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Cancer: Carcinoma
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Total 98998 results found since Jan 2013.
Role of organic cation transporter 3 (OCT3) in the response of hepatocellular carcinoma to tyrosine kinase inhibitors
In conclusion, analysis by immunohistochemistry of OCT3 in the PM of tumor cells may help to predict the response of HCC patients to sorafenib and potentially to other TKIs.PMID:37722628 | DOI:10.1016/j.bcp.2023.115812
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Elisa Herraez Ruba Al-Abdulla Meraris Soto Oscar Briz Dominik Bettinger Heike Bantel Sofia Del Carmen Maria A Serrano Andreas Geier Jose J G Marin Rocio I R Macias Source Type: research
Case Report: Case Series of Kocuria palustris Bacteremia among Immunocompromised Patients
We present three cases of bacteremia in immunocompromised patients admitted to our hospital; one patient was receiving chemotherapy for gall bladder carcinoma, the second was on maintenance hemodialysis for chronic kidney disease, and the third was receiving chemotherapy for acute myeloid leukemia. All three patients presented with a fever in the setting of neutropenia during the course of treatment with chemotherapy (in Cases 1 and 3) or hemodialysis (in Case 2). The blood culture samples of all the patients had pure isolates of Kocuria species K. palustris, which was identified by matrix assisted laser desorption ionisat...
Source: The American Journal of Tropical Medicine and Hygiene - September 18, 2023 Category: Tropical Medicine Authors: Gerlin Varghese Ashima Jamwal Deepika Sarawat Chinmoy Sahu Sangram Singh Patel Nidhi Tejan Source Type: research
Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma
CONCLUSION: In our study, the IMDC was confirmed to be a prognostic factor for MM. The IMDC groups were similar, except for the favorable RCC and MM groups. Different metastatic sites were prognostic, similar to the IMDC risk group in the MM group.PMID:37718781 | DOI:10.3233/CBM-230159
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Ismail Beyp ınar Y ıldız Sözel Arif Hakan Önder Source Type: research
Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Synchronous carcinoma of thymic carcinoma with lung adenocarcinoma: A rare case report
Asian J Surg. 2023 Sep 15:S1015-9584(23)01385-4. doi: 10.1016/j.asjsur.2023.08.222. Online ahead of print.NO ABSTRACTPMID:37718208 | DOI:10.1016/j.asjsur.2023.08.222
Source: Asian Journal of Surgery - September 17, 2023 Category: Surgery Authors: Xiangjin Liu Rongqian Wu Zhixian Tang Ling Li Source Type: research
MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway
Clin Immunol. 2023 Sep 15:109770. doi: 10.1016/j.clim.2023.109770. Online ahead of print.ABSTRACTThe combination of antiangiogenic agents and immune checkpoint inhibitors is more efficient than monotherapy in the management of hepatocellular carcinoma (HCC). Lenvatinib plus anti-PD1 antibodies have become the mainstay in HCC treatment. However, more than half the patients with HCC are non-responsive, and the mechanisms underlying drug resistance are unknown. To address this issue, we performed single-cell sequencing on samples from six HCC patients, aiming to explore cellular signals and molecular pathways related to the e...
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Cheng Zhou Bao-Ye Sun Pei-Yun Zhou Zhang-Fu Yang Zhu-Tao Wang Gao Liu Wei Gan Zheng Wang Jian Zhou Jia Fan Yong Yi Ning Ren Shuang-Jian Qiu Source Type: research
Gelatin-based 3D biomimetic scaffolds platform potentiates culture of cancer stem cells in esophageal squamous cell carcinoma
Biomaterials. 2023 Sep 11;302:122323. doi: 10.1016/j.biomaterials.2023.122323. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are crucial for tumorigenesis, metastasis, and therapy resistance in esophageal squamous cell carcinoma (ESCC). To further elucidate the mechanism underlying characteristics of CSCs and develop CSCs-targeted therapy, an efficient culture system that could expand and maintain CSCs is needed. CSCs reside in a complex tumor microenvironment, and three-dimensional (3D) culture systems of biomimetic scaffolds are expected to better support the growth of CSCs by recapitulating the biophysical prop...
Source: Biomaterials - September 17, 2023 Category: Materials Science Authors: Yenan Wu Haiwei Liang Aiping Luo Yong Li Zhiqiang Liu Xin Li Wenxin Li Kaini Liang Junyang Li Zhihua Liu Yanan Du Source Type: research
Improved clinical outcomes in advanced hepatocellular carcinoma treated with transarterial chemoembolization plus atezolizumab and bevacizumab: a bicentric retrospective study
CONCLUSIONS: Compared with Atez/Bev treatment, TACE-Atez/Bev showed better OS, PFS, and ORR for Chinese patients with advanced HCC, with an acceptable safety profile.PMID:37718456 | DOI:10.1186/s12885-023-11389-x
Source: Cancer Control - September 17, 2023 Category: Cancer & Oncology Authors: Fei Cao Changsheng Shi Guofu Zhang Jun Luo Jiaping Zheng Weiyuan Hao Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Comprehensive analysis of subtypes and risk model based on complement system associated genes in ccRCC
CONCLUSIONS: Two distinct CS patterns were identified and were further analyzed in terms of infiltration of TME immune cells and immune escape, providing potential explanations for the impact on prognosis of ccRCC. Our CSscore prognostic model may offer a novel perspective in the management of ccRCC patients, and potentially other types of cancer as well.PMID:37717714 | DOI:10.1016/j.cellsig.2023.110888
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Yang Li Muzhapaer Maimaiti Bowen Yang Zeyi Lu Qiming Zheng Yudong Lin Wenqin Luo Ruyue Wang Lifeng Ding Huan Wang Xianjiong Chen Zhehao Xu Mingchao Wang Gonghui Li Lei Gao Source Type: research
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
In this study, we focused on the effect of the C-terminal domain of Hsp90 on VDAC1 oligomerization, ubiquitination, and VDAC1 channel activity. We found that Hsp90 C-terminal domain inhibitor Novobiocin promoted VDAC1 oligomerization, release of cytochrome c, and activated mitochondrial apoptosis pathway. Atomic coarse particle modeling simulation revealed C-terminal domain of Hsp90α stabilized VDAC1 monomers. The purified VDAC1 was reconstituted into a planar lipid bilayer, and electrophysiology experiments of patch clamp showed that the Hsp90 C-terminal inhibitor Novobiocin increased VDAC1 channel conductance via promot...
Source: Neoplasia - September 17, 2023 Category: Cancer & Oncology Authors: Jinxin Zhang Lixia Liu Yan Li Yaling Huang Senbo Xiao Zihao Deng Zhenming Zheng Jieyou Li Manfeng Liang Guantai Xie Xiao Chen Yaotang Deng Wenchong Tan Hairou Su Guibing Wu Chunqing Cai Xuemei Chen Fei Zou Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
