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An Investigation of How Telomerase Cancers can Switch to Become ALT Cancers
The paper I'll point out today is a timely one, given that the SENS Research Foundation's fundraiser for early stage work on a therapy for alternative lengthening of telomeres (ALT) cancers is nearing its close. There are still thousands of dollars left in the matching fund, so give it some thought if you haven't yet donated. The search for ways to safely sabotage ALT is a useful, important line of research because (1) blocking telomere lengthening is a path to a universal cancer therapy, (2) those research groups presently working on it are all looking to achieve this goal by interfering in the activities of telomerase, (...
Source: Fight Aging! - September 3, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 22nd 2016
This study provides additional fuel to really bolster research efforts by us and others in geroscience, a field that seeks to understand relationships between the biology of aging and age-related diseases. Aging is the most important risk factor for common chronic conditions such as heart disease, Alzheimer's and cancer, which are likely to share pathways with aging and therefore interventions designed to slow biological aging processes may also delay the onset of disease and disability, thus expanding years of healthy and independent lives for our seniors." Longer-Lived Parents and Cardiovascular Outcomes ...
Source: Fight Aging! - August 21, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A New $15,000 Challenge Grant Announced for SENS Cancer Research Crowdfunding
Earlier today at the Rejuvenation Biotechnology 2016 conference, the SENS Research Foundation folk announced a $15,000 challenge grant for the present OncoSENS cancer research crowdfunding effort. All donations from here forward will be matched dollar for dollar from the grant, and the deadline for the fundraiser has been extended for another thirty days to give this a chance to run. The funds raised from the community through this initiative will be used to carry out the first high-throughput screening of drug candidates for cancers that use the alternative lengthening of telomeres (ALT) mechanism to maintain their growth...
Source: Fight Aging! - August 17, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, August 15th 2016
In conclusion, our results demonstrate that circulating GDF11 levels are reduced in our mouse model of premature aging, which shares most of the symptoms that occur in normal aging. However, GDF11 protein administration is not sufficient to extend longevity in these progeroid mice. Although accelerated-aging mouse models can serve as powerful tools to test and develop anti-aging therapies common to both physiological and pathological aging, the existence of certain differences between the two processes implies that further investigation is still required to determine whether long-term GDF11 administration has a pro-surviva...
Source: Fight Aging! - August 14, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Crowdfunding a Universal Cancer Treatment: Only a Few Days Left in the Fundraiser
This year's SENS rejuvenation research crowdfunding event puts the spotlight on the SENS Research Foundation's cancer program. So far more than 300 people have donated, and more than $26,000 has been raised; with ten days left to go, it won't take that much more of an effort to reach the same number of donors and the same level of support given to last year's fundraiser, and which led to the success in that research program. As for all of the SENS research initiatives in the science of aging, the SENS Research Foundation's work on cancer aims to support a big, bold goal in medicine: to build a single type of therapy that c...
Source: Fight Aging! - August 8, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, August 1st 2016
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 31, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Review of Telomerase as a Therapeutic Target
Telomerase provides the primary mechanism by which cells lengthen their telomeres. In our species only stem cells and cancer cells do this, while in mice more types of cell use more telomerase. Telomere length determines the limit to cell divisions, a little of the length being lost each time a cell divides. Cells that can lengthen their telomeres can continue dividing indefinitely, and that is how stem cells can continually deliver a useful supply of daughter cells to support surrounding tissues. It is also how cancer grows. Cancer and regeneration are the two sides of the same coin of growth and regeneration, one control...
Source: Fight Aging! - July 30, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

More Details on SENS Research Foundation ' s ALT Cancer Program
The SENS Research Foundation is currently raising funds for the next step in its cancer research program: building one of the necessary foundations for a universal cancer therapy, one form of treatment that can in principle halt all types of cancer. This requires putting a stop to the lengthening of telomeres in cancer cells, as without that ability cancer tissue cannot grow and spread. This is the one actionable common mechanism shared by all cancers. Cancer cells can use telomerase or alternative lengthening of telomeres (ALT) to extend telomere length, and while some research groups are working on telomerase inhibition,...
