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Cancer: Carcinoma
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Total 98998 results found since Jan 2013.
TACE Combined with Lenvatinib and Camrelizumab for Unresectable Multiple Nodular and Large Hepatocellular Carcinoma ( & gt;5 cm)
CONCLUSIONS: In patients with unresectable multiple nodular and large HCC (single nodular diameter of >5 cm), TACE combined with target therapy and immunotherapy is safe and effective.PMID:37723998 | DOI:10.1177/15330338231200320
Source: Technology in Cancer Research and Treatment - September 19, 2023 Category: Cancer & Oncology Authors: Zhanwang Xiang Guohong Li Luwen Mu Haofan Wang Churen Zhou Huzheng Yan Mingsheng Huang Source Type: research
ASO Visual Abstract: Shaving Papillary Thyroid Carcinoma Involving Functioning Recurrent Laryngeal Nerve-Safety of Incomplete Tumor Resection and Nerve Sparing
Ann Surg Oncol. 2023 Sep 19. doi: 10.1245/s10434-023-14228-2. Online ahead of print.NO ABSTRACTPMID:37725225 | DOI:10.1245/s10434-023-14228-2
Source: Ann Oncol - September 19, 2023 Category: Cancer & Oncology Authors: Hyoung Shin Lee Yeongjoon Kim Seo Bin Kim Dong Gyu Choi Hyun Kyoung Cha Ji Su Park Sungmin Jun Kang Dae Lee Source Type: research
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Cell Res. 2023 Sep 19. doi: 10.1038/s41422-023-00874-4. Online ahead of print.ABSTRACTGlycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here, we find that low levels of glycolytic metabolite 3-phosphoglycerate (3-PGA) can switch phosphoglycerate dehydrogenase (PHGDH) from cataplerosis serine synthesis to pro-apoptotic activation of p53. PHGDH is a p53-binding protein, and when unoccupied by 3-PGA interacts with the scaffold pro...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zhen Source Type: research
Impact of adjuvant chemotherapy on long-term overall survival in patients with high-risk stage II colon cancer: a nationwide cohort study
CONCLUSION: 5-year overall survival was significantly higher in patients with high-risk stage II colon cancer treated with adjuvant chemotherapy compared with no chemotherapy. Adjuvant treatment was given to less than half of the patients who were eligible for it.PMID:37725517 | DOI:10.1080/0284186X.2023.2251086
Source: Acta Oncologica - September 19, 2023 Category: Cancer & Oncology Authors: Victoria Rosberg Mikkel Jessen Camilla Qvortrup Henry George Smith Peter-Martin Krarup Source Type: research
Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells
CONCLUSIONS: These data suggest that TBCK could potentially have a crucial function in influencing the effects of anti-cancer drugs including TRAIL by modulating the signaling pathway involving Akt and PDK1 in human renal cancer cells.PMID:37725269 | DOI:10.1007/s13258-023-01453-y
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Cho-Young Park Ji-Hoon Jang In-Hwan Song Joo-Young Kim Kyung-Oh Doh Tae-Jin Lee Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
Comparative Analysis of First-Line FOLFOX Treatment With and Without Anti-VEGF Therapy in Metastatic Colorectal Carcinoma: A Real-World Data Study
CONCLUSION: Our real-world data analysis suggests that the addition of anti-VEGF to FOLFOX offers limited and short-lived benefits in the context of mCRC and may provide differential survival benefit based on tumor sidedness.PMID:37724508 | DOI:10.1177/10732748231202470
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ronen Brenner Shlomit Amar-Farkash Avital Klein-Brill Keren Rosenberg-Katz Dvir Aran Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
Efficacy of TACE Combined with Lenvatinib Plus Sintilimab for Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava and/or Right Atrium
CONCLUSION: TACE combination with lenvatinib plus sintilimab is effective in treating HCC with IVC and/or RA TT. The toxicities were manageable, with no unexpected safety signals. The baseline levels of serum PCT might be the predictive biomarkers for the triple combination therapy.PMID:37724186 | PMC:PMC10505388 | DOI:10.2147/JHC.S410967
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Shangkun Ning Xinge Li Xiangyu Ma Jibing Liu Xu Chang Source Type: research
TACE Combined with Lenvatinib and Camrelizumab for Unresectable Multiple Nodular and Large Hepatocellular Carcinoma ( & gt;5 cm)
CONCLUSIONS: In patients with unresectable multiple nodular and large HCC (single nodular diameter of >5 cm), TACE combined with target therapy and immunotherapy is safe and effective.PMID:37723998 | DOI:10.1177/15330338231200320
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Zhanwang Xiang Guohong Li Luwen Mu Haofan Wang Churen Zhou Huzheng Yan Mingsheng Huang Source Type: research
Gene of the month: GATA3
J Clin Pathol. 2023 Sep 19:jcp-2023-209017. doi: 10.1136/jcp-2023-209017. Online ahead of print.ABSTRACTGATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic resp...
Source: Clinical Genitourinary Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Zekai Qiang Ibrahim Jubber Kirsty Lloyd Marcus Cumberbatch Jon Griffin Source Type: research
Secondary Breast Angiosarcoma After a Primary Diagnosis of Breast Cancer: A Retrospective Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database
CONCLUSIONS: We demonstrate an increasing incidence of SBA over the study period. These data can help inform shared decision-making for optimal management of locoregional breast cancer and raise awareness of secondary angiosarcoma.PMID:37725702 | DOI:10.1097/COC.0000000000001045
Source: Clinical Genitourinary Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Bonny Chau Elizabeth T Loggers Lee D Cranmer Harveshp Mogal Jeremy M Sharib Edward Y Kim Stephanie K Schaub Kelly G Paulson Hannah M Linden Jennifer M Specht Janice N Kim Sara H Javid Michael J Wagner Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
RT-qPCR Analysis of LAMP3 (CD208) Gene Expression in Oral Lichen Planus and Oral Squamous Cell Carcinoma
CONCLUSIONS: According to the findings of this study, it can be concluded that the expression of the LAMP3 gene in SCC lesions is higher than in healthy tissue. Hence, LAMP3 gene expression can be used as a diagnostic biomarker.PMID:37724152 | PMC:PMC10505466 | DOI:10.52547/rbmb.12.1.36
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Farnaz Mohajertehran Nooshin Mohtasham Mojtaba Ahmadi Mehdi Shahabinejad Maryam Mohammadi Source Type: research
The Prognostic Significance of P16 Immunohistochemical Expression Pattern in Women with Invasive Ductal Breast Carcinoma
CONCLUSIONS: Our study demonstrated that p16 protein expression increased in ER-positive tumor tissue from patients with invasive ductal breast carcinoma. However, no correlation was found between the p16 protein expression and the other clinicopathological features.PMID:37724141 | PMC:PMC10505467 | DOI:10.52547/rbmb.12.1.83
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Alireza Rezaei Navidreza Shayan Saman Shirazinia Sara Mollazadeh Negin Ghiyasi-Moghaddam Source Type: research
