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Cancer: Carcinoma
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Intracavitary cardiac metastasis of cervical squamous cell carcinoma with immune thrombocytopenia: a rare case report
We present the case of an adult patient diagnosed with cervical cancer and concurrent right ventricular cancer thrombus, accompanied by immune thrombocytopenia (ITP). The patient exhibited resistance to conventional ITP drugs, with suboptimal platelet response. However, upon achieving initial control of the tumor, the patient's platelet counts returned to normal. Notably, the addition of immune checkpoint inhibitors targeting PD-L1 resulted in effective tumor control, accompanied by sustained high platelet levels. Unfortunately, during subsequent anti-tumor therapy, the patient experienced a prolonged platelet rise time, r...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ning Liu Deguan Lv Raydonna Rachel Schneider Hongyan Yang Mingyan Zhang Yanan Liu Meili Sun Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
A Golgi-Targeted Platinum Complex Plays a Dual Role in Autophagy Regulation for Highly Efficient Cancer Therapy
Angew Chem Int Ed Engl. 2023 Sep 14:e202312170. doi: 10.1002/anie.202312170. Online ahead of print.ABSTRACTRegulating autophagy to control the homeostatic recycling process of cancer cells is a promising anticancer strategy. Golgi apparatus is a substrate of autophagy but Golgi-autophagy (Golgiphagy) mediated antitumor pathway is rarely reported. Herein, we have developed a novel Golgi-targeted platinum (II) complex Pt3, which is ca. 20 times more cytotoxic to lung carcinoma than cisplatin and can completely eliminate tumors after intratumoral administration in vivo. Its nano-encapsulated system for tail vein administratio...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Bing-Bing Liang Qian Liu Bin Liu Hua-Gang Yao Juan He Cheng-Fei Tang Kun Peng Xu-Xian Su Yue Zheng Jia-Yi Ding Jianliang Shen Qian Cao Zong-Wan Mao Source Type: research
A Case of Metastatic Papillary Thyroid Carcinoma in Neck Lymph Nodes Without Primary Tumor in Thyroid Gland
We report the case of a 63-year-old male who had a left neck level II palpable mass. A left cervical mass had previously undergone 2 central needle biopsies, but only atypical cells had been identified. His prior medical history included surgical treatment for prostate cancer 11 years ago. There was no suspicious primary tumor in the endoscopic examination. After the excisional biopsy, the pathologic finding was metastatic papillary carcinoma from the thyroid, and there were no aberrant findings in the thyroid sonography. The patient underwent a complete thyroidectomy, bilateral central neck dissection (CND), and left leve...
Source: Ear, Nose and Throat Journal - September 15, 2023 Category: ENT & OMF Authors: Sung Ha Jung Joo Hyun Park Junyoung Kim Nayeon Choi Source Type: research
TMEM64 is highly expressed in hepatocellular carcinoma and promotes tumor cell proliferation and invasion
CONCLUSION: A high TMEM64 expression may serve as an independent risk factor for poor prognosis of HCC and promotes proliferation, migration, and invasion of HCC cells in vitro.PMID:37712271 | DOI:10.12122/j.issn.1673-4254.2023.08.11
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: D Cao J Cai Y Li R Dong Z Wang X Zuo Source Type: research
Dealcoholized red wine inhibits occurrence and progression of hepatocellular carcinoma possibly by inducing cell cycle arrest and apoptosis
CONCLUSION: DRW inhibits the occurrence and progression of HCC, and this effect is mediated possibly by inducing cell cycle arrest and apoptosis.PMID:37712265 | DOI:10.12122/j.issn.1673-4254.2023.08.05
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Y Lan K Wang Z Lan H Zhou J Sun Source Type: research
Germline founder variant c.1998delinsTTCT in the RET oncogene: a cohort study in 15 Belgian families
CONCLUSION: The c.1998delinsTTCT- variant in the RET gene is pathogenic and associated with a moderate risk for medullary thyroid carcinoma and rarely with other MEN2A manifestations. Active surveillance is a possible option in heterozygous gene carriers with a negative first clinical evaluation.PMID:37713609 | DOI:10.1093/ejendo/lvad126
Source: European Journal of Endocrinology - September 15, 2023 Category: Endocrinology Authors: Axelle Vuylsteke Laurens Hannes Hilde Brems Koen Devis Marleen Renard Anne Uyttebroeck Eric Legius Brigitte Decallonne Source Type: research
Isthmusectomy for papillarythyroid carcinoma in the isthmus: The less the better
CONCLUSIONS: Our results reveal that isthmusectomy plus BCLND may be a simple but feasible approach for selected PTCI patients, resulting in a better quality of life than total thyroidectomy plus BCLND.PMID:37714784 | DOI:10.1016/j.asjsur.2023.08.197
Source: Asian Journal of Surgery - September 15, 2023 Category: Surgery Authors: Jiaqiang Dan Jingya Tan Yao Guo Yang Xu Jin Chen Junhua Huang Source Type: research
Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction
Chemistry. 2023 Sep 15:e202302465. doi: 10.1002/chem.202302465. Online ahead of print.ABSTRACTA literature survey showed that different derivatives with the 9-phenyl-9H-carbazole or the dihydroindoline scaffold may be of biological activity including cytotoxic effect. Driven by this experience, we wished to synthesize P-functionalized derivatives of the above mentioned N-heterocycles. Three N-heterocycles, 9-(4-bromophenyl)-9H-carbazole, 3-bromo-9-phenyl-9H-carbazole and 1-(5-bromoindolin-1-yl)ethan-1-one were coupled with dialkyl phosphites and diarylphosphine oxides using Pd(OAc)2 (10%) as the catalyst precursor and trie...
