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Schweinfurthiamide, a new alkaloid isolated from the tuber roots of < em > Asparagus flagellaris < /em > Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Natural Product Research - September 18, 2023 Category: Biochemistry Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research
Overall signature of acquired KRAS gene changes in advanced non-small cell lung cancer patient with EGFR-TKI resistance
CONCLUSIONS: This study provides significant evidence of the role of acquired KRAS variants in the development of resistance to epidermal growth factor receptor-tyrosine kinase inhibitor therapy. Our results contribute to the growing body of knowledge on the mutational profiles associated with resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment. Furthermore, our study highlights the KRAS gene change as a significant mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitor therapy.PMID:37721193 | DOI:10.1093/jjco/hyad123
Source: Clinical Lung Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Jie Zheng Yuanyao Dou Daijuan Huang Yubo Wang Rui Han Chen Hu Mengxiao Zhu Conghua Lu Caiyu Lin Di Wu Yihui Liu Huan Tang Tingting He Weilin Jiang Yong He Source Type: research
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer-Opportunities for Drug Repurposing
Appl Biochem Biotechnol. 2023 Sep 18. doi: 10.1007/s12010-023-04595-7. Online ahead of print.ABSTRACTGlobally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma. One of the most vital aspects for proper diagnosis, prognosis, and adequate therapy is the precise classification of non-small cell lung cancer based on biomarke...
Source: Applied Biochemistry and Biotechnology - September 18, 2023 Category: Biochemistry Authors: Rajdeep Kaur P K Suresh Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Journal of Applied Clinical Medical Physics - September 18, 2023 Category: Physics Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | DOI:10.1080/15384047.2023.2256906
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Discovery of YS-363 as a highly potent, selective, and orally e fficacious EGFR inhibitor
This study reports on a novel quinazoline-based compound called YS-363 that acts as a new EGFR inhibitor. YS-363 demonstrated potent inhibition against both wild-type and L858R mutant forms of EGFR with IC50 values of 0.96 nM and 0.67 nM, respectively. Additionally, YS-363 had a reversible inhibitory effect on cellular EGFR signaling, had excellent inhibitory activity on cell proliferation and migration, and induced G0/G1 cell cycle arrest and apoptosis. In xenograft models dependent on EGFR signaling, oral administration of YS-363 substantially suppressed tumor growth by inhibiting this pathway. In summary, YS-363 is a pr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Pengxing He Jing Jing Linna Du Xuyang Zhang Yufei Ren Han Yang Bin Yu Hongmin Liu Source Type: research
Schweinfurthiamide, a new alkaloid isolated from the tuber roots of < em > Asparagus flagellaris < /em > Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Natural Product Research - September 18, 2023 Category: Biochemistry Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research
Silencing lncRNA EZR ‑AS1 induces apoptosis and attenuates the malignant properties of lung adenocarcinoma cells
This study aimed to investigate the effect of silencing long non-coding RNA (lncRNA) EZR‑AS1 on the biological behaviors of lung adenocarcinoma (ADC) cells. EZR‑AS1 expression levels in lung ADC tissues and cells, as well as in adjacent non-cancerous tissues, were determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). EZR‑AS1 was knocked down in two lung ADC cell lines using small interfering RNA specific for EZR‑AS1 (siEZR‑AS1). Proliferation, migration, and apoptosis of EZR‑AS1-knockdown cells were assessed using the CCK-8 viability assay, flow cytometry, or wound healing exp...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Xianjing Yu Lixue Wu Zhongcui Lu Junli Zhang Yunfeng Zhou Source Type: research
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer-Opportunities for Drug Repurposing
Appl Biochem Biotechnol. 2023 Sep 18. doi: 10.1007/s12010-023-04595-7. Online ahead of print.ABSTRACTGlobally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma. One of the most vital aspects for proper diagnosis, prognosis, and adequate therapy is the precise classification of non-small cell lung cancer based on biomarke...
Source: Applied Biochemistry and Biotechnology - September 18, 2023 Category: Biochemistry Authors: Rajdeep Kaur P K Suresh Source Type: research
Awareness on passive smoking among Indian adults
Bioinformation. 2023 Jan 31;19(1):10-13. doi: 10.6026/97320630019010. eCollection 2023.ABSTRACTAround one-third of adults worldwide regularly come into contact with passive smoking. In addition to many other health issues, non-smokers who are exposed to passive smoking at home or at work have a 20-30% higher risk of acquiring lung cancer. The current study set out to determine adult smokers' awareness of the hazards of passive smoking as well as the efficacy of an education campaign in raising that awareness. To finish the investigation, a pre-experimental research approach was employed. 60 adults between the ages of 18 an...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Sivasubramanian N Mahalakshmi B Patel Shivani Arvindbhai Ramalakshmi G Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Health Physics - September 18, 2023 Category: Physics Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis
CONCLUSIONS: LINC00668 acted as an oncogene in NSCLC progression through miR-518c-3p/TRIP4 axis. Our study disclosed a new mechanism of LINC00668 functioned in NSCLC and may give a deeper insight of the targeted therapy of NSCLC in the future.PMID:37718780 | DOI:10.3233/CBM-230154
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Zhibin Lu Zhichao Xiao Qi Wang Chunfeng Pan Yang Xia Weibing Wu Liang Chen Source Type: research
Machine learning developed a programmed cell death signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma
CONCLUSION: Our study developed a novel CDS for LUAD. The CDS served as an indicator for predicting the prognosis and immunotherapy benefits of LAUD patients.PMID:37722290 | DOI:10.1016/j.tranon.2023.101784
Source: Translational Oncology - September 18, 2023 Category: Cancer & Oncology Authors: Dongxiao Ding Liangbin Wang Yunqiang Zhang Ke Shi Yaxing Shen Source Type: research
Dosimetric impact of MLC positional errors on dose distribution in IMRT
This study investigates dose sensitivity variations and complexity metrics of MLC positional error in volumetric modulated arc therapy and determines the acceptable ranges of MLC positional accuracy in several clinical situations. Treatment plans were generated for four treatment sites (prostate cancer, lung cancer, spinal, and brain metastases) using different treatment planning systems (TPSs) and fraction sizes. Each treatment plan introduced 0.25-2.0 mm systematic or random MLC leaf bank errors. The generalized equivalent uniform dose (gEUD) sensitivity and complexity metrics (MU/Gy and plan irregularity) were calculate...
Source: Journal of Applied Clinical Medical Physics - September 18, 2023 Category: Physics Authors: Hiromi Enomoto Yukio Fujita Saki Matsumoto Yujiro Nakajima Miyuki Nagai Ayako Tonari Takeshi Ebara Source Type: research
Awareness on passive smoking among Indian adults
Bioinformation. 2023 Jan 31;19(1):10-13. doi: 10.6026/97320630019010. eCollection 2023.ABSTRACTAround one-third of adults worldwide regularly come into contact with passive smoking. In addition to many other health issues, non-smokers who are exposed to passive smoking at home or at work have a 20-30% higher risk of acquiring lung cancer. The current study set out to determine adult smokers' awareness of the hazards of passive smoking as well as the efficacy of an education campaign in raising that awareness. To finish the investigation, a pre-experimental research approach was employed. 60 adults between the ages of 18 an...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Sivasubramanian N Mahalakshmi B Patel Shivani Arvindbhai Ramalakshmi G Source Type: research
