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Cancer: Lung Cancer
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With Comparable Outcomes, Should Early Stage Lung Cancer Be A Contraindication to Lung Transplant?
CONCLUSIONS: One- and 5-year survival rates were comparable between LTx recipients with incidentally noted pathological Stage I NSCLC and contemporary recipients without cancer. All cancer-related mortality occurred in recipients with incidentally noted advanced NSCLC. These results suggest that patients with pathological Stage I lung cancer at the time of transplant have outcomes comparable to those without cancer findings at the time of transplant.PMID:37704001 | DOI:10.1016/j.athoracsur.2023.09.002
Source: The Annals of Thoracic Surgery - September 13, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Connor S Spies Timothy N Ochoa Arya Pontula Chelsea S Harris Laurie D Snyder Elizabeth N Pavlisko Matthew G Hartwig Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Molecular docking analysis of mefluhybenamine with lung cancer targets
Bioinformation. 2022 Dec 31;18(12):1186-1191. doi: 10.6026/973206300181186. eCollection 2022.ABSTRACTLung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. There...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Youssef S Alghamdi Source Type: research
Ugonin P inhibits lung cancer motility by suppressing DPP-4 expression via promoting the synthesis of miR-130b-5p
This study provides compelling evidence that ugonin P could be used to develop novel therapeutic agents for the treatment of lung cancer.PMID:37703658 | DOI:10.1016/j.biopha.2023.115483
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Chih-Ying Wu Shubham Suresh Ghule Chih-Chuang Liaw David Achudhan Shuen-Yih Fang Po-I Liu Chang-Lun Huang Ching-Liang Hsieh Chih-Hsin Tang Source Type: research
Molecular docking analysis of mefluhybenamine with lung cancer targets
Bioinformation. 2022 Dec 31;18(12):1186-1191. doi: 10.6026/973206300181186. eCollection 2022.ABSTRACTLung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. There...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Youssef S Alghamdi Source Type: research
Fenretinide induces apoptosis and synergises the apoptosis inducing effect of gemcitabine through inhibition of key signalling molecules involved in A549 cell survival in in silico and in vitro analyses
In conclusion, Akt may be exploited as a good target for induction of apoptosis in A549 cells and fenretinide has great potentials to fulfil this task. The mechanism by which fenretinide boosts the apoptosis inducing effects of gemcitabine, which is likely expected to be via inhibiting mTORC2 downstream targets. However, docking investigation revealed that fenretinide lacks specificity as it may also interact with several secondary targets beside Akt.PMID:37704095 | DOI:10.1016/j.cellsig.2023.110885
Source: Cellular Signalling - September 13, 2023 Category: Cytology Authors: Hazem A Al-Bustany Hawzheen A Muhammad Mahmoud A Chawsheen Phil R Dash Source Type: research
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00212.1. Online ahead of print.ABSTRACTNicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at the back of the chest. X-ray radiation was delivered to the thoracic area and different doses of nicaraven (0, 20, 50, 100 mg/kg) were administr...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: Lina Abdelghany Yong Xu Reiko Sekiya Chen Yan Keiichi Jingu Tao-Sheng Li Source Type: research
Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research
Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17936. Online ahead of print.ABSTRACTThe most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms inclu...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Arghavan Memarzia Saeideh Saadat Fereshteh Asgharzadeh Sepide Behrouz Gert Folkerts Mohammad Hossein Boskabady Source Type: research
Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: J Cell Mol Med - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research
Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17936. Online ahead of print.ABSTRACTThe most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms inclu...
Source: J Cell Mol Med - September 12, 2023 Category: Molecular Biology Authors: Arghavan Memarzia Saeideh Saadat Fereshteh Asgharzadeh Sepide Behrouz Gert Folkerts Mohammad Hossein Boskabady Source Type: research
