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Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Shelterin via TRF1 to Degrade Telomeres in Cancer Cells
Cancer cells depend on lengthening their telomeres, usually via telomerase activity. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. A little length is lost with each cell division, and when short a cell either self-destructs or becomes senescent and ceases replication. Cancer cells can only replicate continually if telomeres are extended continually. Thus some research groups are looking into sabotage of telomerase or the alternative lengthening of telomeres (ALT) processes as the basis for a truly universal cancer therapy. Others, as here, are investigating ways to interfere in mechanisms tha...
Source: Fight Aging! - July 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 17th 2019
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activiti...
Source: Fight Aging! - June 16, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence as a Program of the Innate Immune System
We describe here an essential innate immune signaling pathway in oncogene-induced senescence (OIS) established between TLR2 and acute-phase serum amyloid A1 and serum amyloid A2 (A-SAAs) that initiates the senescence-associated secretory phenotype (SASP) and reinforce cellular senescence in vitro and in vivo. We also identify new important SASP components, A-SAAs, which are the senescence-associated damage-associated molecular patterns (DAMPs) sensed by TLR2 after oncogenic stress. Therefore, we are reporting that innate immune sensing is critical in senescence. We propose that cellular senescence shares mechanistic featur...
Source: Fight Aging! - June 14, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 10th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 9, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Recap of the first day of the AANP annual meeting
Dr. Maria Martinez-Lage was kind enough to write the following summary of events at today ’s American Association of Neuropathologists meeting in Atlanta:The opening day of the 95th Annual Meeting of the American Association of Neuropathologists in Atlanta featured a special course dedicated to a topic both old and new: what happens when treatments go awry? Under the title “Unintended Consequences: The Iatrogenic Neuropathology of Systemic Therapies” the faculty discussed neurologic adverse effects of novel immunotherapies,other cancer and non-cancer related treatments, a...
Source: neuropathology blog - June 7, 2019 Category: Radiology Tags: meetings Source Type: blogs
Senolytic Therapies to Clear Senescent Cells Should Benefit Cancer Patients
It is well known that the present dominant approaches to cancer therapy - meaning toxic, damaging chemotherapy and radiotherapy, only slowly giving way to immunotherapy - produce a significant burden of senescent cells. Indeed, forcing active cancer cells into senescence is the explicit goal for many treatments, and remains an aspirational goal for a large fraction of ongoing cancer research. Most senescent cells self-destruct, or are destroyed by the immune system, but some always linger - and more so in older people, due to the progressive incapacity of the immune system. An immune system that becomes ineffective in supp...
Source: Fight Aging! - June 6, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Progress Towards Blocking Alternative Lengthening of Telomeres in Cancer
Well, this is promising news. Researchers have found that inhibition of FANCM activity is a potential point of intervention to shut down alternative lengthening of telomeres (ALT) in cancer. This goal is one half of the ultimate cancer therapy, a form of treatment that is (a) capable of shutting down all forms of cancer, without exception, where (b) cancers cannot evolve resistance to its mechanisms, and (c) it requires little to no expensive, time-consuming adaptation for delivery to different cancer types. The other half is a method of blocking the ability of telomerase to lengthen telomeres, and several research groups ...
Source: Fight Aging! - June 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Conservative View of the Present State of Senolytic Development for Rejuvenation
Here, one of the leading researchers working on the biochemistry of senescent cells - and their relevance to aging - considers the state of development of senolytic therapies. These are treatments, largely small molecule drugs at this stage, but also including suicide gene therapies, immunotherapies, and more, that are capable of selectively destroying some fraction of the senescent cells present in old tissues. There is tremendous enthusiasm in the scientific and development communities for the potential to create significant degrees of rejuvenation via this approach. The results in mice are far and away more impressive a...
Source: Fight Aging! - May 22, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MIXiii-BIOMED 2019 Conference – Early Registration by Wednesday, May 1
This is the last week to register at the discounted early registration rates for the 18th MIXiii-BIOMED Conference and Exhibition, taking place May 14-16 at The David InterContinental Hotel, Tel Aviv, Israel.
As Israel’s leading life scienc...
Source: Medgadget - April 23, 2019 Category: Medical Devices Authors: MIXiii-BIOMED Tags: Sponsored Content Source Type: blogs
Short Wavelength Ultrasound Helps Drugs Get Inside Brain Safer
Getting drugs to treat maladies in the brain is hampered by the blood-brain barrier, a protective shield that makes sure only the right chemicals pass through. Ultrasound has become a promising way of opening up pathways in the blood-brain barrier to...
Source: Medgadget - April 1, 2019 Category: Medical Devices Authors: Editors Tags: Medicine Neurology Radiology Source Type: blogs
Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019
Jim Mellon's Juvenescence venture is at present one of the few major venture organizations focused on approaches to treat aging as a medical condition. Mellon and his colleagues outlined their take on the field in a 2017 book, also called Juvenescence. We are fortunate in that he is among the first few high net worth individuals to both agree with the SENS philosophy of damage repair, and then, much more importantly, follow through in action as well as word. He is not just seeing a massive market opportunity in treating aging, though that is certainly there, but is doing this because he wishes to achieve the goal of radica...
Source: Fight Aging! - March 4, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, March 4th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
