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Total 25370 results found since Jan 2013.
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice
In conclusion, our study demonstrated that in an elderly mouse population, DOX induces cardiac inflammation, autophagy, and apoptosis in the heart in the short term. When kept for a longer period, oxidative-stress-linked pathways remained altered, as well as autophagy markers and tissue damage after DOX treatment, emphasizing the need for continuous post-treatment cardiac monitoring.PMID:37676301 | DOI:10.1007/s00204-023-03586-1
Source: Archives of Toxicology - September 7, 2023 Category: Toxicology Authors: Ana Reis-Mendes Mariana Ferreira Jos é Alberto Duarte Margarida Duarte-Ara újo Fernando Remi ão F élix Carvalho Em ília Sousa Maria Lourdes Bastos Vera Marisa Costa Source Type: research
Radiation-Induced Carotid Artery Stenosis: What Nurses Need to Know
This article provides an overview of the incidence, risk factors, detection, surveillance, and management of RI-CAS in cancer survivors.METHODS: A literature search was conducted using PubMed®, Embase®, and Web of Science for articles published from January 2008 through June 2022. Search terms included carotid stenosis, radiation therapy, and cancer survivors. This updated review includes content from older references, which serve as a literature-based foundation for the clinical care of cancer survivors at risk for or diagnosed with RI-CAS.FINDINGS: CAS is a long-term sequela of RT to the neck and can lead to serious co...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Ellen Mullen Source Type: research
Prognostic value of minimal disseminated disease assessed using digital PCR for 3' < em > ALK < /em > assays in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.282812. Online ahead of print.ABSTRACTNot available.PMID:37675509 | DOI:10.3324/haematol.2023.282812
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Reiji Fukano Yuka Iijima-Yamashita Hideto Iwafuchi Atsuko Nakazawa Akiko M Saito Tetsuya Takimoto Masahiro Sekimizu Yutaka Suehiro Takahiro Yamasaki Shunji Hasegawa Tetsuya Mori Keizo Horibe Source Type: research
Radiation-Induced Carotid Artery Stenosis: What Nurses Need to Know
This article provides an overview of the incidence, risk factors, detection, surveillance, and management of RI-CAS in cancer survivors.METHODS: A literature search was conducted using PubMed®, Embase®, and Web of Science for articles published from January 2008 through June 2022. Search terms included carotid stenosis, radiation therapy, and cancer survivors. This updated review includes content from older references, which serve as a literature-based foundation for the clinical care of cancer survivors at risk for or diagnosed with RI-CAS.FINDINGS: CAS is a long-term sequela of RT to the neck and can lead to serious co...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Ellen Mullen Source Type: research
Prognostic value of minimal disseminated disease assessed using digital PCR for 3' < em > ALK < /em > assays in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.282812. Online ahead of print.ABSTRACTNot available.PMID:37675509 | DOI:10.3324/haematol.2023.282812
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Reiji Fukano Yuka Iijima-Yamashita Hideto Iwafuchi Atsuko Nakazawa Akiko M Saito Tetsuya Takimoto Masahiro Sekimizu Yutaka Suehiro Takahiro Yamasaki Shunji Hasegawa Tetsuya Mori Keizo Horibe Source Type: research
Radiation-Induced Carotid Artery Stenosis: What Nurses Need to Know
This article provides an overview of the incidence, risk factors, detection, surveillance, and management of RI-CAS in cancer survivors.METHODS: A literature search was conducted using PubMed®, Embase®, and Web of Science for articles published from January 2008 through June 2022. Search terms included carotid stenosis, radiation therapy, and cancer survivors. This updated review includes content from older references, which serve as a literature-based foundation for the clinical care of cancer survivors at risk for or diagnosed with RI-CAS.FINDINGS: CAS is a long-term sequela of RT to the neck and can lead to serious co...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Ellen Mullen Source Type: research
A case of Hodgkin lymphoma-type Richter syndrome presenting as small-intestinal perforation
Int J Hematol. 2023 Sep 6. doi: 10.1007/s12185-023-03655-2. Online ahead of print.ABSTRACTHodgkin lymphoma type of Richter syndrome (HL-type RS) is a rare disease that arises in patients with chronic lymphocytic leukemia (CLL). HL-type RS lesions can manifest in various sites and are often accompanied by related symptoms. This is the first case report to describe diagnosis of HL-type RS after emergency surgery for gastrointestinal perforation caused by the development of a HL-type RS lesion. A 47-year-old man diagnosed with CLL three years prior began treatment with ibrutinib due to worsening anemia and splenomegaly two mo...
Source: International Journal of Hematology - September 6, 2023 Category: Hematology Authors: Kosuke Miki Reiki Ogasawara Shunsuke Sugimura Junichi Sugita Rintaro Nozu Keisuke Kojima Daisuke Hidaka Ai Shimizu Kohei Okada Naoki Kobayashi Masahiro Ogasawara Masahiro Imamura Yoshihiro Matsuno Shuichi Ota Source Type: research
Oncogenic viral DNA related to human breast cancer found on cattle milk and meat
Comp Immunol Microbiol Infect Dis. 2023 Aug 27;101:102053. doi: 10.1016/j.cimid.2023.102053. Online ahead of print.ABSTRACTBovine leukemia virus (BLV) is a major cause of lymphoma in cattle and has been recently correlated to breast cancer in humans. How and whether BLV might reach humans remains unknown but it could be through cattle-derived milk and meat. Here our aim was to investigate whether BLV DNA could be found in fresh milk and raw meat destined to human consumption and whether anti-BLV antibodies could be detected in human blood at the same geographical region. Milk (n = 36) and meat (n = 54) samples were collect...
Source: Comparative immunology, microbiology and infectious diseases. - September 6, 2023 Category: Allergy & Immunology Authors: Daniel Lazzari de Quadros Vitoria Agnoletto Ribeiro Mariana Antunes Rezende Yasmin Ampese Mat é M árcio Alexandro Gomes Katia Secchi Daisy Maria Strottmann Rafael Frandoloso Luiz Carlos Kreutz Source Type: research
The shifting therapeutic paradigm for relapsed/refractory mantle cell lymphoma
Leuk Res. 2023 Sep 1;134:107385. doi: 10.1016/j.leukres.2023.107385. Online ahead of print.ABSTRACTMantle cell lymphoma (MCL) is a heterogeneous subtype of non-Hodgkin lymphoma that has been historically associated with poor 5-year overall survival rates, especially for aggressive variants. Traditional cytotoxic chemotherapy had been a mainstay of therapy for relapsed/refractory (R/R) MCL for many years until the advent of molecularly targeted therapies and cell-based approaches. However, a significant concern is the lack of definitive consensus guidelines for management of R/R MCL. The managerial conundrum partly stems fr...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Sumukh Arun Kumar Jenny Gao Shyam A Patel Source Type: research
Phase 1 Dose Escalation and Expansion Study of Golidocitinib, a Highly Selective JAK1 Inhibitor, in Relapsed or Refractory Peripheral T Cell Lymphomas
CONCLUSIONS: In this phase 1 study, golidocitinib demonstrated an acceptable safety profile and encouraging antitumor efficacy in heavily pre-treated patients with r/r PTCLs. These results support the initiation of the multinational pivotal study in patients with r/r PTCLs.PMID:37673210 | DOI:10.1016/j.annonc.2023.08.013
Source: Ann Oncol - September 6, 2023 Category: Cancer & Oncology Authors: Y Song D H Yoon H Yang J Cao D Ji Y Koh H Jing H Eom J Kwak W Lee J Lee H Shin J Jin M Wang Z Yang W Kim J Zhu Source Type: research