Source: Fight Aging! - July 27, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 25th 2016
This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke. To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
Source: Fight Aging! - July 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Targeting CD47 to Reduce Atherosclerotic Plaques in Blood Vessels
In recent news, researchers have identified CD47, mainly of interest in cancer therapies up until this point, as a potential therapeutic target to diminish the vicious circle of mechanisms that causes fatty plaques to grow in blood vessel walls. Everyone suffers from this problem as they age, and it leads to the condition known as atherosclerosis. The plaques start as tiny areas of inflammation, spawned by an overreaction to damaged lipid molecules, but this can spawn a cycle of ever greater inflammation, futile immune system intervention, and cell death that produces a growing graveyard of cell debris and fats. The result...
Source: Fight Aging! - July 21, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Aubrey de Grey AMA at /r/Futurology: the SENS Approach to Cancer and More
Today, July 19th, Aubrey de Grey of the SENS Research Foundation and Haroldo Silva, lead SENS cancer researcher, are hosting an AMA - Ask Me Anything - event at /r/futurology. They will be there for a few hours to answer questions on rejuvenation research, fundraising for work on aging and cancer, and other aspects of the work of the SENS Research Foundation. This is a chance to ask about the SENS approach to a universal cancer therapy, one that targets the common mechanism of telomere lengthening that all cancers must employ to grow. The SENS researchers are focused on alternative lengthening of telomeres, ALT, a collecti...
Source: Fight Aging! - July 19, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Introducing Viral Cancer Therapies into the Spleen Greatly Improves Outcomes
There are plenty of results from the past decade to illustrate that the methodology by which a therapy is delivered makes a great deal of difference to the outcome in patients. Here, for example, researchers have found a way to improve the performance of viruses engineered to preferentially target cancer cells. We've been hearing less of this approach to cancer in the past few years, given the progress and more widespread support for cancer immunotherapy as a technology platform, but there are still many researchers working on the use of viruses in targeted cancer therapy, and a number of promising studies have resulted. ...
Source: Fight Aging! - July 19, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Matching Fund Donors Sought for SENS Universal Cancer Therapy Crowdfunding
There is a month left to go in the SENS crowdfunding campaign that aims to accelerate development of an important component of a universal cancer therapy, a way to block the mechanisms of telomere lengthening that every type of cancer depends upon. The SENS Research Foundation and Lifespan.io volunteers are looking for donors to put up matching funds of a few thousand dollars or more, in order to take that news and that inducement to a number of conferences and other events over the next few weeks. More than 150 people have donated to the campaign to date, and we'd like to triple that number in the next 30 days. To ...
Source: Fight Aging! - July 18, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, July 11th 2016
In conclusion, hTERT expression strictly limits telomerase activation in most of somatic cells, whereas mTERT expression is detectable in most of mouse tissue cells. The interspecies differences between human and mice suggest an improved mouse line, in which both telomerase regulation and telomere length controls are humanized, would considerably benefit the studies of human aging and cancer using mouse models. ON CELLULAR REPROGRAMMING AND CELLULAR REJUVENATION https://www.fightaging.org/archives/2016/07/on-cellular-reprogramming-and-cellular-rejuvenation/ The commentary linked below takes a look at some rece...
Source: Fight Aging! - July 10, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Microfluidic Device to Test Electric Fields on Cancer Cells
At the post-grad research collaboration called Singapore-MIT Alliance for Research and Technology (SMART), a team has developed a microfluidic device for testing how electric fields influence living cells. The main goal for the technology is to iden...
Source: Medgadget - July 8, 2016 Category: Medical Equipment Authors: Editors Tags: Genetics Oncology Source Type: blogs