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Insomnia in neurological disorders: Prevalence, mechanisms, impact and treatment approaches
Rev Neurol (Paris). 2023 Aug 22:S0035-3787(23)01005-6. doi: 10.1016/j.neurol.2023.08.008. Online ahead of print.ABSTRACTInsomnia is more prevalent in neurological disorders compared to the general population, with rates ranging from 11 to 74.2% in neurodegenerative disorders, 20 to 37% in vascular diseases, 13.3 to 50% in inflammatory diseases, 28.9 to 74.4% in epilepsy, and nearly 70% in migraines. Insomnia in neurological disorders stems from a variety of factors, encompassing physical and neuropsychiatric factors, behavioral patterns, and disruptions in the biological clock and circadian rhythm. There are bidirectional ...
Source: Revue Neurologique - August 24, 2023 Category: Neurology Authors: R de Bergeyck P A Geoffroy Source Type: research

Being Intentional About Your Mental Health and Migraines
Migraines can be occasional and unpredictable and chronic and long-term. After dealing with pain for a while, it can start to impact your mental and emotional health. A renewed focus on your mental well-being may help.
Source: WebMD Health - August 23, 2023 Category: Consumer Health News Source Type: news

Stopping Migraines From Becoming a 'Thief of Joy'
For Michele Jordan, one of WebMD’s migraine bloggers, some of her favorite things – flowers and perfume – trigger her migraines. She didn’t let that stop her from enjoying her favorite scents on a recent trip to Paris.
Source: WebMD Health - August 23, 2023 Category: Consumer Health News Source Type: news

Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study
ConclusionsFull doses and microdoses may hold value in the treatment of some specific chronic pain conditions.SignificancePsychedelic substances are receiving increasing attention from the scientific literature because of evidence showing beneficial effects on several measures related to mental health in clinical samples and healthy volunteers samples. Previous evidence suggests that people suffering from chronic pain are using psychedelics to seek relief and the present paper presents the results of a survey study investigating their use and analgesic effects among individuals suffering from fibromyalgia, arthritis, migra...
Source: European Journal of Pain - August 21, 2023 Category: Anesthesiology Authors: Mauro Cavarra, Natasha Leigh Mason, Kim P. C. Kuypers, Valerie Bonnelle, Will J. Smith, Amanda Feilding, Pamela Kryskow, Johannes G. Ramaekers Tags: ORIGINAL ARTICLE Source Type: research

Phenotypes of undiagnosed adults with actionable < em > OTC < /em > and < em > GLA < /em > variants
HGG Adv. 2023 Jul 29;4(4):100226. doi: 10.1016/j.xhgg.2023.100226. eCollection 2023 Oct 12.ABSTRACTInherited metabolic disorders (IMDs) are variably expressive, complicating identification of affected individuals. A genotype-first approach can identify individuals at risk for morbidity and mortality from undiagnosed IMDs and can lead to protocols that improve clinical detection, counseling, and management. Using data from 57,340 participants in two hospital biobanks, we assessed the frequency and phenotypes of individuals with pathogenic/likely pathogenic variants (PLPVs) in two IMD genes: GLA, associated with Fabry diseas...
Source: Adv Data - August 18, 2023 Category: Epidemiology Authors: Jessica I Gold Sarina Madhavan Joseph Park Hana Zouk Emma Perez Alanna Strong Theodore G Drivas Amel Karaa Marc Yudkoff Daniel Rader Regeneron Genetics Center Penn Medicine BioBank Robert C Green Nina B Gold Source Type: research

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study
ConclusionIn the study, it was observed that among the 10 lipid-lowering drug targets investigated, LPL and HMGCR showed significant associations with migraine risk. These findings indicate that LPL and HMGCR have the potential to serve as candidate drug targets for the treatment or prevention of migraines.
Source: The Journal of Headache and Pain - August 18, 2023 Category: Neurology Source Type: research

Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations
AbstractDue to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies. One drug that is now being used for a variety of conditions is topiramate. This is a narrative review that used PubMed, Google Scholar, MEDLINE, and ScienceDirect to review literature on the clinical and pharmacologic properties of topiramate. Topiramate is a commonly prescribed second-generation antiseizure drug. The drug works through multiple pathways to prevent seizures. In this regard, topiramate blocks sodium and calcium voltage-gated channels, inhibits glutamate r...
Source: Advances in Therapy - August 16, 2023 Category: Drugs & Pharmacology Source Type: research

Understanding migraine symptoms in children
If you’ve experienced a migraine headache before, the sensation is often very distinct: throbbing pain, sensitivity to light and loud noise, and sometimes nausea and vomiting. Migraine symptoms can be uncomfortable and distressing. Equally concerning is when a migraine sufferer recognizes these symptoms in their child. Migraines typically emerge during early adolescence, particularly when females Read more… Understanding migraine symptoms in children originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - August 14, 2023 Category: General Medicine Authors: Tags: Conditions Neurology Pediatrics Source Type: blogs

' Magic Mushroom ' Drug Psilocybin Shows Early Promise in Easing Migraines
MONDAY, Aug. 14, 2023 -- Psilocybin, the active ingredient in " magic " mushrooms, is getting renewed interest as a potential treatment for various health conditions. Now, a new research review argues that migraines should be added to that...
Source: Drugs.com - Daily MedNews - August 14, 2023 Category: General Medicine Source Type: news

Column: Madness  and migraines? Side effects of trying to negotiate the Medicare maze
Good luck trying to manage Medicare. As I waded through the possibilities, I started to see waves of bright light roll across my computer screen -- a visual aura migraine, columnist Steve Lopez writes.
Source: L.A. Times - Health - August 12, 2023 Category: Consumer Health News Authors: Steve Lopez Source Type: news

NHS patients could receive a daily pill which can HALF the frequency of their crippling migraine headaches
The new treatment is a type of medication called a CGRP inhibitor, which blocks the effect of calcitonin gene-related peptide - a protein known to trigger debilitating migraines.
Source: the Mail online | Health - August 5, 2023 Category: Consumer Health News Source Type: news

Galcanezumab in patients with episodic migraine: results from the open-label period of the phase 3 PERSIST study
ConclusionsGalcanezumab was efficacious and well-tolerated in patients with episodic migraine from China, India and Russia, for up to 6  months.Trial registrationClinicalTrisABSTRACT_pals.gov NCT03963232, registered May 24, 2019.
Source: The Journal of Headache and Pain - August 4, 2023 Category: Neurology Source Type: research