Source: Chemistry - September 15, 2023 Category: Chemistry Authors: Bianka Husz ár Ren áta Szolga Szilvia B ősze Rita Ol áhné Szabó Andr ás Simon Konstantin Karaghiosoff M átyás Czugler L ászló Drahos Gy örgy Keglevich Source Type: research
A Golgi-Targeted Platinum Complex Plays a Dual Role in Autophagy Regulation for Highly Efficient Cancer Therapy
Angew Chem Int Ed Engl. 2023 Sep 14:e202312170. doi: 10.1002/anie.202312170. Online ahead of print.ABSTRACTRegulating autophagy to control the homeostatic recycling process of cancer cells is a promising anticancer strategy. Golgi apparatus is a substrate of autophagy but Golgi-autophagy (Golgiphagy) mediated antitumor pathway is rarely reported. Herein, we have developed a novel Golgi-targeted platinum (II) complex Pt3, which is ca. 20 times more cytotoxic to lung carcinoma than cisplatin and can completely eliminate tumors after intratumoral administration in vivo. Its nano-encapsulated system for tail vein administratio...
Source: Angewandte Chemie - September 15, 2023 Category: Chemistry Authors: Bing-Bing Liang Qian Liu Bin Liu Hua-Gang Yao Juan He Cheng-Fei Tang Kun Peng Xu-Xian Su Yue Zheng Jia-Yi Ding Jianliang Shen Qian Cao Zong-Wan Mao Source Type: research
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Arch Toxicol. 2023 Sep 15. doi: 10.1007/s00204-023-03600-6. Online ahead of print.ABSTRACTOccupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with a very low survival rate after metastasis. Increased activity of plasmin is a hallmark in NSCLC metastasis. It is accepted that metastatic cells exhibit higher plasmin activity than cells from primary tumors. Mechanisms behind this elevation, however, are barely understood. We compared plasmin activity and cell migration of A549 cells derived from a primary lung tumor with metastatic H12...
Source: Archives of Toxicology - September 15, 2023 Category: Toxicology Authors: Sarah Zeitlmayr Ditila Cami Belinda Selmani Thomas Gudermann Andreas Breit Source Type: research
Resection of Papillary Thyroid Carcinoma Involving a Functioning Recurrent Laryngeal Nerve: Pushing Boundaries to Preserve Nerve Function
Ann Surg Oncol. 2023 Sep 15. doi: 10.1245/s10434-023-14287-5. Online ahead of print.NO ABSTRACTPMID:37713120 | DOI:10.1245/s10434-023-14287-5
Source: Ann Oncol - September 15, 2023 Category: Cancer & Oncology Authors: Anthony T Saxton Randall P Scheri Source Type: research
Clinical experiences with online adaptive radiotherapy of vulvar carcinoma
CONCLUSION: CTVs and PTVs dose coverage were significantly improved with adaptation compared to image-guided RT. This gain was robust during the treatment time.PMID:37713179 | DOI:10.1080/0284186X.2023.2257377
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Malene E Bak Nikolaj K G Jensen Trine J N øttrup Hanne F Mathiesen Henrik Roed Maria Sj ölin Flemming Kj ær-Kristoffersen Vibeke N Hansen Ivan R Vogelius Source Type: research
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Sci Immunol. 2023 Sep 15;8(87):eadf6717. doi: 10.1126/sciimmunol.adf6717. Epub 2023 Sep 15.ABSTRACTHuman regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Feng Shan Anthony R Cillo Carly Cardello Daniel Y Yuan Sheryl R Kunning Jian Cui Caleb Lampenfeld Asia M Williams Alexandra P McDonough Arjun Pennathur James D Luketich John M Kirkwood Robert L Ferris Tullia C Bruno Creg J Workman Panayiotis V Benos Dario Source Type: research
Qualitative analysis of the coding of pathological data of cancer registry centers: A study in North of Iran
CONCLUSION: The most reports were on carcinoma morphology, and the Kappa coefficient in morphology codes has almost complete reliability. In terms of behavior coding, there was the most agreement in the category of benign cancers. The Kappa coefficient in given behavior codes has low reliability.PMID:37713374 | DOI:10.1371/journal.pone.0291139
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Mohammad-Ali Jahani Ghahraman Mahmoudi Hossein-Ali Nikbakht Zeinab Farhadi Raziehsadat Mousavi Source Type: research
