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Cancer-killing viruses
by Gertrud Rey Although cancer therapies have improved dramatically in recent years, the main options for treating cancer still consist of surgery, chemotherapy, and radiation therapy. This limitation is a problem for aggressive cancers like glioblastoma multiforme (GBM), brain cancers which are typically resistant to traditional therapies. GBM is a high grade glioma, an aggressive […]
Source: virology blog - February 28, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information glioblastoma multiforme herpes simplex virus viral viral oncotherapy viruses Source Type: blogs
Request for Startups in the Rejuvenation Biotechnology Space, 2019 Edition
I am a little late with the 2019 list of projects in rejuvenation biotechnology that I'd like to see startups tackling sometime soon. In my defense, this year I have a startup of my own to keep up with, and the first part of 2019 was a wall to wall series of conferences alternating between the US and Europe. It continues to be the case that this is a new industry of near endless potential, yet little of that potential is under active development. This is the state of affairs despite the arrival of hundreds of millions of dollars in venture funds managed by the like of Juvenescence, Life Biosciences, and so on. The research...
Source: Fight Aging! - February 25, 2019 Category: Research Authors: Reason Tags: Investment Source Type: blogs
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent well known to cause coronary vasospasm:Correct answer: c) 5-fluorouracil
5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrh...
Source: Cardiophile MD - February 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Fight Aging! Newsletter, February 18th 2019
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - February 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Oglionucleotides that Interfere in Telomerase Activity Without Killing Cells
It seems reasonable to think that sabotaging the lengthening of telomeres might prove to be the basis for a universal cancer therapy, capable of shutting down all cancers. Unfettered telomere lengthening is required by all cancers in order to permit rampant replication and growth. Without that capability, the cancer will wither. Telomere length is a part of the mechanism limiting cell replication; cells lose a little of that length with each cell division, and short telomeres force senescence or self-destruction via programmed cell death. In normal tissues only stem cells use telomerase in order to maintain lengthy telomer...
Source: Fight Aging! - February 14, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging.
Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia
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Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Past Progress Towards Control of Cancer Has Been Slow, Steady, and Incremental
Mortality rates for cancer have diminished slowly and steadily over the past few decades. This is a matter of prevention on the one hand and improvements in early detection of cancer on the other. When caught early enough, even comparatively crude approaches to therapy have a decent chance of controlling and eliminating the cancer. This trend will no doubt continue, but the more rapid, more effective progress that we'd like to see will only emerge given the advent of universal cancer therapies, those that strike at mechanisms, such as telomere lengthening, that are shared by many or all cancers. That is a plausible goal fo...
Source: Fight Aging! - January 23, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Immunotherapy: What you need to know
Not all that long ago, chemotherapy was the only option to treat most advanced (metastatic) cancers. Because these drugs work by destroying rapidly dividing cells, they harm some healthy cells — such as hair follicles — as well as cancer cells. In the past two decades, cancer treatment has been transformed by targeted drugs and the emergence of chemotherapy. Targeted drugs are designed to home in on specific genes or proteins that are altered or overexpressed on cancer cells. Immunotherapy has been very successful for certain types of advanced cancers, such as lung, bladder, and skin cancers.
One form of immunotherapy ...
Source: Harvard Health Blog - January 22, 2019 Category: Consumer Health News Authors: Guru P. Sonpavde, MD Tags: Cancer Immunotherapy Managing your health care Source Type: blogs
Bad breath: What causes it and what to do about it
Almost everyone experiences bad breath once in a while. But for some people, bad breath is a daily problem, and they struggle to find a solution. Approximately 30% of the population complains of some sort of bad breath. Halitosis (Latin for “bad breath”) often occurs after a garlicky meal or in the morning after waking. Other causes of temporary halitosis include some beverages (including alcoholic drinks or coffee) and tobacco smoking.
Some people may not be aware of their own halitosis and learn about it from a relative, friend, or coworker, causing some degree of discomfort and distress. In severe cases, bad breath ...
Source: Harvard Health Blog - January 21, 2019 Category: Consumer Health News Authors: Alessandro Villa DDS, PhD, MPH Tags: Dental Health Source Type: blogs
BioethicsTV (January 15-17, 2019): #TheResident, #TheGoodDoctor, #NewAmsterdam, #ChicagoMed
by Craig Klugman, Ph.D.
Jump to The Resident (Season 2; Episode 10): What would you do doctor?a>;Jump to The Good Doctor (Season 1; Episode 11): Ignoring patient rights; unnecessary risks; crisis planning; Jump to New Amsterdam (Season 1; Episode 11): Superutilizers and racism; Jump to Chicago Med (Season 4; Episode 11): Triage, gestational surrogacy conflicts; ends justifies the means
The Resident (Season 2; Episode 10): What would you do doctor?
As Hunter is released from prison on murder charges for killing patients with unneeded cancer therapy (sometimes on people without cancer), one of her victims is in the ED wi...
Source: blog.bioethics.net - January 19, 2019 Category: Medical Ethics Authors: Craig Klugman Tags: BioethicsTV Conflict of Interest Decision making End of Life Care Featured Posts Informed Consent professional ethics Public Health Reproductive Ethics Source Type: blogs
Fight Aging! Newsletter, December 3rd 2018
This article, however, is more of a commentary on high level strategy and the effects of regulation, coupled with a desire to forge ahead rather than hold back in the matter of treating aging, thus I concur with much more of what is said than is usually the case.
For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. At present, excellent reasoning suggests aging should be defined as a disease - indeed, aging has been referred to as "normal disease." Aging is the sum of all age-related diseases and this sum is the best biomarker of aging. Aging and its diseases ar...
Source: Fight Aging! - December 2, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Else can be Achieved with Better Control of Senescent Cells?
At the present time, the main focus of therapeutic development involving senescent cells is the safe, selective destruction of as many such cells as possible. The accumulation of senescent cells is an important cause of aging and age-related pathology, and removing even just a quarter or a half of them - and in only some organs and tissues - has been shown to significantly extend life and improve health in mice. The first human trials are underway and the results will be published over the next year or so.
While senescent cells do a good job of accelerating our demise, it is undeniably the case that these cells also...
Source: Fight Aging! - November 29, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Further Evidence for Cancer Treatments to Accelerate Aging
People who have undergone chemotherapy or radiotherapy suffer a reduced life expectancy and increased risk of suffering other age-related conditions even when the cancer is defeated. These cancer therapies produce large numbers of senescent cells, both as a result of their toxicity and because they force cancerous cells into senescence. It is quite likely that this is the primary mechanism by which successful cancer treatments nonetheless shorten later lifespan. This could be considered a true form of accelerated aging, as the accumulation of senescent cells is one of the root causes of aging. These cells secrete signals t...
Source: Fight Aging! - November 29, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Is cancer truly the enemy?
Cancer is the enemy. So, our immediate desire is to get rid of it, throw it away, and never hear from it again. Current therapies that require living tissue are proving that false. We know that your living tumor tissue is like your fingerprint, unique to each individual patient. It contains information specific to you, your genetic make-up, your cancer and ultimately the thought is, your treatment. If kept alive, instead of being thrown away as medical waste in the operating room, it can unlock treatment options that might not otherwise be considered and save patients from side-effects of ineffective treatmen...
Source: Kevin, M.D. - Medical Weblog - October 26, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/ken-dixon" rel="tag" > Ken Dixon, MD < /a > Tags: Conditions Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, October 22nd 2018
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity.
RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes
https://www.fightaging.org/archives/...
Source: Fight Aging! - October 21, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
