I own the joint here, I post it on THCB! Please take a look–Matthew Holt
Well 2017 has been quite a year, and last year 2016 I failed to get my end-of-year letter out at all. This I would like to think was due to extreme business but it probably came down to me being totally lazy. On the other hand like many of you I may have just been depressed about the election–2016 was summed up by our cat vomiting on our bed at 11.55 on New Years Eve.
Having said that even though most of you will never comment on this letter and I ...
Source: The Health Care Blog - December 31, 2017 Category: Consumer Health News Authors: Matthew Holt Tags: Matthew Holt Charity Patient Activism Source Type: blogs
The Boys From Silicon Valley
By MARGALIT GUR-ARIE
A few weeks ago one man, named @jack, decided that millions of people will be allowed to use up to 280 characters when expressing themselves on Jack’s public square platform. One man decides how many letters each and every one of us, including the “leader of the free world”, can use when we talk to each other. Just like that. Nobody seemed the least bit perturbed by this notion. Another dude, named Mark, decided to ask people for nude pictures of themselves, so he can better protect them from the bad guys. We shrugged that off too. Then, in a most embarrassing exercise in public humiliation, our ...
Source: The Health Care Blog - December 14, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Dopamine Labs Keytruda Mark Zuckerberg Sean Parker Techno-drugs Source Type: blogs
Fight Aging! Newsletter, December 4th 2017
In this study, we integrated atomic force microscopy (AFM) and molecular approaches to determine whether increased stiffness of aortic VSMCs in hypertensive rats is ROCK-dependent, and whether the anti-hypertensive effect of ROCK inhibitors contributes to the reduction of aortic stiffness via changing VSMC mechanical properties.
Despite a widely held belief that aortic stiffening is associated with changes in extracellular matrix proteins and endothelial dysfunction, our recent studies demonstrated that intrinsic stiffening of aortic VSMCs, independent of VSMC proliferation and migration, is an important contributo...
Source: Fight Aging! - December 3, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Remembering Uwe
By JEFF GOLDSMITH
The healthcare world learned with great sadness this week of the passing of our friend, Uwe Reinhardt. I met Uwe in 1982 at the Federation of American Hospitals meeting in Las Vegas. Uwe opened the meeting by apologizing, in his disarming German accent, for not being his usual sharp self. He had, he said, skipped breakfast because his wife May had instructed him not to pay for anything in Las Vegas that he could get for free at home. This was vintage Reinhardt, innocent and knowing at the same time. That meeting was the beginning of a long and warm friendship.
Uwe would have been acutely uncomfortable wi...
Source: The Health Care Blog - November 15, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, October 30th 2017
In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.
The scientists used C. elegans (nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab. Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms' diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or "youthful" state. In add...
Source: Fight Aging! - October 29, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Yuri Deigin of Youthereum Genetics: the Merging of an Initial Coin Offering and Pluripotency Factors
Initial coin offerings (ICOs) are driving most of the light and heat in the blockchain world these days. People are raising enormous sums in cryptocurrencies for ventures with somewhere between little plausibility and ordinary levels of startup plausibility. In many ways it looks a lot like the last years of the internet bubble way back when; there are a lot of parallels. The flows of funding may be driven by some combination of people bypassing Chinese currency controls, early holders of Bitcoins and Ether diversifying their holdings within the blockchain ecosystem, and various large investment concerns whose owners have ...
Source: Fight Aging! - October 27, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
